This application seeks renewed support for the Genetics Graduate Training Program at Case Western Reserve University (Case). The goal of the Genetics Training program at Case is to train pre-doctoral students in the use of genetics for investigations into important biological and biomedical problems. The defining element of the program is its breadth, as a wide range of organisms, biological systems, and approaches are being used in training laboratories, located in several departments including Genetics, Biology, Molecular Biology, Neuroscience, Pediatrics, Medicine and Anesthesiology. This integrated training program reflects the commitment of the training faculty to the diversity of eukaryotic genetics as a unifying theme. Training is achieved through five primary mechanisms: (i) rigorous and well developed graduate courses, (ii) a weekly journal club, (iii) a seminar program featuring outside speakers, (iv) a seminar program featuring student research presentations, and (v) independent research in laboratories with active, well-funded programs. Other activities such as an annual student-run Genetics Colloquium, lab meetings, Clinical Genetics Grand Rounds and special interest group meetings add to the training environment. As documented in this application the program has experienced significant success. The training program offers its trainees a broad based genetics curriculum taught by both clinical and basic science faculty and offers its students research opportunities in Developmental Genetics, Genetic Models of Human Disease and Bioinformatics/Computational Genomics. Students, irrespective of their choice of thesis projects, are exposed to a multitude of genetic methodologies. Whether a student's research focus is in human, molecular, or developmental genetics;whether in Drosophila, yeast, mouse, human or zebra fish;whether in cloned DNA, cultured cells, model systems or actual families;each student is expected to develop a broad understanding of and appreciation for a range of approaches and topics being pursued in other organisms or specialties. The training program is administered by the Department of Genetics. Students are admitted either through the multi-program Biomedical Sciences Training Program, the Medical Scientist Training Program, or by direct application to the Genetics Department. All first year students perform 3 research rotations and select a laboratory with a research mentor in the Genetics Program by the end of their first year. The program is administered by a Steering Committee consisting of the Director and faculty trainers, each with responsibilities for specific aspects of the program. This integrated training program reflects our commitment to the diversity of genetics as a unifying theme across biology and medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008613-15
Application #
7848861
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Haynes, Susan R
Project Start
1996-07-01
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
15
Fiscal Year
2010
Total Cost
$276,323
Indirect Cost
Name
Case Western Reserve University
Department
Genetics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Hinman, Melissa N; Sharma, Alok; Luo, Guangbin et al. (2014) Neurofibromatosis type 1 alternative splicing is a key regulator of Ras signaling in neurons. Mol Cell Biol 34:2188-97
Zentner, Gabriel E; Balow, Stephanie A; Scacheri, Peter C (2014) Genomic characterization of the mouse ribosomal DNA locus. G3 (Bethesda) 4:243-54
Hinman, Melissa N; Zhou, Hua-Lin; Sharma, Alok et al. (2013) All three RNA recognition motifs and the hinge region of HuC play distinct roles in the regulation of alternative splicing. Nucleic Acids Res 41:5049-61
Balow, Stephanie A; Pierce, Lain X; Zentner, Gabriel E et al. (2013) Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome. Dev Biol 382:57-69
Zentner, Gabriel E; Saiakhova, Alina; Manaenkov, Pavel et al. (2011) Integrative genomic analysis of human ribosomal DNA. Nucleic Acids Res 39:4949-60
Chou, Shih-Wei; Hwang, Philsang; Gomez, Gustavo et al. (2011) Fascin 2b is a component of stereocilia that lengthens actin-based protrusions. PLoS One 6:e14807
Zhou, Hua-Lin; Hinman, Melissa N; Barron, Victoria A et al. (2011) Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner. Proc Natl Acad Sci U S A 108:E627-35
Johnson, Matthew L; Nagengast, Alexis A; Salz, Helen K (2010) PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in Drosophila. PLoS Genet 6:e1000872
Barron, Victoria A; Zhu, Hui; Hinman, Melissa N et al. (2010) The neurofibromatosis type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation. Nucleic Acids Res 38:253-64
Zentner, Gabriel E; Hurd, Elizabeth A; Schnetz, Michael P et al. (2010) CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Hum Mol Genet 19:3491-501

Showing the most recent 10 out of 35 publications