This training grant will support the training of potential academic medical surgeon/scientists in basic research related to trauma in muscle and bone, burn injuries, and wound healing. It will provide basic training in cell physiology, physiology, biomedical engineering, biochemistry and molecular biology. Residents can train in health related areas of investigation and can choose more fundamental research fields (Biophysics, tissue engineering, lipid biochemistry and molecular biology). ? ? There are fourteen members of the program faculty, from the Section of Plastic and Reconstructive Surgery, Department of Surgery, the Department of Pathology (Trauma), Oral/Maxillofacial Surgery, Biomedical Engineering, Biological Material Sciences, and the Biophysics Research Division. These are Dr. Cynthia L. Marcelo, a cell physiologist and her collaborators, Dr. William Richard Dunham, a biophysicist, and Dr. Robert R. Gilmont, a biochemist/molecular biologist. Drs. Dunham and Gilmont are biochemical/biophysical basic scientists. Dr. Daniel Remick is in the Department of Pathology and is a well-funded scientist in the area of tissue damage in trauma. William M. Kuzon is the Section Head of Plastic and Reconstructive Surgery. He is a funded NIH researcher and works in collaboration with Dr. John A. Faulkner and Dr. Paul S. Cederna in the Muscle Mechanics Laboratory Research Consortium and Dr. David J. Mooney in Biomedical Engineering. Dr. Riley S. Rees and his collaborator Dr. Michael G. Franz study wound injury and cytokines. Dr. David J. Smith is the former Section Head of Plastic Surgery, and collaborates in the area of the Trauma and Burn Research. Dr. Steven R. Buchman is a researcher in the area of cranial facial injury in collaboration with Dr. Steven A. Goldstein, a very well-known biomedical engineer and the Director, Center for Biomedical Engineering Research, University of Michigan and Associate Dean for Research and Graduate Studies, University of Michigan Medical School. Dr. Stephen E. Feinberg is an oral surgeon who is NIH funded with his co-investigator, Dr. Marcelo, to design and test tissue composites for use in oral reconstruction. The Grant supports two postdoctoral fellows per year, plus supplies, course work and travel allowances. This grant will support the extensive training of medical doctors to enter research/academic careers. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008616-06A1
Application #
6699119
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Somers, Scott D
Project Start
1997-09-01
Project End
2009-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
6
Fiscal Year
2004
Total Cost
$122,340
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Surgery
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Urlaub, Kevin M; Ettinger, Russell E; Nelson, Noah S et al. (2018) Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg :
Kumar, Nikit; Leonzino, Marianna; Hancock-Cerutti, William et al. (2018) VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites. J Cell Biol 217:3625-3639
Snider, Alicia E; Lynn, Jeremy V; Urlaub, Kevin M et al. (2018) Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg 81:604-608
Harris, Chelsea A; Muller, John-Michael; Shauver, Melissa J et al. (2018) Leveraging the Medical Context to Increase Upper Extremity Reconstruction Among Patients With Tetraplegia: A Qualitative Analysis. Arch Phys Med Rehabil 99:459-467.e1
Frost, Christopher M; Ursu, Daniel C; Flattery, Shane M et al. (2018) Regenerative peripheral nerve interfaces for real-time, proportional control of a Neuroprosthetic hand. J Neuroeng Rehabil 15:108
Harris, Chelsea A; Muller, John-Michael; Shauver, Melissa J et al. (2017) Checkpoints to Progression: Qualitative Analysis of the Personal and Contextual Factors That Influence Selection of Upper Extremity Reconstruction Among Patients With Tetraplegia. J Hand Surg Am 42:495-505.e11
Hashmi, Asra; Khan, Faraz A; Herman, Floyd et al. (2017) A survey of current state of training of plastic surgery residents. BMC Res Notes 10:234
Harris, Chelsea A; Blencowe, Natalie; Telem, Dana A (2017) What is in a Pronoun?: Why Gender-fair Language Matters. Ann Surg 266:932-933
Carey, Edward G; Deshpande, Sagar S; Urlaub, Kevin M et al. (2017) Significant Differences in the Bone of an Isogenic Inbred Versus Nonisogenic Outbred Murine Mandible: A Study in Rigor and Reproducibility. J Craniofac Surg 28:915-919
Donneys, Alexis; Nelson, Noah S; Perosky, Joseph E et al. (2016) Prevention of radiation-induced bone pathology through combined pharmacologic cytoprotection and angiogenic stimulation. Bone 84:245-252

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