The UCSD Genetics Training Program (GTP) is designed to provide advanced training in Genetics and Genomics to predoctoral students beginning in their second graduate year. While several degree-granting programs at UCSD include genetics or genomics components, GTP is the sole point of integration across programs and builds both lateral and vertical cohorts of Ph.D. students interested in the history, practice and future applications of Genetics and Genomics in life and health sciences. Mentor laboratories encompass a broad range of basic science and clinical/translation research aims and span a range of organisms including microbial, plant, experimental animal and human subjects, but share a focus on genetic, epigenetic and genomic mechanisms and approaches. Students who have committed to thesis research in one of these laboratories can enter the training program and may be selected for support by this training grant. Students in the program take an advanced genetics curriculum that cuts across traditional graduate programs in several participating schools, division and departments at UCSD. Trainees take required graduate level courses in Genetics, Quantitative Methods, and participate in a weekly journal club attended in at least graduate years 2-4. The journal club includes rotating topics in contemporary genetics or classic, landmark papers relevant to the intellectual development of the field. Topics are selected by students, in consultation with participating faculty. A program-wide annual retreat, organized by year 5 students and a standing faculty committee, includes invited outside speakers, research presentations by program faculty and students. GTP has 33 students currently in training, for whom we are requesting 16 training grant slots.

Public Health Relevance

The UCSD Genetics Training Program rigorously prepares an exceptional pool of students for professional careers in basic and applied research in life and health sciences. Our graduates have work in academic institutions, non-profit research institutions, biotechnology and drug research companies, and business firms that promote the development of health sciences companies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008666-16
Application #
8697056
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Haynes, Susan R
Project Start
1998-07-01
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Solomon, Terry; Lapek Jr, John D; Jensen, Søren Beck et al. (2018) Identification of Common and Rare Genetic Variation Associated With Plasma Protein Levels Using Whole-Exome Sequencing and Mass Spectrometry. Circ Genom Precis Med 11:e002170
Ghosh, Shereen G; Becker, Kerstin; Huang, He et al. (2018) Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet 103:431-439
Ryan, Genevieve E; Malik, Shaddy; Mellon, Pamela L (2018) Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. Endocrinology 159:1734-1747
Antaki, Danny; Brandler, William M; Sebat, Jonathan (2018) SV2: accurate structural variation genotyping and de novo mutation detection from whole genomes. Bioinformatics 34:1774-1777
Bui, Nam; Huang, Justin K; Bojorquez-Gomez, Ana et al. (2018) Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation. Mol Cancer Ther 17:1585-1594
Searle, Naomi E; Pillus, Lorraine (2018) Critical genomic regulation mediated by Enhancer of Polycomb. Curr Genet 64:147-154
Fong, Lauren K; Yang, Max M; Dos Santos Chaves, Rodrigo et al. (2018) Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-? clearance in human astrocytes. J Biol Chem 293:11341-11357
Hsu, Cynthia L; Lee, Elian X; Gordon, Kara L et al. (2018) MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. Nat Commun 9:942
Cowell, Annie N; Istvan, Eva S; Lukens, Amanda K et al. (2018) Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science 359:191-199
Wheeler, Emily C; Van Nostrand, Eric L; Yeo, Gene W (2018) Advances and challenges in the detection of transcriptome-wide protein-RNA interactions. Wiley Interdiscip Rev RNA 9:

Showing the most recent 10 out of 214 publications