This pre-doctoral training program at the Chemistry-Biology Interface involves 29 training faculty from three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, and Biochemistry, Molecular Biology and Biophysics (BMBB). It seeks to provide a research training experience to its trainees that crosses the traditional disciplinary boundaries of Chemistry and Biology. Common research themes include: Biocatalysis and Biomolecular Design (Distefano, Kauzlauskus, Lipscomb, Ohlendorf, Schmidt-Dannert, Wackett, Wagner, Wilmot, York), Therapeutic Agents (Amin, Bernlohr, Distefano, Georg, Hoye, Mansky, Sturla, Tretyakova, Wagner, Xing), Chemistry of Disease (Arriaga, Bernlohr, Mansky, Murphy, Sturla, Tretyakova, Wagner, Walters, Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Tolman, Wackett, Wilmot, York), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Taton, Tretyakova, Thomas, Veglia, Walters). The research groups of the training faculty are all well supported and well equipped. There are extensive facilities for peptide and oligonucleotide synthesis, biofermentation, mass spectrometry, X-ray crystallography, NMR, and computation. Support is requested for 8 trainees each year of the program, each to be supported for a two-year period. Prospective trainees will generally have undergraduate degrees in chemistry, biochemistry or oiology. They will be expected to obtain thorough grounding in chemistry, as well as molecular biology and biochemistry. The particular emphasis of this training program is a focus on research problems that address synthetic/mechanistic questions in biological systems, with the goal of understanding and influencing key at the molecular level. The defining characteristic for this training program will be to allow first-rate students to grow into accomplished professionals both in their primary area of interest and in a complementary field. Students will choose from a menu of required coursework in chemistry and biology. In addition, laboratory rotations, a chemical biology colloquium, an annual symposium, journal clubs, and joint group meetings will enrich the graduate experience of the trainees.
(Seeinstructions): The CBITG trainers and their trainees collectively carry out research on fundamental questions related to current important problems in public health. These include understanding how cancers are initiated in the cell, how obesity and diabetes develop and how a muscle works, designing and developing new drugs and assay probes against cancer, HIV, and Alzheimer's disease, and understanding how chemicals are broken down in the environment.
|Gee, Clifford T; Arntson, Keith E; Koleski, Edward J et al. (2018) Dual Labeling of the CBP/p300 KIX Domain for 19 F?NMR Leads to Identification of a New Small-Molecule Binding Site. Chembiochem 19:963-969|
|Martin, Peter D; James, Zachary M; Thomas, David D (2018) Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban. Biophys J 114:2573-2583|
|Diaz-Rodriguez, Veronica; Hsu, Erh-Ting; Ganusova, Elena et al. (2018) a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity. Bioconjug Chem 29:316-323|
|Divakaran, Anand; Talluri, Siva K; Ayoub, Alex M et al. (2018) Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J Med Chem 61:9316-9334|
|Komor, Anna J; Jasniewski, Andrew J; Que, Lawrence et al. (2018) Diiron monooxygenases in natural product biosynthesis. Nat Prod Rep 35:646-659|
|Muratore, Katherine A; Najt, Charles P; Livezey, Nicholas M et al. (2018) Sizing lipid droplets from adult and geriatric mouse liver tissue via nanoparticle tracking analysis. Anal Bioanal Chem 410:3629-3638|
|Olson, Erik D; Musier-Forsyth, Karin (2018) Retroviral Gag protein-RNA interactions: Implications for specific genomic RNA packaging and virion assembly. Semin Cell Dev Biol :|
|Buonomo, Joseph A; Eiden, Carter G; Aldrich, Courtney C (2018) Scalable Synthesis of Hydrido-Disiloxanes from Silanes: A One-Pot Preparation of 1,3-Diphenyldisiloxane from Phenylsilane. Synthesis (Stuttg) 50:278-281|
|Jensen, Matthew R; Goblirsch, Brandon R; Esler, Morgan A et al. (2018) The role of OleA His285 in orchestration of long-chain acyl-coenzyme A substrates. FEBS Lett 592:987-998|
|Kotandeniya, D; Seiler, C L; Fernandez, J et al. (2018) Can 5-methylcytosine analogues with extended alkyl side chains guide DNA methylation? Chem Commun (Camb) 54:1061-1064|
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