The goals of the proposed training program are to recruit and train outstanding graduate students and to prepare them for productive careers in science. The trainers in the "Molecular and Cellular Biology at Dartmouth" Training Program (MCBD) include 53 of the 69 faculty in Dartmouth's largest life science graduate program, the Molecular and Cellular Biology (MCB) Graduate Program. The MCB Graduate Program is an interdepartmental, interdisciplinary program with 137 students. Research areas include biotechnology, cell biology, computational biology, developmental biology, immunology, molecular pathogenesis, neurobiology, regulation of gene expression, signal transduction and cellular metabolism, and structural biology. MCB Graduate Program students and faculty come from nine departments at Dartmouth College, Dartmouth Medical School, and the Thayer School of Engineering. Many faculty in the MCB Graduate Program have long and established training records. The MCBD Training Program faculty was selected based on the strength of their research programs, their commitment to training predoctoral students, and their willingness to participate in the various activities of the MCB Graduate Program. Trainees must satisfy the MCB Graduate Program requirements for the Ph.D., which include three research rotations, a three-term core course, three elective courses, one term of teaching, participation in journal clubs and seminars, training in the responsible conduct of research, a qualifying exam, a yearly Research in Progress presentation, and a thesis defense. The MCB Graduate Program regularly matriculates approximately 25-30 students per year. New efforts to recruit underrepresented minority (URM) students, that include a highly successful Department of Defense-funded Summer Undergraduate Research Program (SURF), were implemented during the current funding period. As a result of these efforts the number of URM students in the MCB Graduate Program increased from one to four, and will further double upon matriculation of the Fall 2007 class. Training the next generation of scientists is essential for maintaining and improving the economy of our country and the health of its citizens. Funds from this program will be used to support young scientists during their training, and to help prepare the next generation of scientists and teachers for productive careers.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
Schools of Medicine
United States
Zip Code
Kuchma, S L; Delalez, N J; Filkins, L M et al. (2015) Cyclic di-GMP-mediated repression of swarming motility by Pseudomonas aeruginosa PA14 requires the MotAB stator. J Bacteriol 197:420-30
Bridges, Andrew A; Gladfelter, Amy S (2014) Fungal pathogens are platforms for discovering novel and conserved septin properties. Curr Opin Microbiol 20:42-8
Deng, Lin; Kabeche, Ruth; Wang, Ning et al. (2014) Megadalton-node assembly by binding of Skb1 to the membrane anchor Slf1. Mol Biol Cell 25:2660-8
Kabeche, Ruth; Roguev, Assen; Krogan, Nevan J et al. (2014) A Pil1-Sle1-Syj1-Tax4 functional pathway links eisosomes with PI(4,5)P2 regulation. J Cell Sci 127:1318-26
Roy, Sarah H; Tobin, David V; Memar, Nadin et al. (2014) A complex regulatory network coordinating cell cycles during C. elegans development is revealed by a genome-wide RNAi screen. G3 (Bethesda) 4:795-804
Ballok, Alicia E; Filkins, Laura M; Bomberger, Jennifer M et al. (2014) Epoxide-mediated differential packaging of Cif and other virulence factors into outer membrane vesicles. J Bacteriol 196:3633-42
Hatch, Anna L; Gurel, Pinar S; Higgs, Henry N (2014) Novel roles for actin in mitochondrial fission. J Cell Sci 127:4549-60
Guo, Bingqian; Gurel, Pinar S; Shu, Rui et al. (2014) Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR. Chem Commun (Camb) 50:12037-9
George, Carolyn M; Bozler, Julianna; Nguyen, Huy Q et al. (2014) Condensins are Required for Maintenance of Nuclear Architecture. Cells 3:865-82
Amacher, Jeanine F; Cushing, Patrick R; Brooks 3rd, Lionel et al. (2014) Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses. Structure 22:82-93

Showing the most recent 10 out of 76 publications