Support is requested to continue a multidisciplinary predoctoral training program in Molecular and Cellular Biology at Dartmouth. The trainees and trainers in the """"""""Molecular and Cellular Biology at Dartmouth"""""""" Training Program (MCBD) are selected from Dartmouth's largest and most diverse life science graduate program, the Molecular and Cellular Biology (MCB) graduate program. The MCB graduate program is an interdepartmental, interdisciplinary program with 155 students that spans nine different academic departments at Dartmouth College, Dartmouth Medical School, and the Thayer School of Engineering. The MCB graduate program regularly matriculates 25-30 students per year who are selected from highly qualified national and international pools of applicants that are rich in both ethnic and racial diversity. Eight predoctoral trainees for the MCBD Training Program are selected for two years of support based upon their academic qualifications and must satisfy the diverse and rigorous MCB graduate program curriculum that includes a three-term core course, three 10-week research rotations, three elective courses, one term of teaching, participation in journal clubs and seminars, training in responsible conduct of research, a written and oral qualifying exam, a yearly Research in Progress seminar, and the completion of a significant research project that forms the foundation of a written thesis that is orally defended. Faculty in the MCBD Training Program include 48 extramurally funded faculty who are elected based on the strength of their research programs and their demonstrated commitment to participating in the activities necessary for effective predoctoral training. The research areas of the faculty are broad and interdisciplinary to support the development of the trainees and include bioinformatics, cell biology, developmental biology, immunology, molecular pathogenesis, neurobiology, gene expression, signal transduction, cellular metabolism, proteomics, and structural biology. It is through the dedication and expertise of the faculty and the rigorous curriculum that the MCBD Training Program reaches the goal of recruiting and training the next generation of outstanding young scientists for productive careers in the biomedical sciences.

Public Health Relevance

This proposal seeks funds to continue a multidisciplinary predoctoral training program in Molecular and Cellular Biology at Dartmouth. The goals of this training program are to recruit and train outstanding graduate students and to prepare them for productive careers in science. Training the next generation of scientists is essential for maintaining and improving the economy of our country and the health of its citizens. This training program will support young scientists during their training that strives to prepare them for productive careers as researchers and teachers in the biomedical sciences.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Gindhart, Joseph G
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Dartmouth College
Schools of Medicine
United States
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Baker, Amy E; Diepold, Andreas; Kuchma, Sherry L et al. (2016) PilZ Domain Protein FlgZ Mediates Cyclic Di-GMP-Dependent Swarming Motility Control in Pseudomonas aeruginosa. J Bacteriol 198:1837-46
Mehta, Shalin B; McQuilken, Molly; La Riviere, Patrick J et al. (2016) Dissection of molecular assembly dynamics by tracking orientation and position of single molecules in live cells. Proc Natl Acad Sci U S A 113:E6352-E6361
Kowalski, Caitlin H; Beattie, Sarah R; Fuller, Kevin K et al. (2016) Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence. MBio 7:
Varn, Frederick S; Andrews, Erik H; Mullins, David W et al. (2016) Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles. Nat Commun 7:10248
Varn, Frederick S; Mullins, David W; Arias-Pulido, Hugo et al. (2016) Adaptive immunity programmes in breast cancer. Immunology :
Ries, Laure N A; Beattie, Sarah R; Espeso, Eduardo A et al. (2016) Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans. Genetics 203:335-52
Bridges, Andrew A; Jentzsch, Maximilian S; Oakes, Patrick W et al. (2016) Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton. J Cell Biol 213:23-32
Pattison, Jillian M; Posternak, Valeriya; Cole, Michael D (2016) Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk. Mol Cancer Res 14:1078-1086
Kitamura, Seiya; Hvorecny, Kelli L; Niu, Jun et al. (2016) Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa. J Med Chem 59:4790-9
Ung, Matthew H; Wang, George L; Varn, Frederick S et al. (2016) Application of pharmacologically induced transcriptomic profiles to interrogate PI3K-Akt-mTOR pathway activity associated with cancer patient prognosis. Oncotarget :

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