This application requests continued support of the Medical Scientist Training Program at the Medical University of South Carolina. The major goal is to train the next generation of physician-scientists who will choose a career that will conduct research that integrates both the basic and clinical sciences to improve human health and treat diseases. The program was originally founded in 1980 and has steadily grown to its current size of 56 students, with 37% females. Career outcomes of our 100 graduates to date are: 3 professors, all holding endowed chairs, 7 associate professors, 15 assistant professors, 6 conducting research in industry, 10 clinical professors/instructors, 14 in private practice, 43 in training and 2 deceased. For the last 10 years the attrition rate was 5%. The applicant pool continues to be strong with a 58% increase over the past five years. This increase in our trainee candidate pool reflects a combination of MUSC's exceptional research environment, our MSTP students'outstanding accomplishments, and the program's national recruitment efforts, which includes personal contacts and a recruitment letter with brochure sent to students who took the MCAT and received a score of >32 or better. The growth in the quality and quantity of our applicants provides the basis for the requested increase in positions from 8 to 9 per year. Our program is designed along the classical 2,4,2 year paradigm, however, there is considerable flexibility built into it. In addition to rigorous basic science research training and medical schol, trainees gain experiences in translational research via the Translational Sciences Clinic, a month in the Clinical and Translational Research Center and the Translational Medicine Seminar series. The objectives for the next phase are to: 1) continue the rigorous research training in areas of biomedical research by collaborative and highly accomplished faculty with exceptional records of training and research, 2) offer a training program that challenges students to think independently and critically, 3) conduct the training in a challenging, interactie environment that embraces basic, clinical and translational sciences, 4) utilize individualized development plans to enhance the training experience, and 5) continue the rigorous and formal evaluation of the program that uses both quantitative and qualitative data to ensure the most rigorous, effective and efficient training.

Public Health Relevance

This training program supports students pursuing the dual MD/PhD degree who will receive rigorous and directed training in the basic and clinical sciences and exposure to translation research. They are expected to be future academic physician-scientists able to conduct both basic and clinical/translational research. They will be capable of bridging the basic and clinical sciences in order to perform research at the cutting edge and become leaders in their respective fields.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Program Officer
Preusch, Peter
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Medicine
United States
Zip Code
Williams, N R; Bentzley, B S; Sahlem, G L et al. (2017) Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson's disease. Acta Neurol Scand 135:407-411
Harmon, Jennifer L; Gibbs, Whitney S; Whitaker, Ryan M et al. (2017) Striatal Mitochondrial Disruption following Severe Traumatic Brain Injury. J Neurotrauma 34:487-494
Neitzke, Daniel J; Bowers, Jacob S; Andrijauskaite, Kristina et al. (2017) Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis. Cancer Immunol Immunother 66:737-751
McKinnon, Emilie T; Fridriksson, Julius; Glenn, G Russell et al. (2017) Structural plasticity of the ventral stream and aphasia recovery. Ann Neurol 82:147-151
Bowers, Jacob S; Majchrzak, Kinga; Nelson, Michelle H et al. (2017) PI3K? Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells. Front Immunol 8:1221
McKinnon, Emilie T; Jensen, Jens H; Glenn, G Russell et al. (2017) Dependence on b-value of the direction-averaged diffusion-weighted imaging signal in brain. Magn Reson Imaging 36:121-127
Smith, Alexander C W; Scofield, Michael D; Heinsbroek, Jasper A et al. (2017) Accumbens nNOS Interneurons Regulate Cocaine Relapse. J Neurosci 37:742-756
Malik, Brian T; Byrne, Katelyn T; Vella, Jennifer L et al. (2017) Resident memory T cells in the skin mediate durable immunity to melanoma. Sci Immunol 2:
Summers, Philipp M; Hartmann, David A; Hui, Edward S et al. (2017) Functional deficits induced by cortical microinfarcts. J Cereb Blood Flow Metab 37:3599-3614
Bowers, Jacob S; Nelson, Michelle H; Majchrzak, Kinga et al. (2017) Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion. JCI Insight 2:e90772

Showing the most recent 10 out of 105 publications