The Department of Biochemistry & Molecular Biology, and the Department of Chemistry at The University of Chicago propose an interdisciplinary predoctoral training program directed at the interface of the chemical and biological sciences. The program will emphasize cross-training and will have a synthetic and mechanistic focus. Predoctoral students will be registered either in the Department of Biochemistry & Molecular Biology in the Biological Sciences Division or in the Department of Chemistry in the Physical Sciences Division, but will pursue through elective coursework a program satisfying the requirements of the M.S. degree in the other division while completing all requirements for the Ph.D. degree in their home division. This program will thus ensure cross-training in the language and research methods of chemistry and biology. In addition, predoctoral students will have at least one research rotation in the laboratory of a participating faculty member in the other division prior to selecting a research advisor. The participating faculty, with established research programs in the general areas of bioorganic, bioinorganic, and biophysical chemistry, as well as synthetic and mechanistic organic chemistry, are often engaged in a variety of collaborative projects involving both chemical and biological techniques. The training program will emphasize the application of concepts of organic, inorganic and physical chemistry to biological problems. The proposed program does not overlap with other NRSA training program currently at The University of Chicago and is a new development in the graduate curricula of both departments. Funds are requested for a predoctoral trainee group of six(6) students with four years of support each, building to a steady-state population of 24 students in the fourth year of the proposal.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Rogers, Michael E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
Schools of Medicine
United States
Zip Code
Clark, Wesley C; Evans, Molly E; Dominissini, Dan et al. (2016) tRNA base methylation identification and quantification via high-throughput sequencing. RNA 22:1771-1784
Durak, Landon J; Payne, James T; Lewis, Jared C (2016) Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization. ACS Catal 6:1451-1454
Andorfer, Mary C; Park, Hyun June; Vergara-Coll, Jaylie et al. (2016) Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds. Chem Sci 7:3720-3729
Srivastava, Poonam; Yang, Hao; Ellis-Guardiola, Ken et al. (2015) Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation. Nat Commun 6:7789
Weissman, Benjamin P; Li, Nan-Sheng; York, Darrin et al. (2015) Heavy atom labeled nucleotides for measurement of kinetic isotope effects. Biochim Biophys Acta 1854:1737-45
Gu, Yifan; Ellis-Guardiola, Ken; Srivastava, Poonam et al. (2015) Preparation, Characterization, and Oxygenase Activity of a Photocatalytic Artificial Enzyme. Chembiochem :
Payne, James T; Poor, Catherine B; Lewis, Jared C (2015) Directed evolution of RebH for site-selective halogenation of large biologically active molecules. Angew Chem Int Ed Engl 54:4226-30
Lee, Jung-Hoon; Gibson, Kyle J; Chen, Gang et al. (2015) Bipyramid-templated synthesis of monodisperse anisotropic gold nanocrystals. Nat Commun 6:7571
Huang, Hao; Suslov, Nikolai B; Li, Nan-Sheng et al. (2014) A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore. Nat Chem Biol 10:686-91
Sha, Fern; Gencer, Emel Basak; Georgeon, Sandrine et al. (2013) Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc Natl Acad Sci U S A 110:14924-9

Showing the most recent 10 out of 27 publications