The Department of Biochemistry &Molecular Biology (BMB) and the Department of Chemistry (Chem) at The University of Chicago propose continuation and expansion of an interdisciplinary, predoctoral training program directed at the interface of the chemical and biological sciences. The program aims to educate and train the next generation biomedical scholars by promoting cross-disciplinary research with a synthetic and mechanistic focus while maintaining depth in the core discipline. The program has grown, strengthened and matured through recruitment of outstanding faculty and students and introduction of new courses in interdisciplinary science. The training faculty that comprise the teaching component of the program consists of nine faculty with appointments in BMB (two with joint appointments in Chemistry), eight faculty in Chemistry, and two in the Ben May Department for Cancer Research. Three new faculty have been recruited to the program in the current funding cycle, with two new hires poised to join the faculty in the 2010-2011 academic year. Strategies to develop cross- disciplinary training include: (1) satisfactory completion of two courses in the department of the other scientific discipline;(2) cross-disciplinary research, achieved either as an elective research rotation in the laboratory of a participating faculty member in the other discipline program, or as a collaborative research rotation aligned with the trainee's thesis research;and (3) participation in a series of monthly meetings throughout the academic year designated as "Discussions at the Interface of Chemistry &Biology" to gain acquaintance with theoretical concepts and methods. The broad scope of the interdisciplinary research interests of the faculty, strengthened through collaborative research and teaching, ensures a wide variety of opportunities for meaningful cross- training. With its commitment to interdisciplinary research and broad faculty support, the program offers a supportive environment for training at the cutting-edge of research at the interface of chemistry and biology.

Public Health Relevance

A cross-disciplinary, predoctoral program is proposed with the goal of training future biomedical scientists to develop competence in both chemistry and biology and to enable biologists and chemists to work together. Scholars with skills in both disciplines will be poised to make future breakthrough discoveries in human health research.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008720-12
Application #
8294565
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Fabian, Miles
Project Start
1999-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
12
Fiscal Year
2012
Total Cost
$223,273
Indirect Cost
$10,613
Name
University of Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Clark, Wesley C; Evans, Molly E; Dominissini, Dan et al. (2016) tRNA base methylation identification and quantification via high-throughput sequencing. RNA 22:1771-1784
Durak, Landon J; Payne, James T; Lewis, Jared C (2016) Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization. ACS Catal 6:1451-1454
Andorfer, Mary C; Park, Hyun June; Vergara-Coll, Jaylie et al. (2016) Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds. Chem Sci 7:3720-3729
Srivastava, Poonam; Yang, Hao; Ellis-Guardiola, Ken et al. (2015) Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation. Nat Commun 6:7789
Weissman, Benjamin P; Li, Nan-Sheng; York, Darrin et al. (2015) Heavy atom labeled nucleotides for measurement of kinetic isotope effects. Biochim Biophys Acta 1854:1737-45
Gu, Yifan; Ellis-Guardiola, Ken; Srivastava, Poonam et al. (2015) Preparation, Characterization, and Oxygenase Activity of a Photocatalytic Artificial Enzyme. Chembiochem :
Payne, James T; Poor, Catherine B; Lewis, Jared C (2015) Directed evolution of RebH for site-selective halogenation of large biologically active molecules. Angew Chem Int Ed Engl 54:4226-30
Lee, Jung-Hoon; Gibson, Kyle J; Chen, Gang et al. (2015) Bipyramid-templated synthesis of monodisperse anisotropic gold nanocrystals. Nat Commun 6:7571
Huang, Hao; Suslov, Nikolai B; Li, Nan-Sheng et al. (2014) A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore. Nat Chem Biol 10:686-91
Sha, Fern; Gencer, Emel Basak; Georgeon, Sandrine et al. (2013) Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc Natl Acad Sci U S A 110:14924-9

Showing the most recent 10 out of 27 publications