The Department of Biochemistry & Molecular Biology (BMB) and the Department of Chemistry (Chem) at The University of Chicago propose continuation and expansion of an interdisciplinary, predoctoral training program directed at the interface of the chemical and biological sciences. The program aims to educate and train the next generation biomedical scholars by promoting cross-disciplinary research with a synthetic and mechanistic focus while maintaining depth in the core discipline. The program has grown, strengthened and matured through recruitment of outstanding faculty and students and introduction of new courses in interdisciplinary science. The training faculty that comprise the teaching component of the program consists of eleven faculty with appointments in BMB (two with joint appointments in Chemistry), nine faculty in Chemistry (one with a joint appointment in BMB), and two in the Ben May Department for Cancer Research. Seven new faculty members have been recruited to the program in the current funding cycle, with one new hire poised to join the faculty in the 2015-2016 academic year. Strategies to develop cross-disciplinary training include: (1) satisfactory completion of a course in the department of the other scientific discipline; (2) cross-disciplinary research, achieved either as an elective research rotation in th laboratory of a participating faculty member in the other discipline program, or as a collaborative research rotation aligned with the trainee's thesis research; (3) participation in a series of monthly meetings throughout the academic year designated as Discussions at the Interface of Chemistry & Biology to gain acquaintance with theoretical concepts and methods, and (4) participation in two annual half-day events: a CBI Minisymposium and an in-house retreat. The UChicago CBI program seeks to 1) recruit highly motivated students and equip them with the skills that will be needed to recognize and solve the major problems in biomedical science in the coming decades, 2) provide future educators in this discipline, and 3) fulfill health-related positions in academia, industry, public policy, education, and law, requiring a sophisticated appreciation for chemical biological rationales and methods. The broad scope of the interdisciplinary research interests of the faculty, strengthened through collaborative research and teaching, ensures a wide variety of opportunities for meaningful cross-training. With its commitment to interdisciplinary research and broad faculty support, the program offers a supportive environment for training at the cutting-edge of research at the interface of chemistry and biology.

Public Health Relevance

A cross-disciplinary, predoctoral program is proposed with the goal of training future biomedical scientists to develop competence in both chemistry and biology and to enable biologists and chemists to work together. Scholars with skills in both disciplines will be poised to make future breakthrough discoveries in human health research, provide future educators in this discipline, and fulfill health-related positions in our society.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008720-16
Application #
9073990
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Fabian, Miles
Project Start
1999-07-01
Project End
2021-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
16
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Yang, Hao; Swartz, Alan M; Park, Hyun June et al. (2018) Evolving artificial metalloenzymes via random mutagenesis. Nat Chem 10:318-324
Wang, Zongan; Jumper, John M; Wang, Sheng et al. (2018) A Membrane Burial Potential with H-Bonds and Applications to Curved Membranes and Fast Simulations. Biophys J 115:1872-1884
Payne, James T; Butkovich, Paul H; Gu, Yifan et al. (2018) Enantioselective Desymmetrization of Methylenedianilines via Enzyme-Catalyzed Remote Halogenation. J Am Chem Soc 140:546-549
Riback, Joshua A; Bowman, Micayla A; Zmyslowski, Adam et al. (2018) Response to Comment on ""Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water"". Science 361:
Andorfer, Mary C; Lewis, Jared C (2018) Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis. Annu Rev Biochem 87:159-185
Ni, Kaiyuan; Lan, Guangxu; Chan, Christina et al. (2018) Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun 9:2351
Richter, Uwe; Evans, Molly E; Clark, Wesley C et al. (2018) RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis. Nat Commun 9:3966
Andorfer, Mary C; Grob, Jonathan E; Hajdin, Christine E et al. (2017) Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling. ACS Catal 7:1897-1904
Li, Gang; Montgomery, Jeffrey E; Eckert, Mark A et al. (2017) An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells. Nat Commun 8:1775
Pu, Jinyue; Zinkus-Boltz, Julia; Dickinson, Bryan C (2017) Evolution of a split RNA polymerase as a versatile biosensor platform. Nat Chem Biol 13:432-438

Showing the most recent 10 out of 43 publications