The goal of the Molecular Biology Program at the University of Colorado Denver Anschutz Medical Campus is to train outstanding research scientists and academicians who will become future leaders in their chosen fields and disciplines. To accomplish this goal we carefully select high quality students with strong academic records and a demonstrated aptitude, commitment and passion for research. The training program is flexible and highly student orientated to meet individual needs, but at the same time has a rigorous curriculum, sets high standards and is very well organized. Molecular Biology is designed as a 5-6 year program with the first year devoted to challenging course work and laboratory rotations, the second year to the development of a research hypothesis, and the remaining years to completion of the thesis research project under the guidance of a training faculty mentor and thesis committee. To further develop research skills, students at all stages of the curriculum participate in additional program specific activities including a weekly seminar series, roundtable discussions, the annual mini-courses and our retreat. Our curriculum strongly emphasizes the development of critical and creative independent thinking, scientific communication skills, and professional/responsible conduct. A significant strength of the program is its outstanding and highly interactive faculty from 11 different departments who are deeply committed to graduate education and to the Program. The recent infusion of new junior and senior faculty has increased the multi-disciplinary aspects of our program, with a greater representation of research with human health relevance, providing new training opportunities in areas such as stem cells, human pathogens, immunity, development, radiation biology, and protein dynamics. Cooperation between our Program and the umbrella recruitment has ensured large, high quality and diverse applicant pools and students admitted. The training success of our program is evident in the high quality postdoctoral, faculty and industry positions obtained by our students. Given the strengthened recruitment programs and our demonstrated ability to train high quality students, we are requesting an increase in student positions to be supported by this training grant from 5 to 6/yr.

Public Health Relevance

The future of biomedical and molecular biological research in the U.S. is dependent on the training of high quality, passionate PhD scientists who have learned to think critically and independently. Our program strongly fosters the development of critically minded, dedicated researchers who can communicate effectively and who appreciate the human health implications of their studies.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Colorado Denver
Schools of Medicine
United States
Zip Code
Zukowski, Alexis; Al-Afaleq, Nouf Omar; Duncan, Emily D et al. (2018) Recruitment and allosteric stimulation of a histone-deubiquitinating enzyme during heterochromatin assembly. J Biol Chem 293:2498-2509
Tapscott, Timothy; Kim, Ju-Sim; Crawford, Matthew A et al. (2018) Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region. Sci Rep 8:9465
Vartuli, Rebecca L; Zhou, Hengbo; Zhang, Lingdi et al. (2018) Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation. J Clin Invest 128:2535-2550
Zukowski, Alexis; Johnson, Aaron M (2018) The interplay of histone H2B ubiquitination with budding and fission yeast heterochromatin. Curr Genet 64:799-806
Cherry, Patrick D; White, Laura K; York, Kerri et al. (2018) Genetic bypass of essential RNA repair enzymes in budding yeast. RNA 24:313-323
Guarnieri, A L; Towers, C G; Drasin, D J et al. (2018) The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L. Oncogene 37:3879-3893
Roberts, Justin T; Patterson, Dillon G; King, Valeria M et al. (2018) ADAR Mediated RNA Editing Modulates MicroRNA Targeting in Human Breast Cancer. Processes (Basel) 6:
Ransom, Monica; Bryan, D Suzi; Hesselberth, Jay R (2018) High-Resolution Mapping of Modified DNA Nucleobases Using Excision Repair Enzymes. Methods Mol Biol 1672:63-76
Holliday, Michael Joseph; Camilloni, Carlo; Armstrong, Geoffrey Stuart et al. (2017) Networks of Dynamic Allostery Regulate Enzyme Function. Structure 25:276-286
Cicchini, Louis; Blumhagen, Rachel Z; Westrich, Joseph A et al. (2017) High-Risk Human Papillomavirus E7 Alters Host DNA Methylome and Represses HLA-E Expression in Human Keratinocytes. Sci Rep 7:3633

Showing the most recent 10 out of 76 publications