In the Leadership in Pharmaceutical Biotechnology training program, students are provided a broad-based education that cuts across traditional departmental and field-of-study boundaries, blending disciplines of pharmaceutical science, chemical engineering, biochemistry and chemistry. This program operates in close collaboration industry at both the local and national levels, and is currently supported by a broad-based group of corporate sponsors that leverage NIH support to provide interdisciplinary education in pharmaceutical biotechnology to graduate students in the University of Colorado's Departments of Chemical and Biological Engineering, Pharmaceutical Sciences, and Chemistry and Biochemistry. The Leadership in Pharmaceutical Biotechnology training program has seven major thrusts: 1. Lecture and laboratory coursework designed to provide a broad-based education in pharmaceutical biotechnology 2. Laboratory rotations 3. An industrial mentor program designed to enhance both recruitment and retention of students 4. A summer internship program with our industrial collaborators 5. Interdisciplinary thesis research 6. Leadership activities, including training in research ethics 7. Seminars and symposia. These seven thrusts enable students to be educated in practical issues in pharmaceutical biotechnology (e.g., intellectual property issues, regulatory affairs and basic business concepts) as well as multidisciplinary scientific ones. This prepares students to perform well when they take subsequent positions in industry, academia, or government. To make sure that our research is rooted in practical problems, we rely heavily on our industrial colleagues as a source of new challenges that we may attempt to address. Students benefit from experiential training in non-academic settings, gaining an appreciation of the ever-changing biomedical and pharmaceutical industries. We incorporate active participation of our industrial mentors, industrial internships, and industrial seminar speakers to achieve this non-academic training.

Public Health Relevance

The Leadership in Pharmaceutical Biotechnology training Program provides graduate students with the interdisciplinary research training needed to produce industry and academic leaders. These leaders have the broad-based biotechnology knowledge needed to translate advances in biosciences and bioengineering into new therapeutic products for the benefit of human health.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008732-14
Application #
8692803
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gerratana, Barbara
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80303
Bis, Regina L; Singh, Surinder M; Cabello-Villegas, Javier et al. (2015) Role of benzyl alcohol in the unfolding and aggregation of interferon ?-2a. J Pharm Sci 104:407-15
Bis, Regina L; Stauffer, Tara M; Singh, Surinder M et al. (2014) High yield soluble bacterial expression and streamlined purification of recombinant human interferon ?-2a. Protein Expr Purif 99:138-46
Bis, Regina L; Mallela, Krishna M G (2014) Antimicrobial preservatives induce aggregation of interferon alpha-2a: the order in which preservatives induce protein aggregation is independent of the protein. Int J Pharm 472:356-61
McKinnon, Daniel D; Domaille, Dylan W; Cha, Jennifer N et al. (2014) Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3D cell culture systems. Adv Mater 26:865-72
Lewis, Karen A; Pfaff, Danielle A; Earley, Jennifer N et al. (2014) The tenacious recognition of yeast telomere sequence by Cdc13 is fully exerted by a single OB-fold domain. Nucleic Acids Res 42:475-84
Christie, Merry; Torres, Raul M; Kedl, Ross M et al. (2014) Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration. J Pharm Sci 103:128-39
Chang, Le; Podoll, Jessica D; Wang, Wei et al. (2014) Structure-activity relationship studies of the tricyclic indoline resistance-modifying agent. J Med Chem 57:3803-17
MacConaghy, Kelsey I; Geary, Christopher I; Kaar, Joel L et al. (2014) Photonic crystal kinase biosensor. J Am Chem Soc 136:6896-9
Carter, Kyle P; Young, Alexandra M; Palmer, Amy E (2014) Fluorescent sensors for measuring metal ions in living systems. Chem Rev 114:4564-601
Podoll, Jessica D; Liu, Yongxiang; Chang, Le et al. (2013) Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to *-lactam antibiotics. Proc Natl Acad Sci U S A 110:15573-8

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