The mission of this program is the training of graduate students toward the Ph.D. degree in biochemistry, molecular biology, and cell biology. The long term goal is to produce biomedical researchers of the future. The training program's major component is laboratory research. The research areas covered in this program include such fields as mechanistic enzymology, signal transduction, gene expression, virology, cell biology, and a very strong structural biology component. Training will begin in a classroom environment through formal course work, but the goal is to move students away from dependency on classroom education to become independent thinkers capable of advanced problem solving skills. The trainers chosen for this program include Purdue Biochemistry & Molecular Biology (BMP) Program faculty who have research funding from a major national source. We anticipate the training of 6 graduate students annually through the proposed program. All trainees will have at least a B.S. or equivalent in a field such as biochemistry, chemistry or biology. Most of our trainees have had some form of laboratory experience as an undergraduate or perhaps as a laboratory technician. We feel that laboratory experience is an important indicator of motivation and persistence for conducting thesis research. Our students complete Ph.D. requirements in an average of 5 years after their arrival.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Purdue University
Schools of Earth Sciences/Natur
West Lafayette
United States
Zip Code
Wilson, Kristy J; Mill, Christopher P; Gallo, Richard M et al. (2012) The Q43L mutant of neuregulin 2? is a pan-ErbB receptor antagonist. Biochem J 443:133-44
Torres-Altoro, Melissa I; White, Kellie J; Rodriguez, Gustavo J et al. (2008) Helix XI contributes to the entrance of the serotonin transporter permeation pathway. Protein Sci 17:1761-70
Wilson, Kristy J; Mill, Christopher P; Cameron, Elizabeth M et al. (2007) Inter-conversion of neuregulin2 full and partial agonists for ErbB4. Biochem Biophys Res Commun 364:351-7
Zullo, Alfred J; Benlagha, Kamel; Bendelac, Albert et al. (2007) Sensitivity of NK1.1-negative NKT cells to transgenic BATF defines a role for activator protein-1 in the expansion and maturation of immature NKT cells in the thymus. J Immunol 178:58-66
White, Kellie J; Kiser, Philip D; Nichols, David E et al. (2006) Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter. Protein Sci 15:2411-22
Cumbay, Medhane G; Watts, Val J (2005) Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway. Biochem Pharmacol 69:1247-56
Hobbs, Stuart S; Gallo, Richard M; Riese Jr, David J (2005) Phe45 of NRG2beta is critical for the affinity of NRG2beta for ErbB4 and for potent stimulation of ErbB4 signaling by NRG2beta*. Growth Factors 23:273-83
Hobbs, Stuart S; Cameron, Elizabeth M; Hammer, Robert P et al. (2004) Five carboxyl-terminal residues of neuregulin2 are critical for stimulation of signaling by the ErbB4 receptor tyrosine kinase. Oncogene 23:883-93
Cumbay, Medhane G; Watts, Val J (2004) Novel regulatory properties of human type 9 adenylate cyclase. J Pharmacol Exp Ther 310:108-15
Hobbs, Stuart S; Coffing, Stephanie L; Le, Ann T D et al. (2002) Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation. Oncogene 21:8442-52