The goal of this training program is to prepare young investigators to perform clinically applicable and translational research in the field of trauma science. The program is based at the Burn and Shock Trauma Institute of Loyola University in Chicago, a unique, highly collaborative research environment that includes more than 50 people, including seven principle investigators, four additional scientific faculty, five clinical specialists in trauma and critical care, eight post-doctoral fellows (both MDs and Ph.D.s), nine graduate students, two research nurses, six research technicians, and two support staff. The program solicits applications from resident physicians and post-doctoral Ph.D.s to enter a two-year period of intense research training in traumatology. The program, which has been in place since 2000, currently accepts one new trainee each year, and a goal for the next cycle is to expand the program to include the appointment of two new trainees each year. A specific plan for the recruitment of underrepresented minorities, which includes our efforts at local and national levels and a comprehensive plan to promote educational and mentorship opportunities for young minority students at school, undergraduate and medical school levels are provided. Trainees are allowed to select from among seven different principal investigators who are each experienced mentors in trauma-related research, including 1) myelopoietic alterations after injury, 2) alcohol induced immune changes following burn and sepsis, 3) immune regulation in aging, 4) wound healing and vascular repair, 5) alcohol induced changes in bone mineral metabolism and fracture healing and 6) ubiquitin- proteosome system in trauma biology. The training plan emphasizes a close working relationship between each trainee and their mentor, and includes laboratory research, seminars, journal clubs, training in grant writing, and didactic coursework in both statistics and research bioethics. Written research proposals, formal research presentations, and semi-annual evaluations are required of all trainees. To develop an appreciation for clinical problems, Ph.D. trainees participate in selected clinical conferences and attend rounds on the Trauma and Burn Services during defined periods. Our long-term goal is to increase the number of clinicians and Ph.D. scientists who are qualified and motivated to work together to address fundamental questions in transitional trauma research.

Public Health Relevance

Loss of life and productivity due to trauma is one of the major societal problems at the national level. Understanding the biology of traumatology to improve the standard of care of the critically injured patients is an essential element in our battle to reduce the impact of trauma on society and thus improve national productivity. Training future clinicians who will take care of trauma patients in the science of trauma biology /will lead to new interventional and therapeutic strategies to the critically injured patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008750-15
Application #
8703117
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Somers, Scott D
Project Start
2000-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Loyola University Chicago
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Maywood
State
IL
Country
United States
Zip Code
60153
Tripathi, Abhishek; Gaponenko, Vadim; Majetschak, Matthias (2016) Commercially available antibodies directed against α-adrenergic receptor subtypes and other G protein-coupled receptors with acceptable selectivity in flow cytometry experiments. Naunyn Schmiedebergs Arch Pharmacol 389:243-8
Kothari, Anai N; Halandras, Pegge M; Drescher, Max et al. (2016) Transient postoperative atrial fibrillation after abdominal aortic aneurysm repair increases mortality risk. J Vasc Surg 63:1240-7
Nassoiy, Sean P; Blackwell, Robert H; Kothari, Anai N et al. (2016) New onset postoperative atrial fibrillation predicts long-term cardiovascular events after gastrectomy. Am J Surg 211:559-64
Evans, Ann E; Tripathi, Abhishek; LaPorte, Heather M et al. (2016) New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle. Int J Mol Sci 17:
Blackwell, Robert H; Barton, Gregory J; Kothari, Anai N et al. (2016) Early Intervention during Acute Stone Admissions: Revealing ""The Weekend Effect"" in Urological Practice. J Urol 196:124-30
Thalji, Samih Z; Kothari, Anai N; Kuo, Paul C et al. (2016) Acute Kidney Injury in Burn Patients: Clinically Significant Over the Initial Hospitalization and 1 Year After Injury: An Original Retrospective Cohort Study. Ann Surg :
Brownlee, Sarah A; Blackwell, Robert H; Blanco, Barbara A et al. (2016) Impact of Post-Hospital Syndrome on Outcomes Following Elective, Ambulatory Surgery. Ann Surg :
Chang, Victor; Blackwell, Robert H; Yau, Ryan M et al. (2016) Variable surgical outcomes after hospital consolidation: Implications for local health care delivery. Surgery 160:1155-1161
Carter, Stewart R; Chen, Michael M; Palmer, Jessica L et al. (2016) Neutrophil Accumulation in the Small Intestine Contributes to Local Tissue Destruction Following Combined Radiation and Burn Injury. J Burn Care Res 37:97-105
Kothari, Anai N; Yau, Ryan M; Blackwell, Robert H et al. (2016) Inpatient Rehabilitation after Liver Transplantation Decreases Risk and Severity of 30-Day Readmissions. J Am Coll Surg 223:164-171.e2

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