The goal of this training grant proposal is to prepare predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty consists of an outstanding, internationally recognized group of investigators in the Depts. of Chemistry and Biochemistry;Molecular, Cellular, Developmental Biology;Chemical and Biological Engineering;and Physics, who study basic cell regulatory mechanisms through discovery and characterization of key components in signaling pathways, transfer of biological information through protein conformational changes and posttranslational modifications, computational analysis and mathematical modeling of complex biological pathways, and formulation of new therapeutic strategies for human diseases. The program provides students with rigorous training in experimental design, scientific technique, and data evaluation, exposure to a wide range of scientific disciplines, training in classroom teaching, opportunities for scientific presentation, and training in standards for professional conduct. In Year 1, students take coursework and teaching duties in their home departments, and carry out laboratory rotations. At the end of Year 1, students choose a thesis advisor and elect to join this training program. In Year 2, students begin research and take elective coursework tailored to this program. Written and oral qualifying exams including the defense of a dissertation research proposal are required to advance to Ph.D. candidacy. In Years 3 and beyond, students obtain high caliber research training through the thesis project, with progress monitored yearly until graduation. Students add to their breadth and knowledge by participating in program symposia, supergroups, journal clubs, and seminars, and by presenting their work before large audiences. Students complete the program by defending a doctoral dissertation and receive a Ph.D. degree in Biochemistry or MCDB. Most students finish within 6 years of matriculation, and go on to postdoctoral training and careers in academia, research institutes, or pharmaceutical/biotechnology companies.
The goal of this training grant is to prepare the next generation of scientists who will conduct high quality research and make new discoveries in biomedical sciences. The research focus of students who train in our program is to understand fundamental mechanisms in signaling and cellular regulation, an area which is key to the discovery of new therapeutic treatments for human diseases such as cancer, diabetes, inflammation, heart disease, immunological and neurological disorders, and birth defects, and forms a foundation for modern research in biology and medicine.
|Ebmeier, Christopher C; Erickson, Benjamin; Allen, Benjamin L et al. (2017) Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications. Cell Rep 20:1173-1186|
|Porter, Ely B; Polaski, Jacob T; Morck, Makenna M et al. (2017) Recurrent RNA motifs as scaffolds for genetically encodable small-molecule biosensors. Nat Chem Biol 13:295-301|
|McQuate, Sarah E; Young, Alexandra M; Silva-Herzog, Eugenia et al. (2017) Long-term live-cell imaging reveals new roles for Salmonella effector proteins SseG and SteA. Cell Microbiol 19:|
|Zabinsky, Rebecca A; Weum, Brett M; Cui, Mingxue et al. (2017) RNA Binding Protein Vigilin Collaborates with miRNAs To Regulate Gene Expression for Caenorhabditis elegans Larval Development. G3 (Bethesda) 7:2511-2518|
|Burke, Russell T; Marcus, Joshua M; Orth, James D (2017) Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells. Oncotarget 8:39460-39475|
|Warner, Lisa R; Gatzeva-Topalova, Petia Z; Doerner, Pamela A et al. (2017) Flexibility in the Periplasmic Domain of BamA Is Important for Function. Structure 25:94-106|
|Pugach, Emily K; Blenck, Christa L; Dragavon, Joseph M et al. (2016) Estrogen receptor profiling and activity in cardiac myocytes. Mol Cell Endocrinol 431:62-70|
|Liu, Wallace H; Roemer, Sarah C; Zhou, Yeyun et al. (2016) The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. Elife 5:|
|Flynn, Aaron D; Yin, Hang (2016) Lipid-Targeting Peptide Probes for Extracellular Vesicles. J Cell Physiol 231:2327-32|
|Wang, Li; Siegenthaler, Julie A; Dowell, Robin D et al. (2016) Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science 351:613-7|
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