The goal of this training grant proposal is to prepare predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty consists of an outstanding, internationally recognized group of investigators in the Depts. of Chemistry and Biochemistry;Molecular, Cellular, Developmental Biology;Chemical and Biological Engineering;and Physics, who study basic cell regulatory mechanisms through discovery and characterization of key components in signaling pathways, transfer of biological information through protein conformational changes and posttranslational modifications, computational analysis and mathematical modeling of complex biological pathways, and formulation of new therapeutic strategies for human diseases. The program provides students with rigorous training in experimental design, scientific technique, and data evaluation, exposure to a wide range of scientific disciplines, training in classroom teaching, opportunities for scientific presentation, and training in standards for professional conduct. In Year 1, students take coursework and teaching duties in their home departments, and carry out laboratory rotations. At the end of Year 1, students choose a thesis advisor and elect to join this training program. In Year 2, students begin research and take elective coursework tailored to this program. Written and oral qualifying exams including the defense of a dissertation research proposal are required to advance to Ph.D. candidacy. In Years 3 and beyond, students obtain high caliber research training through the thesis project, with progress monitored yearly until graduation. Students add to their breadth and knowledge by participating in program symposia, supergroups, journal clubs, and seminars, and by presenting their work before large audiences. Students complete the program by defending a doctoral dissertation and receive a Ph.D. degree in Biochemistry or MCDB. Most students finish within 6 years of matriculation, and go on to postdoctoral training and careers in academia, research institutes, or pharmaceutical/biotechnology companies.

Public Health Relevance

The goal of this training grant is to prepare the next generation of scientists who will conduct high quality research and make new discoveries in biomedical sciences. The research focus of students who train in our program is to understand fundamental mechanisms in signaling and cellular regulation, an area which is key to the discovery of new therapeutic treatments for human diseases such as cancer, diabetes, inflammation, heart disease, immunological and neurological disorders, and birth defects, and forms a foundation for modern research in biology and medicine.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Gindhart, Joseph G
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University of Colorado at Boulder
Schools of Arts and Sciences
United States
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O'Hara, Samantha D; Garcea, Robert L (2016) Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection. MBio 7:
Bennett, Christopher G; Riemondy, Kent; Chapnick, Douglas A et al. (2016) Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration. Nucleic Acids Res 44:3788-800
Blenck, Christa L; Harvey, Pamela A; Reckelhoff, Jane F et al. (2016) The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease. Circ Res 118:1294-312
Pugach, Emily K; Blenck, Christa L; Dragavon, Joseph M et al. (2016) Estrogen receptor profiling and activity in cardiac myocytes. Mol Cell Endocrinol 431:62-70
Flynn, Aaron D; Yin, Hang (2016) Lipid-Targeting Peptide Probes for Extracellular Vesicles. J Cell Physiol 231:2327-32
Yin, Hang; Flynn, Aaron D (2016) Drugging Membrane Protein Interactions. Annu Rev Biomed Eng 18:51-76
Wang, Li; Siegenthaler, Julie A; Dowell, Robin D et al. (2016) Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science 351:613-7
McQuate, Sarah E; Young, Alexandra M; Silva-Herzog, Eugenia et al. (2016) Long-term live-cell imaging reveals new roles for Salmonella effector proteins SseG and SteA. Cell Microbiol :
Lerner, Eitan; Chung, SangYoon; Allen, Benjamin L et al. (2016) Backtracked and paused transcription initiation intermediate of Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A 113:E6562-E6571
de Jesus, Armando J; White, Ormacinda R; Flynn, Aaron D et al. (2016) Determinants of Curvature-Sensing Behavior for MARCKS-Fragment Peptides. Biophys J 110:1980-92

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