The redesigned focus of this training grant is described in the title, """"""""Postdoctoral Training Program in Trauma and Hemorrhagic Shock,"""""""" and has led to 148 publications in peer-reviewed journals, as well as another 60 published abstracts in local, regional and national meetings. This training program is targeted at the postdoctoral level. The goal of the Trauma Research Training Program is to prepare researchers to become academically competitive, clinical scientists who can design and execute laboratory models to test clinically-relevant hypotheses, collaborate with other scientists to enhance the basic understanding of the problem they are studying, and clinically translate this information. To accomplish these goals, our program selects fellows each calendar year for two-year positions. The program plans to recruit postdoctoral candidates who are interested in pursuing an academic career in trauma-related research. At the end of the two years of training, each fellow is able to: 1) critically analyze available published data;2) formulate a focused hypothesis;3) design and perform necessary experiments to test the hypothesis;4) analyze results to formulate appropriate conclusions and modify experimental strategies;5) effectively present the results of their research both orally and in writing (by manuscript);and 6) prepare a competitive research proposal. Ten of the 11 fellows that completed their training have pursued academic careers and are currently in faculty positions;five of these fellows have been awarded independent funding. Since its creation in 2001, this T-32 training program has evolved, and recently new elements have been added to advance and focus our training efforts. In the current funding cycle, the laboratory focus has evolved into studying the global theme of trauma with particular focus on traumatic brain injury, resuscitation, and organ injury/dysfunction. Dr. John Holcomb remains the Program Director of the training program and he is assisted by Drs. Rosemary Kozar and Charles Cox-two clinical scientists with significant translational research experience. The leadership receives guidance from an Executive Committee and External Reviewers. Each trainee has a Primary and Junior Mentor who are responsible for ensuring the research fellow can :1) formulate a focused research proposal, 2) access laboratory supplies, equipment, and technical instructions, 3) analyze the results, draw conclusions, and revise strategies, and 4) organize both oral and written presentations. Additionally, the fellow complete required and optional didactic coursework, attend weekly and monthly meetings, and participate in seminars and symposia with collaborators. A list of Resource Faculty members are available to assist in project execution. Taken together, this comprehensive approach ensures that a well-rounded, diverse faculty will lead these young scientists along the path to academic independence and significant contributions for injured patients.

Public Health Relevance

Trauma is a serious healthcare problem. It is the leading cause of death in people from 1-44 years and because it is a disease of young people, injury is the leading cause of life years lost. Funding our trauma research training program will enable future clinical scientist to increase basic and clinical understanding of trauma-related illness, improving the outcome of injured patients.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZGM1-BRT-5 (PD))
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Somers, Scott D
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University of Texas Health Science Center Houston
Schools of Medicine
United States
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Scerbo, Michelle H; Kaplan, Heidi B; Dua, Anahita et al. (2016) Beyond Blood Culture and Gram Stain Analysis: A Review of Molecular Techniques for the Early Detection of Bacteremia in Surgical Patients. Surg Infect (Larchmt) 17:294-302
Chang, Ronald; Cardenas, Jessica C; Wade, Charles E et al. (2016) Advances in the understanding of trauma-induced coagulopathy. Blood 128:1043-9
Scerbo, Michelle H; Mumm, Jacob P; Gates, Keith et al. (2016) Safety and Appropriateness of Tourniquets in 105 Civilians. Prehosp Emerg Care 20:712-722
Chang, Ronald; Folkerson, Lindley E; Sloan, Duncan et al. (2016) Early plasma transfusion is associated with improved survival after isolated traumatic brain injury in patients with multifocal intracranial hemorrhage. Surgery :
Cox Jr, Charles S; Hetz, Robert A; Liao, George P et al. (2016) Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells. Stem Cells :
Chang, Ronald; Holcomb, John B (2016) Choice of Fluid Therapy in the Initial Management of Sepsis, Severe Sepsis, and Septic Shock. Shock 46:17-26
Stensballe, Jakob; Holcomb, John B (2015) Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage-But did they in fact test the effect of hemostatic resuscitation? J Trauma Acute Care Surg 78:1237
Liao, George P; Harting, Matthew T; Hetz, Robert A et al. (2015) Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children. Pediatr Crit Care Med 16:245-55
Scerbo, Michelle; Radhakrishnan, Hari; Cotton, Bryan et al. (2014) Prehospital triage of trauma patients using the Random Forest computer algorithm. J Surg Res 187:371-6
Liao, George P; Olson, Scott D; Kota, Daniel J et al. (2014) Far-red tracer analysis of traumatic cerebrovascular permeability. J Surg Res 190:628-33

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