The redesigned focus of this training grant is described in the title, """"""""Postdoctoral Training Program in Trauma and Hemorrhagic Shock,"""""""" and has led to 148 publications in peer-reviewed journals, as well as another 60 published abstracts in local, regional and national meetings. This training program is targeted at the postdoctoral level. The goal of the Trauma Research Training Program is to prepare researchers to become academically competitive, clinical scientists who can design and execute laboratory models to test clinically-relevant hypotheses, collaborate with other scientists to enhance the basic understanding of the problem they are studying, and clinically translate this information. To accomplish these goals, our program selects fellows each calendar year for two-year positions. The program plans to recruit postdoctoral candidates who are interested in pursuing an academic career in trauma-related research. At the end of the two years of training, each fellow is able to: 1) critically analyze available published data;2) formulate a focused hypothesis;3) design and perform necessary experiments to test the hypothesis;4) analyze results to formulate appropriate conclusions and modify experimental strategies;5) effectively present the results of their research both orally and in writing (by manuscript);and 6) prepare a competitive research proposal. Ten of the 11 fellows that completed their training have pursued academic careers and are currently in faculty positions;five of these fellows have been awarded independent funding. Since its creation in 2001, this T-32 training program has evolved, and recently new elements have been added to advance and focus our training efforts. In the current funding cycle, the laboratory focus has evolved into studying the global theme of trauma with particular focus on traumatic brain injury, resuscitation, and organ injury/dysfunction. Dr. John Holcomb remains the Program Director of the training program and he is assisted by Drs. Rosemary Kozar and Charles Cox-two clinical scientists with significant translational research experience. The leadership receives guidance from an Executive Committee and External Reviewers. Each trainee has a Primary and Junior Mentor who are responsible for ensuring the research fellow can :1) formulate a focused research proposal, 2) access laboratory supplies, equipment, and technical instructions, 3) analyze the results, draw conclusions, and revise strategies, and 4) organize both oral and written presentations. Additionally, the fellow complete required and optional didactic coursework, attend weekly and monthly meetings, and participate in seminars and symposia with collaborators. A list of Resource Faculty members are available to assist in project execution. Taken together, this comprehensive approach ensures that a well-rounded, diverse faculty will lead these young scientists along the path to academic independence and significant contributions for injured patients.

Public Health Relevance

Trauma is a serious healthcare problem. It is the leading cause of death in people from 1-44 years and because it is a disease of young people, injury is the leading cause of life years lost. Funding our trauma research training program will enable future clinical scientist to increase basic and clinical understanding of trauma-related illness, improving the outcome of injured patients.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZGM1-BRT-5 (PD))
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Somers, Scott D
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University of Texas Health Science Center Houston
Schools of Medicine
United States
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George, M J; Burchfield, J; MacFarlane, B et al. (2017) Multiplate and TEG platelet mapping in a population of severely injured trauma patients. Transfus Med :
Chang, Ronald; Fox, Erin E; Greene, Thomas J et al. (2017) Multicenter retrospective study of noncompressible torso hemorrhage: Anatomic locations of bleeding and comparison of endovascular versus open approach. J Trauma Acute Care Surg 83:11-18
Chang, Ronald; Holcomb, John B (2017) Implementation of Massive Transfusion Protocols in the United States: The Relationship Between Evidence and Practice. Anesth Analg 124:9-11
Oyeniyi, Blessing T; Fox, Erin E; Scerbo, Michelle et al. (2017) Trends in 1029 trauma deaths at a level 1 trauma center: Impact of a bleeding control bundle of care. Injury 48:5-12
Cox Jr, Charles S; Hetz, Robert A; Liao, George P et al. (2017) Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells. Stem Cells 35:1065-1079
Chang, Ronald; Eastridge, Brian J; Holcomb, John B (2017) Remote Damage Control Resuscitation in Austere Environments. Wilderness Environ Med 28:S124-S134
George, Mitchell J; Aroom, Kevin R; Skibber, Max A et al. (2017) A Useful Device to Measure Kinetics of Platelet Contraction. ASAIO J :
Chang, Ronald; Holcomb, John B (2017) Optimal Fluid Therapy for Traumatic Hemorrhagic Shock. Crit Care Clin 33:15-36
Chang, Ronald; Fox, Erin E; Greene, Thomas J et al. (2017) Abnormalities of laboratory coagulation tests versus clinically evident coagulopathic bleeding: results from the prehospital resuscitation on helicopters study (PROHS). Surgery :
Chang, Ronald; Scerbo, Michelle H; Schmitt, Karl M et al. (2017) Early chemoprophylaxis is associated with decreased venous thromboembolism risk without concomitant increase in intraspinal hematoma expansion after traumatic spinal cord injury. J Trauma Acute Care Surg 83:1088-1094

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