This training grant proposal is entitled """"""""The cellular and molecular foundations of biomedical sciences"""""""". It is a renewal of a successful program started six years ago and seeks to train graduate students in the broad fundamentals of biomedical sciences to provide them with the tools to understand important problems in modern biology and health. This is accomplished initially through a two semester Core course covering Genetics, Genomics and Bioinformatics, Eukaryotic molecular biology, Molecular biophysics, Protein structure and function, and Cell biology. Students follow this with electives in specific fields of their interest. This interdepartmental program is based in the Department of Biological Sciences, but has been expanded to include established faculty from Columbia's College of Physicians and Surgeons. Students undertake rotations in up to three laboratories and can do their thesis work in any of the 47 faculty in the program, roughly half of which are on the Medical School campus. This has provided expanded opportunities for training of the students in outstanding laboratories and has fostered collaboration between faculty and students at Columbia's Medical School and main campuses. The faculty members work in a broad range of fields including structural biology, molecular biology, genetics, bioinformatics and systems biology, developmental biology and neurobiology. Experimental systems are also broad including bacteria, yeast, drosophila, C. elegans, frogs and mice. Human tissue culture systems are also utilized and most systems consider problems relevant to human health and physiology. Twelve graduate student traineeships are requested per year to support six students for two years each, usually in their third and fourth years. This will fund 19% of our current training grant eligible student pool of 63. The best students in our program will be chosen to be funded by this grant. This will be determined by their performance in the Core and other courses, recommendations from their rotation and thesis sponsors, and a short research proposal reviewed by the grant's steering committee. The qualifications of the faculty and the research facilities at Columbia are outstanding and provides a superb training environment for the students.

Public Health Relevance

The training of the next generation of biomedical scientists is essential to continued excellence of research in the U.S. and advances in understanding, controlling and curing human disease. Laboratories in the program address specific basic problems in biomedical sciences, many with direct applications to human disease.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Other Domestic Higher Education
New York
United States
Zip Code
Smith, Michael J; Bryant, Eric E; Rothstein, Rodney (2018) Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint. Genes Dev 32:1242-1251
Conlon, Erin G; Fagegaltier, Delphine; Agius, Phaedra et al. (2018) Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism. Elife 7:
Lin, Yu-Cheng; Cornell, William Cole; Jo, Jeanyoung et al. (2018) The Pseudomonas aeruginosa Complement of Lactate Dehydrogenases Enables Use of d- and l-Lactate and Metabolic Cross-Feeding. MBio 9:
Yurko, Nathan M; Manley, James L (2018) The RNA polymerase II CTD ""orphan"" residues: Emerging insights into the functions of Tyr-1, Thr-4, and Ser-7. Transcription 9:30-40
Tomljanovic, Zeljko; Patel, Mitesh; Shin, William et al. (2018) ZCCHC17 is a master regulator of synaptic gene expression in Alzheimer's disease. Bioinformatics 34:367-371
Rajbhandari, Presha; Lopez, Gonzalo; Capdevila, Claudia et al. (2018) Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. Cancer Discov 8:582-599
Burn, Sally F; Washkowitz, Andrew J; Gavrilov, Svetlana et al. (2018) Postimplantation Mga expression and embryonic lethality of two gene-trap alleles. Gene Expr Patterns 27:31-35
Reilein, Amy; Melamed, David; Park, Karen Sophia et al. (2017) Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling. Nat Cell Biol 19:433-444
Conlon, Erin G; Manley, James L (2017) RNA-binding proteins in neurodegeneration: mechanisms in aggregate. Genes Dev 31:1509-1528
Leyva-Díaz, Eduardo; Stefanakis, Nikolaos; Carrera, Inés et al. (2017) Silencing of Repetitive DNA Is Controlled by a Member of an Unusual Caenorhabditis elegans Gene Family. Genetics 207:529-545

Showing the most recent 10 out of 82 publications