This is a proposal to the Graduate Training Program in Biotechnology in support of 12 trainee positions for predoctoral students. To be effective healthcare research must be undertaken at a comprehensive integrated systems level rather than depending on the older reductionist approach. The techniques of the post-genomic era are now making this an attainable goal. This Training Program in Biomolecular Technology has been highly successful in training predoctoral students within such an environment. It provides well-coordinated multidisciplinary training of graduate students in critical areas of health-relate biotechnology research and a structure for interdisciplinary investigation that integrates basic biological science, engineering and quantitative disciplines as well as industrial experiences. Discipline oriented training is provided by relevant graduate groups. This Program has provided direct support for 22 second to fourth-year graduate students and indirect support for 18 additional trainees. The tools and framework for interdisciplinary research are provided to all in the Program who complete the Designated Emphasis in Biotechnology (DEB). The over 200 strong DEB provides multidisciplinary biotechnology concentration over and above the discipline-oriented requirements of graduate groups. The Program includes proactive and interactive research training, specialized multidisciplinary courses, a student run research chalk talk, a seminar series with leading extramural researchers in the field of biotechnology, research meetings, an annual retreat and other efforts aimed at developing integrated projects on campus and with affiliates. The heart of this Program is the research training that occurs in the university and the internship experience at industrial trainers'laboratories during the student's second to fourth years. The Retreat serves as a forum for discussion of research, ideas and proposals and provides opportunities to develop internship and collaborative research connections with industry. An Executive Committee assists the director in administering the Program while a subcommittee of Academic Senate members determines course content. Trainers and trainees are evaluated annually by the Committee to ensure the most effective training program. The quality is assessed from publication records, research grant support, record of student training, emphasis on biomolecular technology projects within a quantitative context, and multidisciplinary collaboration with other laboratories. The Program is designed to recruit and support trainees who show exceptional promise and to immerse them in an environment that will prepare them to be independent scientists who will advance the field of US health research.

Public Health Relevance

At the University of California at Davis, we view healthcare as encompassing disease prevention and health optimization not just pathology focused research. To that end we have devised a graduate training program whose focus is at the juncture of in-depth specialist instruction in the healthcare research arena with a cross disciplinary perspective to complement students training in problem identification and solving within their own fields. Our aim is to nurture exceptional students and provide them with a training experience that will prepare them to be world-class scientists who will advance the foundation of US healthcare research.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008799-12
Application #
8501498
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gerratana, Barbara
Project Start
2000-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
12
Fiscal Year
2013
Total Cost
$215,271
Indirect Cost
$12,735
Name
University of California Davis
Department
Zoology
Type
Schools of Earth Sciences/Natur
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Krishnan, Sridevi; Agrawal, Karan; Tryon, Rebecca R et al. (2018) Structural equation modeling of food craving across the menstrual cycle using behavioral, neuroendocrine, and metabolic factors. Physiol Behav 195:28-36
Westreich, Samuel T; Treiber, Michelle L; Mills, David A et al. (2018) SAMSA2: a standalone metatranscriptome analysis pipeline. BMC Bioinformatics 19:175
Pecic, Stevan; Zeki, Amir A; Xu, Xiaoming et al. (2018) Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability. Prostaglandins Other Lipid Mediat 136:90-95
Baek, Han Bit; Lombard, Alan P; Libertini, Stephen J et al. (2018) XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. Oncotarget 9:34567-34581
Agrawal, Karan; Sivamani, Raja K; Newman, John W (2018) Noninvasive profiling of sweat-derived lipid mediators for cutaneous research. Skin Res Technol :
Lewis, Daniel D; Chavez, Michael; Chiu, Kwan Lun et al. (2018) Reconfigurable Analog Signal Processing by Living Cells. ACS Synth Biol 7:107-120
Agrawal, Karan; Bosviel, Rémy; Piccolo, Brian D et al. (2018) Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males. Prostaglandins Other Lipid Mediat 137:1-8
Agrawal, Karan; Waller, Justin D; Pedersen, Theresa L et al. (2018) Effects of stimulation technique, anatomical region, and time on human sweat lipid mediator profiles. Prostaglandins Other Lipid Mediat 134:84-92
Vaziri, Sana; Koehl, Patrice; Aviran, Sharon (2018) Extracting information from RNA SHAPE data: Kalman filtering approach. PLoS One 13:e0207029
Karav, Sercan; Cohen, Joshua L; Barile, Daniela et al. (2017) Recent advances in immobilization strategies for glycosidases. Biotechnol Prog 33:104-112

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