This is a competitive renewal for the post-doctoral multidisciplinary basic science Trauma and Inflammation Research Training Program at the Department of Surgery, The Alpert Medical School of Brown University. The Program's goal is to identify, recruit, and train the next generation of Trauma Scientists with particular emphasis on retaining MDs in academic trauma medicine careers. Formal training in research involves the acquisition of the technical, intellectual, philosophical and ethical habits and abilities of the scientist. Development of these traits in the trainees is the most important goal of the Program. Faculty from the Departments of Surgery;Engineering;Neurosurgery;Medicine;Molecular Microbiology and Immunology;Molecular Biology, Cell Biology and Biochemistry;and Pathology at Brown University, and their respective laboratories, afford trainees ideal opportunities to select areas for research. The Level 1 Trauma and Burn Centers at Rhode Island Hospital provide clinical correlates for basic research. The Program is led by a Director who is advised and assisted by an Executive Committee in the selection, guidance and evaluation of trainees. A Co-Director assists the Director in the day-to-day running of the program and stands-in in his absence. An Extramural Advisors Panel assures the excellence of the Training Program. Two trainees per year are selected nationally, among residents in any branch of surgery and recently graduated PhDs. Major emphasis is placed on recruiting candidates from under-represented minorities. The Training Program lasts two years. The curriculum includes required courses in Biostatistics, Responsible Conduct of Research, and Scientific Writing, as well as elective courses tailored to the specific needs of the trainees. A faculty mentor and an Advisory Group (modeled after a PhD thesis committee and including an experienced trauma care clinician) provide direction, support and supervision, as well as a clinical outlook.on the research project. Trainees will have no clinical responsibilities during the training period. This comprehensive program provides the trainee with the technical and intellectual tools necessary to pursue an academic career in research areas related to trauma and inflammation. Relevance: Trauma continues to be a leading cause of death and disability in the USA. The Program aims to train surgical residents or recently graduated PhDs as the next generation of Trauma Scientists, capable of bringing advances in the understanding of the underlying mechanisms of "trauma disease" to the bedside and improve the outcome of trauma victims

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM065085-10
Application #
8493804
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Somers, Scott D
Project Start
2002-04-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$69,011
Indirect Cost
$8,571
Name
Rhode Island Hospital
Department
Type
DUNS #
075710996
City
Providence
State
RI
Country
United States
Zip Code
02903
Hutchins, Noelle A; Unsinger, Jacqueline; Hotchkiss, Richard S et al. (2014) The new normal: immunomodulatory agents against sepsis immune suppression. Trends Mol Med 20:224-33
Ayala, Alfred; Elphick, Gwendolyn F; Kim, Ye Sul et al. (2014) Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency. J Innate Immun 6:325-38
Brancato, Samielle K; Thomay, Alan A; Daley, Jean M et al. (2013) Toll-like receptor 4 signaling regulates the acute local inflammatory response to injury and the fibrosis/neovascularization of sterile wounds. Wound Repair Regen 21:624-33
Brancato, Samielle K; Albina, Jorge E (2011) Wound macrophages as key regulators of repair: origin, phenotype, and function. Am J Pathol 178:19-25
Daley, Jean M; Brancato, Samielle K; Thomay, Alan A et al. (2010) The phenotype of murine wound macrophages. J Leukoc Biol 87:59-67
Neves, Susana R; Iyengar, Ravi (2009) Models of spatially restricted biochemical reaction systems. J Biol Chem 284:5445-9
Elphick, Gwendolyn F; Sarangi, Pranita P; Hyun, Young-Min et al. (2009) Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood 113:4078-85
Huang, Xin; Venet, Fabienne; Wang, Yvonne L et al. (2009) PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc Natl Acad Sci U S A 106:6303-8
Daley, Jean M; Thomay, Alan A; Connolly, Michael D et al. (2008) Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J Leukoc Biol 83:64-70
Ayala, Alfred; Perl, Mario; Venet, Fabienne et al. (2008) Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets. Curr Pharm Des 14:1853-9

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