This proposal requests continuing support for a Chemistry-Biology Interface (CBI) Training Program at Vanderbilt University. Thirty four faculty preceptors from five departments in the College of Arts and Sciences and in the School of Medicine will serve as mentors for the Program. Significant biological training will be provided to students receiving in-depth training in synthetic/mechanistic chemistry and significant training in synthetic/mechanistic chemistry will be provided to students receiving in-depth training in the biological sciences. Highlights of the training program include a chemical biology curriculum, elective courses for specialized training, research and professional development workshops, an interactive seminar series in chemical biology, an annual research symposium, peer teaching and an in-depth laboratory research experience. Students will be well-grounded in a core discipline and sufficiently well-trained in complementary fields to allow them to work effectively in an interdisciplinary environment. Support for ten trainees is requested. Trainees will obtain Ph.D. degrees working with preceptors in the Departments of Biochemistry (9 preceptors), Chemistry (11 preceptors), Microbiology and Immunology (2 preceptor), Molecular Physiology and Biophysics (3 preceptor) and Pharmacology (9 preceptors).

Public Health Relevance

The trainees participating in the CBI training program are engaged in a number of NIH-supported projects that employ techniques, understanding and tools of chemistry to study a variety of biomedical problems with relevance to the study of disease mechanism and therapeutic agent development.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Fabian, Miles
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Vanderbilt University Medical Center
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Reid, Kemar R; McBride, James R; Freymeyer, Nathaniel J et al. (2018) Chemical Structure, Ensemble and Single-Particle Spectroscopy of Thick-Shell InP-ZnSe Quantum Dots. Nano Lett 18:709-716
Earl, David C; Ferrell Jr, P Brent; Leelatian, Nalin et al. (2018) Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Nat Commun 9:39
Craft, Kelly M; Gaddy, Jennifer A; Townsend, Steven D (2018) Human Milk Oligosaccharides (HMOs) Sensitize Group B Streptococcus to Clindamycin, Erythromycin, Gentamicin, and Minocycline on a Strain Specific Basis. ACS Chem Biol 13:2020-2026
Covington, Brett C; Spraggins, Jeffrey M; Ynigez-Gutierrez, Audrey E et al. (2018) Response of Hypogean Actinobacterial Genera Secondary Metabolism to Chemical and Biological Stimuli. Appl Environ Microbiol :
Shockley, Erin M; Vrugt, Jasper A; Lopez, Carlos F (2018) PyDREAM: high-dimensional parameter inference for biological models in python. Bioinformatics 34:695-697
Wauchope, Orrette R; Mitchener, Michelle M; Beavers, William N et al. (2018) Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA. Nucleic Acids Res 46:3458-3467
Thal, Lucas B; Tomlinson, Ian D; Quinlan, Meagan A et al. (2018) Single Quantum Dot Imaging Reveals PKC?-Dependent Alterations in Membrane Diffusion and Clustering of an Attention-Deficit Hyperactivity Disorder/Autism/Bipolar Disorder-Associated Dopamine Transporter Variant. ACS Chem Neurosci :
Shaw, Subrata; Bian, Zhiguo; Zhao, Bin et al. (2018) Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design. J Med Chem 61:2410-2421
Starbird, C A; Tomasiak, Thomas M; Singh, Prashant K et al. (2018) New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement. J Struct Biol 202:100-104
Galligan, James J; Wepy, James A; Streeter, Matthew D et al. (2018) Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks. Proc Natl Acad Sci U S A 115:9228-9233

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