This proposal requests continuing support for a Chemistry-Biology Interface (CBI) Training Program at Vanderbilt University. Thirty four faculty preceptors from five departments in the College of Arts and Sciences and in the School of Medicine will serve as mentors for the Program. Significant biological training will be provided to students receiving in-depth training in synthetic/mechanistic chemistry and significant training in synthetic/mechanistic chemistry will be provided to students receiving in-depth training in the biological sciences. Highlights of the training program include a chemical biology curriculum, elective courses for specialized training, research and professional development workshops, an interactive seminar series in chemical biology, an annual research symposium, peer teaching and an in-depth laboratory research experience. Students will be well-grounded in a core discipline and sufficiently well-trained in complementary fields to allow them to work effectively in an interdisciplinary environment. Support for ten trainees is requested. Trainees will obtain Ph.D. degrees working with preceptors in the Departments of Biochemistry (9 preceptors), Chemistry (11 preceptors), Microbiology and Immunology (2 preceptor), Molecular Physiology and Biophysics (3 preceptor) and Pharmacology (9 preceptors).

Public Health Relevance

The trainees participating in the CBI training program are engaged in a number of NIH-supported projects that employ techniques, understanding and tools of chemistry to study a variety of biomedical problems with relevance to the study of disease mechanism and therapeutic agent development.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Fabian, Miles
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Schools of Medicine
United States
Zip Code
DeGuire, Sean M; Earl, David C; Du, Yu et al. (2015) Fluorescent probes of the apoptolidins and their utility in cellular localization studies. Angew Chem Int Ed Engl 54:961-4
May, Jody C; Goodwin, Cody R; Lareau, Nichole M et al. (2014) Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer. Anal Chem 86:2107-16
Edwards, Sarah J; Moth, Christopher W; Kim, Sunghoon et al. (2014) Automated structure refinement for a protein heterodimer complex using limited EPR spectroscopic data and a rigid-body docking algorithm: a three-dimensional model for an ankyrin-CDB3 complex. J Phys Chem B 118:4717-26
Olmsted, Ian R; Hassanein, Mohamed; Kussrow, Amanda et al. (2014) Toward rapid, high-sensitivity, volume-constrained biomarker quantification and validation using backscattering interferometry. Anal Chem 86:7566-74
Allison, Brittany; Combs, Steven; DeLuca, Sam et al. (2014) Computational design of protein-small molecule interfaces. J Struct Biol 185:193-202
Berry, Cynthia B; Bubser, Michael; Jones, Carrie K et al. (2014) Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity. ACS Med Chem Lett 5:1060-4
Manna, Joseph D; Wepy, James A; Hsu, Ku-Lung et al. (2014) Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. J Biol Chem 289:33741-53
Moore, Jessica L; Caprioli, Richard M; Skaar, Eric P (2014) Advanced mass spectrometry technologies for the study of microbial pathogenesis. Curr Opin Microbiol 19:45-51
Hendricks, Nathan G; Lareau, Nichole M; Stow, Sarah M et al. (2014) Bond-specific dissociation following excitation energy transfer for distance constraint determination in the gas phase. J Am Chem Soc 136:13363-70
Lima, Eduardo A; Snider, Rachel M; Reiserer, Ronald S et al. (2014) Multichamber Multipotentiostat System for Cellular Microphysiometry. Sens Actuators B Chem 204:536-543

Showing the most recent 10 out of 42 publications