The mission of the Mayo M.D.-Ph.D. program is to train talented and enthusiastic students as physician scientists with advanced skills in both biomedical research and academic medicine. Specifically, we wish to prepare students for careers in basic, translational or clinical research studying fundamental questions whose answers will provide new insights into critical health problems. An MSTP grant for the Mayo M.D.- Ph.D. program was first awarded by NIGMS in 2003. During the first four years of support, our MST program has continued to develop and mature while maintaining all of the aspects that were praised by the Reviewers of the prior submission. The main strengths of our MST program are: (1) An enthusiastic training faculty of 75 mentors that provides extensive opportunities for cutting-edge interdisciplinary training in basic, translational, and clinical research;(2) Outstanding students, with 8 trainees supported by this grant over the past 5 years and a total of 47 trainees currently associated with the program, who are passionate about the study of fundamental biological processes of relevance to human disease;(3) A diverse pool of >150 highly competitive applicants;(4) An autonomous admissions process that enables selection of students based on their prior research experiences and excitement for biomedical research;(5) An effective underrepresented minority (URM) student recruitment and retention plan with 4 URM students who completed training during the past five years and 9 in training;(6) Integration of medical and graduate school curricula, which allows students to complete 4 required graduate courses and 3 laboratory rotations during the first two years of medical school;(7) Several programmatic features that respond to specific needs of M.D.-Ph.D. trainees, especially during the first two years of medical school training and the subsequent graduate school years;(8) Continuing institutional support for education, which enables us to fully fund our students throughout their medical and graduate training, providing exceptional flexibility in choosing mentors and thesis laboratories;(9) Exceptional research resources that are accessible to our students and profoundly enhance their educational experience;(10) A dedicated Director and Associate Director and outstanding administrative support for the program. We propose to build on these strengths and continue to train medical scientists who will be well equipped to advance the study of human diseases.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Preusch, Peter C
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Mayo Clinic, Rochester
United States
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Kashyap, Sonu; Warner, Gina M; Hartono, Stella P et al. (2016) Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension. Am J Physiol Renal Physiol 310:F372-84
Weaver, Robbyn L; Limzerwala, Jazeel F; Naylor, Ryan M et al. (2016) BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer. Elife 5:
Pratz, Keith W; Koh, Brian D; Patel, Anand G et al. (2016) Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms. Clin Cancer Res 22:3894-902
Jiménez-Almonte, José H; Wyles, Cody C; Wyles, Saranya P et al. (2016) Is Local Infiltration Analgesia Superior to Peripheral Nerve Blockade for Pain Management After THA: A Network Meta-analysis. Clin Orthop Relat Res 474:495-516
Ranatunga, Wasantha; Gakh, Oleksandr; Galeano, Belinda K et al. (2016) Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: THE SUB-COMPLEX FORMED BY THE IRON DONOR, Yfh1 PROTEIN, AND THE SCAFFOLD, Isu1 PROTEIN. J Biol Chem 291:10378-98
Yun, Seongseok; Vincelette, Nicole D; Knorr, Katherine L B et al. (2016) 4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells. Blood 127:2711-22
Patel, Anand G; Flatten, Karen S; Peterson, Kevin L et al. (2016) Immunodetection of human topoisomerase I-DNA covalent complexes. Nucleic Acids Res 44:2816-26
Naylor, Ryan M; Jeganathan, Karthik B; Cao, Xiuqi et al. (2016) Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. J Clin Invest 126:543-59
Wilton, Katelynn M; Crowson, Cynthia S; Matteson, Eric L (2016) Malignancy incidence in patients with psoriatic arthritis: a comparison cohort-based incidence study. Clin Rheumatol 35:2603-7
Howe, Charles L; LaFrance-Corey, Reghann G; Mirchia, Kanish et al. (2016) Neuroprotection mediated by inhibition of calpain during acute viral encephalitis. Sci Rep 6:28699

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