The shortage of well-trained physician scientists who conduct hands-on studies in humans, particularly in the area of clinical pharmacology, is widely acknowledged. The Clinical Pharmacology Training Program at Johns Hopkins is designed specifically to address this problem. The program is centered in the Division of Clinical Pharmacology, which is jointly a unit within the Department of Medicine and the Department of Pharmacology and Molecular Sciences, in the School of Medicine. This venue is ideal for conducting research that translates basic molecular discoveries and techniques into clinical trials. The training program takes about four years to complete and includes a core curriculum in clinical pharmacology (coursework plus research rotations) as well as matriculation in the PhD track of the Graduate Training Program in Clinical Investigation. In keeping with the collective expertise of the Division faculty, research typically focuses on some aspect of anti-infective drugs. Each trainee has a Primary Mentor who is the thesis supervisor and who oversees the clinical aspects of the research project, complemented when appropriate by a Co-mentor. Participating faculty include not only those in the Division but also a group of Co-Mentors carefully chosen to reflect ongoing or foreseeable research collaborations and important teaching associations. Although there are no clinical responsibilities in the program, fellows may complete a concurrent subspecialty fellowship, typically in Infectious Diseases. The program has the regular advice and oversight of an Advisory Board comprised of distinguished clinician-scientists and outstanding clinical pharmacology educators from within and outside of Johns Hopkins. Graduates from this comprehensive, rigorous, and nurturing program are board-eligible in Clinical Pharmacology and have the skills and knowledge to step directly into an independent career at the interface of basic and clinical pharmacology.
This is a program to train physicians in the principles and practice of Clinical Pharmacology, a branch of science that focuses on the study of drugs in humans and that brings basic lab discoveries to the clinic. In a three to four year program trainees will have rigorous in-class teaching and will conduct hands-on studies of drugs in humans.
|McAllister, Florencia; Pineda, Danielle M; Jimbo, Masaya et al. (2014) dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial. Cancer Biol Ther 15:688-98|
|McAllister, Florencia; Bailey, Jennifer M; Alsina, Janivette et al. (2014) Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell 25:621-37|
|Leyva, Francisco J; Bakshi, Rahul P; Fuchs, Edward J et al. (2013) Isoosmolar enemas demonstrate preferential gastrointestinal distribution, safety, and acceptability compared with hyperosmolar and hypoosmolar enemas as a potential delivery vehicle for rectal microbicides. AIDS Res Hum Retroviruses 29:1487-95|
|Rhim, Andrew D; Mirek, Emily T; Aiello, Nicole M et al. (2012) EMT and dissemination precede pancreatic tumor formation. Cell 148:349-61|
|Wu, Shaoguang; Rhee, Ki-Jong; Albesiano, Emilia et al. (2009) A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med 15:1016-22|
|Nyunt, Myaing M; Hendrix, Craig W; Bakshi, Rahul P et al. (2009) Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites. Am J Trop Med Hyg 80:528-35|
|Dooley, Kelly E; Tang, Tania; Golub, Jonathan E et al. (2009) Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis. Am J Trop Med Hyg 80:634-9|
|Hendrix, Craig W; Cao, Ying Jun; Fuchs, Edward J (2009) Topical microbicides to prevent HIV: clinical drug development challenges. Annu Rev Pharmacol Toxicol 49:349-75|
|Cao, Y-J; Hendrix, C W (2008) Male genital tract pharmacology: developments in quantitative methods to better understand a complex peripheral compartment. Clin Pharmacol Ther 83:401-12|
|Cao, Y-J; Mager, D E; Simonsick, E M et al. (2008) Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women. Clin Pharmacol Ther 83:422-9|
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