This is the first renewal application for the Chemistry-Biology Interface predoctoral training grant at UCBerkeley. The program provides graduate PhD students with a unique depth of training in the application of chemical principles and techniques to the investigation and modulation of biological systems. The program's goal is to encourage further integration of the fields of chemistry and biology and prepare students for a future of research at this interface. The graduate program provides: 1.) three 10-week rotations for first year students 2.) A core of didactic courses with additional courses selected based on individual student interest, 3.) Seminars, 4.) Annual retreat, 5.) Poster sessions at the end of each rotation period, 6.) Career day, 7.) Super group meetings, 8.) Aphid dissertation at the chemical biology interface, and 9.) aggressive diversity recruitment efforts. The program selects students from the matriculating pools of first year students in the 4 departments of Chemistry, Molecular and Cell Biology, Chemical engineering, and Bioengineering. Students are selected on the basis of their stated interest in chemical biology research, undergraduate scholastic performance, scores on GRE tests, recommendations from faculty at their undergraduate institutions, and previous research experience. The program has thrived during the first five years with 53 current students, 36 participating faculty, and 12 PhD alumni. Each year the pool of qualified applicants grows larger. The program is positioned to expand to keep up with demand. Annual support for 12 first-year students during their rotation period is requested. This proposal trains students to develop competence in the fields of chemistry and biology. Students learn the language and techniques to manipulate biological systems at the molecular level, which is the key for the design of rational means of diagnosis and treatment of pathological processes. Reciprocally, study of biological problems leads to the development of new synthetic and mechanistic tools in the chemical sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM066698-09
Application #
8293419
Study Section
Special Emphasis Panel (ZGM1-BRT-X (TG))
Program Officer
Fabian, Miles
Project Start
2004-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$340,796
Indirect Cost
$16,980
Name
University of California Berkeley
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Hickey, Scott F; Hammond, Ming C (2014) Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs. Chem Biol 21:345-56
Obermeyer, Allie C; Jarman, John B; Francis, Matthew B (2014) N-terminal modification of proteins with o-aminophenols. J Am Chem Soc 136:9572-9
Oestreich, Kenneth J; Read, Kaitlin A; Gilbertson, Sarah E et al. (2014) Bcl-6 directly represses the gene program of the glycolysis pathway. Nat Immunol 15:957-64
Wilson, Stephen C; Cohen, Daniel T; Wang, Xin C et al. (2014) A neutral pH thermal hydrolysis method for quantification of structured RNAs. RNA 20:1153-60
Weeks, Amy M; Keddie, Neil S; Wadoux, Rudy D P et al. (2014) Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase FlK. Biochemistry 53:2053-63
Walker, Mark C; Chang, Michelle C Y (2014) Natural and engineered biosynthesis of fluorinated natural products. Chem Soc Rev 43:6527-36
Mackenzie, Katherine J; Francis, Matthew B (2013) Recyclable thermoresponsive polymer-cellulase bioconjugates for biomass depolymerization. J Am Chem Soc 135:293-300
Jeffrey, Jenna L; Bartlett, Emily S; Sarpong, Richmond (2013) Intramolecular C(sp3)-N coupling by oxidation of benzylic C,N-dianions. Angew Chem Int Ed Engl 52:2194-7
Knight, Abigail S; Zhou, Effie Y; Pelton, Jeffrey G et al. (2013) Selective chromium(VI) ligands identified using combinatorial peptoid libraries. J Am Chem Soc 135:17488-93
Capehart, Stacy L; Coyle, Michael P; Glasgow, Jeff E et al. (2013) Controlled integration of gold nanoparticles and organic fluorophores using synthetically modified MS2 viral capsids. J Am Chem Soc 135:3011-6

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