The Molecular Pharmacology Training Program fulfills a critical need in pre-doctoral training at NYU School of Medicine, as it is the sole program devoted to the Pharmacological Sciences, therapeutics and drug design. The Molecular Pharmacology Training Program is broad-based but unified by the single major objective of this program: to produce trainees who are skilled, rigorous and imaginative scientists in the area of pharmacological sciences with an in depth focus on therapeutics. The overall long-term objective of the training program is to train subsequent generations of researchers in the study of pharmacological sciences and to apply these principles to understanding and treating malignancies and neurodegenerative disease. The training program is comprised of 38 faculty who are highly productive scientists with extensive mentoring experience. The faculty trainers all share a common interest in understanding basic pharmacological mechanisms as their contribution to chronic and life-threatening human disease. Broad training in the molecular pharmacology, strategies for drug intervention and drug delivery, mechanisms of drug resistance, processes that determine cellular responses to therapeutic agents and translational research is provided to all trainees in a highly interactive scientific environment. The mission of this training program will be achieved in a rigorous and intellectually demanding research environment spanning basic science and clinical departments that encourages diversity. Trainees will acquire the ability to critically evaluate the literature and scientific data and wil develop written and presentation skills. Training of students includes an individual development plan, and rigorous course work in principles of pharmacology, receptor pharmacology, drug design, protein modifications, quantitative skills, and translational research. The training program has established a successful system for evaluating, mentoring, and soliciting trainee feedback. Furthermore, all trainees participate in a weekly program-wide work-in-progress seminar series, an annual retreat, lectures focusing on ethical conduct in science, and career development. Our tradition of strong programmatic leadership and guidance, a well- crafted training program with proven results spanning more than 16 years, experienced and committed faculty trainers, productive and diverse trainees, in an outstanding scientific environment with key expertise in signal transduction, pharmacology, bioinformatics, structural biology, neurobiology will enable our continued success going forward. The Molecular Pharmacology Training Program request funds to continue supporting 4 pre- doctoral trainees. These trainees represent the next generation of scientists who will contribute to the development of novel pharmacological therapies to treat diseases. Significantly, trainees educated in Pharmacological Sciences continue to be of great importance to protect our nation and society at large against ageing-related diseases like cancer, diabetes and neurodegeneration.

Public Health Relevance

Millions of pre-mature deaths and tremendous cost to society are associated with the inability to effectively treat cancer and neurodegenerative diseases with existing pharmacological agents. These and other sobering statistics all too clear illustrate the need to recruit and train the next generation of scientists with expertise in pharmacology to the study how malignancies and neurodegenerative disorders are caused in humans and to design/develop new therapies against these diseases. This application proposes to educate trainees in basic pharmacological sciences as these scientists continue to be of great importance to protect our nation and society at large against the continuing threat posed by these ageing-related diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM066704-13
Application #
9063572
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Okita, Richard T
Project Start
2002-12-01
Project End
2019-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
13
Fiscal Year
2016
Total Cost
Indirect Cost
Name
New York University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Radke, Emily E; Brown, Stuart M; Pelzek, Adam J et al. (2018) Hierarchy of human IgG recognition within the Staphylococcus aureus immunome. Sci Rep 8:13296
Peng, Katherine Y; Pérez-González, Rocío; Alldred, Melissa J et al. (2018) Apolipoprotein E4 genotype compromises brain exosome production. Brain :
Kaur, Gurjinder; Gauthier, Sebastien A; Perez-Gonzalez, Rocio et al. (2018) Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome. Neurobiol Dis 120:165-173
Billerbeck, Sonja; Brisbois, James; Agmon, Neta et al. (2018) A scalable peptide-GPCR language for engineering multicellular communication. Nat Commun 9:5057
Grmai, Lydia; Hudry, Bruno; Miguel-Aliaga, Irene et al. (2018) Chinmo prevents transformer alternative splicing to maintain male sex identity. PLoS Genet 14:e1007203
Ricarte, Florante R; Le Henaff, Carole; Kolupaeva, Victoria G et al. (2018) Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling. J Biol Chem 293:20200-20213
de la Parra, Columba; Walters, Beth A; Geter, Phillip et al. (2018) Translation initiation factors and their relevance in cancer. Curr Opin Genet Dev 48:82-88
Shekhar, Akshay; Lin, Xianming; Lin, Bin et al. (2018) ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes. Sci Rep 8:9944
Shen, Michael J; Wu, Yi; Yang, Kun et al. (2018) Heterozygous diploid and interspecies SCRaMbLEing. Nat Commun 9:1934
Weber, Hannah; Garabedian, Michael J (2018) The mediator complex in genomic and non-genomic signaling in cancer. Steroids 133:8-14

Showing the most recent 10 out of 59 publications