This application seeks to establish a graduate training program (predoctoral only) in the field of marine biotechnology and biomedical research. The new program would be centered within the Center for Marine Biotechnology and Biomedicine (CMBB) at the Scripps Institution of Oceanography (SIO), University of California, San Diego, and would involve participation from numerous departments and graduate programs at UCSD. The Traininq Program in Marine Biotechnology, TPMB, is proposed as a major training opportunity for students interested in careers in the broad disciplines of marine biomedicinals, marine biomaterials research, bioremediation, marine microbiology and molecular biology, marine genomics, and marine life as models of evolution, metabolism and physiology. The program is proposed by an ambitious group of 23 faculty who will collaborate to create an unprecedented program that links new marine and biomedical technologies. The marine biotechnology and biomedicine discipline is one of the most highly subscribed graduate research areas within SIO. The opportunity to create a separate Training Program will provide stability in our teaching efforts and result in an entirely new educational opportunity not found elsewhere. Our emphasis on combining marine biotechnologies with recent advances in biomedical science is not available in related centers. Our excellent research capabilities at UCSD in the Schools of Engineering, Marine Science and Medicine provide training opportunities that easily transcend traditional departmental boundaries. Lastly, the La Jolla area has grown to become one of the world's most impressive industrial biotechnology communities. Together, these resources will create a multidisciplinary training experience difficult to achieve elsewhere.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM067550-02
Application #
6904587
Study Section
Special Emphasis Panel (ZGM1-BRT-0 (04))
Program Officer
Jones, Warren
Project Start
2004-07-01
Project End
2009-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$136,879
Indirect Cost
Name
University of California San Diego
Department
Zoology
Type
Schools of Earth Sciences/Natur
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Skiba, Meredith A; Sikkema, Andrew P; Moss, Nathan A et al. (2018) Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. ACS Chem Biol 13:1640-1650
Gallagher, Kelley A; Wanger, Greg; Henderson, Jane et al. (2017) Ecological implications of hypoxia-triggered shifts in secondary metabolism. Environ Microbiol 19:2182-2191
Skiba, Meredith A; Sikkema, Andrew P; Moss, Nathan A et al. (2017) A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. ACS Chem Biol 12:3039-3048
Kinnel, Robin B; Esquenazi, Eduardo; Leao, Tiago et al. (2017) A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. J Nat Prod 80:1514-1521
Naman, C Benjamin; Rattan, Ramandeep; Nikoulina, Svetlana E et al. (2017) Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. J Nat Prod 80:625-633
León-Zayas, Rosa; Peoples, Logan; Biddle, Jennifer F et al. (2017) The metabolic potential of the single cell genomes obtained from the Challenger Deep, Mariana Trench within the candidate superphylum Parcubacteria (OD1). Environ Microbiol 19:2769-2784
Moss, Nathan A; Bertin, Matthew J; Kleigrewe, Karin et al. (2016) Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. J Ind Microbiol Biotechnol 43:313-24
El Gamal, Abrahim; Agarwal, Vinayak; Diethelm, Stefan et al. (2016) Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proc Natl Acad Sci U S A 113:3797-802
Russell, Joseph A; León-Zayas, Rosa; Wrighton, Kelly et al. (2016) Deep Subsurface Life from North Pond: Enrichment, Isolation, Characterization and Genomes of Heterotrophic Bacteria. Front Microbiol 7:678
Castro-Falcón, Gabriel; Hahn, Dongyup; Reimer, Daniela et al. (2016) Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action. ACS Chem Biol 11:2328-36

Showing the most recent 10 out of 49 publications