We describe a pre-doctoral training program in Cellular, Biochemical and Molecular Biology that is based on our strong core community of interactive investigators in the fields of RNA, DNA, and protein biochemistry. The proposed training program capitalizes on (i) a major initiative that continues to expand research and education at the University of Rochester Medical Center (URMC), and (ii) enhanced educational choices and opportunities resulting from recent reorganization of Graduate Education in Biomedical Sciences (GEBS) at the University of Rochester. Key aspects of the proposal include: 1) improved support for students performing interdisciplinary research;2) new opportunities for direct interactions between students and visiting seminar speakers and lecturers, including a new seminar-based course;3) new opportunities for offsite student travel to attend meetings, take courses, and work in labs outside the University of Rochester;4) enhanced counseling for female and minority students aimed at helping them achieve long-term career goals;5) increased interactions among investigators and students in the areas of RNA, DNA, and protein biochemistry through a common set of course requirements and a yearly retreat;and 6) more effective student recruiting made possible by these training grant educational benefits. The University is now benefiting from a major commitment initiated by the URMC eight years ago to expand basic and applied medical research. There are (i) two new research facilities totaling 400,000 sq. ft. and (ii) start-up funding for new programs in Biochemistry, Structural Biology, Genetics, Virology, Signal Transduction, Immunology, and Neurobiology that aims to increase the number of PIs from 150 to ~250. In the past three years, graduate programs at the URMC have been completely restructured to accommodate the expansion in research and to increase the breadth of training for students. Students are accepted into multidisciplinary """"""""Clusters"""""""" that constitute GEBS. They are exposed to diverse research areas in the first year through courses, faculty research presentations, and lab rotations. Students then choose a research advisor and degree program from a wide range of possibilities at the URMC and the College of Arts and Sciences. This program has greatly promoted scientific interactions among laboratories, increased flexibility in the choice of research mentors, and improved graduate recruiting.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM068411-05
Application #
7642274
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
2005-07-01
Project End
2010-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
5
Fiscal Year
2009
Total Cost
$264,260
Indirect Cost
Name
University of Rochester
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Berger, Kyle D; Kennedy, Scott D; Schroeder, Susan J et al. (2018) Surprising Sequence Effects on GU Closure of Symmetric 2 × 2 Nucleotide RNA Internal Loops. Biochemistry 57:2121-2131
Trembley, Michael A; Quijada, Pearl; Agullo-Pascual, Esperanza et al. (2018) Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy. Circulation 138:1864-1878
Loelius, Shannon G; Lannan, Katie L; Blumberg, Neil et al. (2018) The HIV protease inhibitor, ritonavir, dysregulates human platelet function in vitro. Thromb Res 169:96-104
Loelius, Shannon G; Spinelli, Sherry L; Lannan, Katie L et al. (2018) In Vitro Methods to Characterize the Effects of Tobacco and Nontobacco Products on Human Platelet Function. Curr Protoc Toxicol 76:e46
Cho, Hana; Rambout, Xavier; Gleghorn, Michael L et al. (2018) Transcriptional coactivator PGC-1? contains a novel CBP80-binding motif that orchestrates efficient target gene expression. Genes Dev 32:555-567
Trewin, Adam J; Berry, Brandon J; Wei, Alicia Y et al. (2018) Light-induced oxidant production by fluorescent proteins. Free Radic Biol Med 128:157-164
Trewin, Adam J; Berry, Brandon J; Wojtovich, Andrew P (2018) Exercise and Mitochondrial Dynamics: Keeping in Shape with ROS and AMPK. Antioxidants (Basel) 7:
Barnett, Miriam E; Baran, Timothy M; Foster, Thomas H et al. (2018) Quantification of light-induced miniSOG superoxide production using the selective marker, 2-hydroxyethidium. Free Radic Biol Med 116:134-140
Walling, Lauren R; Butler, J Scott (2018) Homologous VapC Toxins Inhibit Translation and Cell Growth by Sequence-Specific Cleavage of tRNAfMet. J Bacteriol 200:
Berry, Brandon J; Trewin, Adam J; Amitrano, Andrea M et al. (2018) Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species. J Mol Biol 430:3873-3891

Showing the most recent 10 out of 123 publications