The goal of this program is to develop and prepare skilled, science-based surgeons for productive academic careers focusing on trauma and burn care. To accomplish this goal, we believe that trainees should be placed in basic-science oriented laboratories conducting investigations of clinically pertinent questions. The experience provided is designed to educate the trainee in the rigors of the applied scientific method, instill a respect for biological systems and endow them with the curiosity and tools to explore all potential avenues of investigation for problem-solving. We believe that the principles of scientific research and experimental methodology can best be taught in a setting where these are the primary activities of the participants, while providing experiences which can be incorporated into their already established, clinically applicable framework. We also will stress that all trainees will be exposed to a wide array of techniques and approaches, including, but not limited to animal models, molecular biology, immunology and physiology. ? ? This proposal requests five years of support for post-doctoral fellows to spend two years in an academic environment to develop physician-scientists interested in trauma / critical care research. We are requesting 3 trainees with two years' relevant postdoctoral experience to enter the program in the first year, with 3 more to be added in the second year, for a total of 6. Candidates for the program will be recruited nationally and from various NJMS departments, generally after their second post-graduate year. Trainees will work and study with a multidisciplinary group of faculty members, most of whom have been working together for many years. The basic training core consists primarily of course work, seminars, lectures, trainee presentations and meetings. For the bench research component, a trainee is directly responsible for a primary project that he or she may propose or may be assigned. Trainees also participate in research projects of other trainees and investigators, and cooperation in research is emphasized. All projects proceed under the close tutelage of a scientific mentor, and with the collaboration of other program faculty members. ? ? This training grant will take advantage of a diversified set of projects led by funded and established investigators, all of whom are intimately related to trauma and inflammation research. There is an Executive Advisory Committee to provide the principal investigator with advice and reviews of all aspects of the program. The training faculty has worked together for many years as evidenced by joint publications and grants and is enthusiastically looking forward to developing physician-scientists in the important area of trauma and critical care. ? ?

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Somers, Scott D
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University of Medicine & Dentistry of NJ
Schools of Medicine
United States
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Gore, Amy V; Bible, Letitia E; Livingston, David H et al. (2016) Mesenchymal stem cells enhance lung recovery after injury, shock, and chronic stress. Surgery 159:1430-5
Bible, Letitia E; Pasupuleti, Latha V; Gore, Amy V et al. (2015) Chronic restraint stress after injury and shock is associated with persistent anemia despite prolonged elevation in erythropoietin levels. J Trauma Acute Care Surg 79:91-6; discussion 96-7
Gore, Amy V; Bible, Letitia E; Song, Kimberly et al. (2015) Mesenchymal stem cells increase T-regulatory cells and improve healing following trauma and hemorrhagic shock. J Trauma Acute Care Surg 79:48-52; discussion 52
Gore, Amy V; Bible, Letitia E; Livingston, David H et al. (2015) Can mesenchymal stem cells reverse chronic stress-induced impairment of lung healing following traumatic injury? J Trauma Acute Care Surg 78:767-72
Gore, Amy V; Bible, Letitia E; Livingston, David H et al. (2015) Mesenchymal stem cells reverse trauma and hemorrhagic shock-induced bone marrow dysfunction. J Surg Res 199:615-21
Bible, Letitia E; Pasupuleti, Latha V; Gore, Amy V et al. (2015) Daily propranolol prevents prolonged mobilization of hematopoietic progenitor cells in a rat model of lung contusion, hemorrhagic shock, and chronic stress. Surgery 158:595-601
Gore, Amy V; Bible, Letitia E; Livingston, David H et al. (2015) Mesenchymal stem cells reverse bone marrow dysfunction following injury and stress. J Trauma Acute Care Surg 79:602-8
Bonitz, Joyce A; Son, Julie Y; Chandler, Benjamin et al. (2014) A sphingosine-1 phosphate agonist (FTY720) limits trauma/hemorrhagic shock-induced multiple organ dysfunction syndrome. Shock 42:448-55
Fishman, Jordan E; Levy, Gal; Alli, Vamsi et al. (2014) The intestinal mucus layer is a critical component of the gut barrier that is damaged during acute pancreatitis. Shock 42:264-70
Fishman, Jordan E; Sheth, Sharvil U; Levy, Gal et al. (2014) Intraluminal nonbacterial intestinal components control gut and lung injury after trauma hemorrhagic shock. Ann Surg 260:1112-20

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