The goal of this program is to develop and prepare skilled, science-based surgeons for productive academic careers focusing on trauma and critical care. To accomplish this goal, we believe that trainees should be placed in basic science oriented laboratories conducting investigations of clinically pertinent questions. The experience provided is designed to educate the trainee in the rigors of the applied scientific method, instill a respect for biological systems and endow them with the curiosity and tools to explore all potential avenues of investigation for problem-solving. We believe that the principles of scientific research and experimental methodology can best be taught in a setting where these are the primary activities of the participants, while providing experiences which can be incorporated into their already established, clinically applicable framework. We also stress that all trainees be exposed to a wide array of techniques and approaches, including, but not limited to animal models, molecular biology, immunology and physiology. This proposal request five years of support for post-doctoral fellows to spend two years in an academic environment to develop physician-scientists interested in trauma / critical care research. We are requesting 2 trainees per year for a total of 4 per year. Candidates for the program are recruited nationally and from various NJMS departments, generally after their second post-graduate year. Trainees work and study with a multidisciplinary group of faculty members, most of whom have been working together for years. The basic training core consists primarily of course work, seminars, lectures, trainee presentations and meetings. The bench research component, a trainee is directly responsible for a primary project that he or she may propose or may be assigned. Trainees also participate in research projects of other trainees and investigators as cooperation in research is emphasized. All projects proceed under the close tutelage of a scientific mentor and with the collaboration of other program faculty members. This training grant takes advantage of a diversified set of projects led by funded and established investigators, all of whom are intimately related to trauma and inflammation research.

Public Health Relevance

The goal of this program is to develop and prepare skilled, science-based surgeons for productive academic careers focusing on trauma and critical care. To accomplish this goal, we believe that trainees should be placed in basic science oriented laboratories conducting investigations of clinically pertinent questions. The experience provided is designed to educate the trainee in the rigors of the applied scientific method, instill a respect for biological systems and endow them with the curiosity and tools to explore all potential avenues of investigation for problem-solving.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM069330-06A2
Application #
8017964
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Somers, Scott D
Project Start
2004-07-01
Project End
2016-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
6
Fiscal Year
2011
Total Cost
$171,623
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Surgery
Type
Schools of Medicine
DUNS #
623946217
City
Newark
State
NJ
Country
United States
Zip Code
07107
Gore, Amy V; Bible, Letitia E; Livingston, David H et al. (2016) Mesenchymal stem cells enhance lung recovery after injury, shock, and chronic stress. Surgery 159:1430-5
Bible, Letitia E; Pasupuleti, Latha V; Gore, Amy V et al. (2015) Daily propranolol prevents prolonged mobilization of hematopoietic progenitor cells in a rat model of lung contusion, hemorrhagic shock, and chronic stress. Surgery 158:595-601
Gore, Amy V; Bible, Letitia E; Livingston, David H et al. (2015) Mesenchymal stem cells reverse trauma and hemorrhagic shock-induced bone marrow dysfunction. J Surg Res 199:615-21
Bible, Letitia E; Pasupuleti, Latha V; Gore, Amy V et al. (2015) Chronic restraint stress after injury and shock is associated with persistent anemia despite prolonged elevation in erythropoietin levels. J Trauma Acute Care Surg 79:91-6; discussion 96-7
Gore, Amy V; Bible, Letitia E; Livingston, David H et al. (2015) Mesenchymal stem cells reverse bone marrow dysfunction following injury and stress. J Trauma Acute Care Surg 79:602-8
Gore, Amy V; Bible, Letitia E; Song, Kimberly et al. (2015) Mesenchymal stem cells increase T-regulatory cells and improve healing following trauma and hemorrhagic shock. J Trauma Acute Care Surg 79:48-52; discussion 52
Gore, Amy V; Bible, Letitia E; Livingston, David H et al. (2015) Can mesenchymal stem cells reverse chronic stress-induced impairment of lung healing following traumatic injury? J Trauma Acute Care Surg 78:767-72
Son, Julie Y; Chandler, Benjamin; Feketova, Eleonora et al. (2014) Oral pretreatment with recombinant human lactoferrin limits trauma-hemorrhagic shock-induced gut injury and the biological activity of mesenteric lymph. J Surg Res 187:270-7
Bonitz, Joyce A; Son, Julie Y; Chandler, Benjamin et al. (2014) A sphingosine-1 phosphate agonist (FTY720) limits trauma/hemorrhagic shock-induced multiple organ dysfunction syndrome. Shock 42:448-55
Bible, Letitia E; Pasupuleti, Latha V; Alzate, Walter D et al. (2014) Early propranolol administration to severely injured patients can improve bone marrow dysfunction. J Trauma Acute Care Surg 77:54-60; discussion 59-60

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