This application requests funds to support the training of predoctoral students in the Program in Molecular and Cellular Biosciences (PMCB) at Oregon Health &Science University. This interdisciplinary program brings together 156 faculty from five basic science departments (Biochemistry and Molecular Biology;Cell and Developmental Biology;Molecular and Medical Genetics;Molecular Microbiology and Immunology;and Physiology and Pharmacology), the Cancer Biology Program and affiliated research institutes to provide first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists. This proposal will support stipends for 7 Ph.D. students out of the 115 currently enrolled in the PMCB for their first two years of training. The 80-member training faculty in this application are internationally recognized for their expertise in biophysical, molecular, cellular, and developmental approaches to important and compelling biological questions using state-of-the art methodologies. Notably, graduate students directly participate in ground-breaking translational research, ranging from establishment of new therapies that improve cancer survival to new insights into stem cell biology, the molecular basis of neurogenesis and energy homeostasis, protein structure and chemical biology, and vaccine development. Our program offers qualified students a common, rigorous didactic grounding for the first year and continued grounding as students begin to specialize during their second year. Students also participate in seminar series, program retreats, teaching, and may attend scientific meetings. Students must successfully pass a comprehensive written exam at the end of their first year and a qualifying exam at the end of their second year, in which they prepare and defend an original research proposal. Subsequently, students are formally admitted to one of the five participating departments to conduct a research project leading to the awarding of a Doctorate of Philosophy. Importantly, the dynamic research community at OHSU, combined with the proximity of basic and clinical research facilities, provides a unique opportunity for Ph.D. students to form cross-discipline collaborations during their training and to gain an appreciation of the health-relatedness of the basic sciences.

Public Health Relevance

The studies proposed in this application will provide training for first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists in biomedical sciences. Trainees will learn state-of-the-art methods so that they may participate in ground-breaking basic and bench-to-bedside research that will improve the quality of healthcare in the future.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Anatomy/Cell Biology
Schools of Medicine
United States
Zip Code
Watanabe-Smith, K; Tognon, C; Tyner, J W et al. (2016) Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia. Leukemia 30:1950-3
Martin, Jessica L; Yates, Phillip A; Boitz, Jan M et al. (2016) A role for adenine nucleotides in the sensing mechanism to purine starvation in Leishmania donovani. Mol Microbiol 101:299-313
Schafer, Christopher T; Fay, Jonathan F; Janz, Jay M et al. (2016) Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state. Proc Natl Acad Sci U S A 113:11961-11966
Almubarak, Sarah; Nethercott, Hubert; Freeberg, Marie et al. (2016) Tissue engineering strategies for promoting vascularized bone regeneration. Bone 83:197-209
Maxson, Julia E; Davare, Monika A; Luty, Samuel B et al. (2015) Therapeutically Targetable ALK Mutations in Leukemia. Cancer Res 75:2146-50
Stickles, Allison M; Ting, Li-Min; Morrisey, Joanne M et al. (2015) Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy. Am J Trop Med Hyg 92:1195-201
Javidi-Sharifi, Nathalie; Traer, Elie; Martinez, Jacqueline et al. (2015) Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance. Cancer Res 75:880-91
Agarwal, A; MacKenzie, R J; Eide, C A et al. (2015) Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia. Oncogene 34:2991-9
Morin, Gabriela; Robinson, Bridget A; Rogers, Kelsey S et al. (2015) A Rhesus Rhadinovirus Viral Interferon (IFN) Regulatory Factor Is Virion Associated and Inhibits the Early IFN Antiviral Response. J Virol 89:7707-21
Yaeger, Daniel B; Trussell, Laurence O (2015) Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci 35:4741-50

Showing the most recent 10 out of 88 publications