The goal of this predoctoral training program is to provide students with the intellectual and technical skills required to solve important and complex biological problems that can be most effectively addressed by studies at the chemistry-biology interface, and to create a group of graduating chemists and biologists who can effectively communicate and function successfully in multidisciplinary teams. The focus of the training program is mechanistic chemistry of biomolecules, which is a theme that is of special interest to a significant population of faculty and students on campus, and provides an excellent model system for the application of chemical tools to solve important biological problems. The Program involves 29 participating faculty from The Wistar Institute and two separate Schools within the University of Pennsylvania, The School of Medicine and The School of Arts and Sciences. Participating students come primarily from two graduate groups that span institution and school boundaries, the Graduate Group in Chemistry and the Graduate Group in Biochemistry and Biophysics. Students typically join the program when they matriculate and a subset of these students is funded on the training grant after they have chosen a thesis laboratory at the beginning of their second year. We request funding for 9 students. To insure cross-fertilization between the chemistry and biology students, those in the OBI program carry out dissertation research at the chemistry-biology interface with a CBI trainer and also participate in the following activities: (1) A course curriculum that crosses the chemistry- biology academic boundary and centers around the mechanistic chemistry of biomolecules, (2) A student run speaker-invited thrice-yearly Chemical Biophysics mini-symposia seminar series centered around the chemistry-biology interface, (3) A monthly luncheon in which CBI students and faculty informally discuss their research among themselves, and (4) An annual Chemistry-Biology Interface Retreat in which students interact and present their work to each other and other trainees and trainers. The program also has effective mechanisms in place for instruction in the responsible conduct of research and the recruitment of underrepresented minorities, the disadvantaged and the disabled. A training committee is comprised of roughly equal faculty representation from the three participating programs and trainee representatives, which meets annually. The training committee is responsible for selecting students for training slot positions, insures equitable distribution of students, encourages application from underrepresented minorities, the disadvantaged and disabled and administers other functions of the grant.

Public Health Relevance

Research at the Chemistry-Biology Interface forms a cornerstone for understanding the detailed molecular mechanisms of molecules that mediate cellular functions during health as well as disease when certain molecules, such as proteins, have aberrant function. Once these aberrant protein activities are understood at the molecular level, research at the Chemistry-Biology Interface can lead to the development of therapeutic agents, such as drugs, to treat diseases like cancer, cardiovascular abnormalities and metabolic disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM071339-07
Application #
8101268
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Fabian, Miles
Project Start
2005-08-05
Project End
2015-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
7
Fiscal Year
2011
Total Cost
$220,940
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
075524595
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Magin, Robert S; Deng, Sunbin; Zhang, Haibo et al. (2017) Probing the interaction between NatA and the ribosome for co-translational protein acetylation. PLoS One 12:e0186278
Chen, Xing; Mietlicki-Baase, Elizabeth G; Barrett, Taylor M et al. (2017) Thioamide Substitution Selectively Modulates Proteolysis and Receptor Activity of Therapeutic Peptide Hormones. J Am Chem Soc 139:16688-16695
Sungwienwong, Itthipol; Hostetler, Zachary M; Blizzard, Robert J et al. (2017) Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection. Org Biomol Chem 15:3603-3610
Haney, Conor M; Cleveland, Christina L; Wissner, Rebecca F et al. (2017) Site-Specific Fluorescence Polarization for Studying the Disaggregation of ?-Synuclein Fibrils by Small Molecules. Biochemistry 56:683-691
Porter, Nicholas J; Mahendran, Adaickapillai; Breslow, Ronald et al. (2017) Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc Natl Acad Sci U S A 114:13459-13464
Karch, Kelly R; Langelier, Marie-France; Pascal, John M et al. (2017) The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage. Mol Biosyst 13:2660-2671
March, Zachary M; King, Oliver D; Shorter, James (2016) Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease. Brain Res 1647:9-18
Zhang, Huixi Violet; Polzer, Frank; Haider, Michael J et al. (2016) Computationally designed peptides for self-assembly of nanostructured lattices. Sci Adv 2:e1600307
Newmister, Sean A; Gober, Claire M; Romminger, Stelamar et al. (2016) OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30. J Am Chem Soc 138:11176-84
Gober, Claire M; Carroll, Patrick J; JoulliƩ, Madeleine M (2016) Triazaspirocycles: Occurrence, Synthesis, and Applications. Mini Rev Org Chem 13:126-142

Showing the most recent 10 out of 70 publications