Nationally, trends suggest that there are diminishing numbers of academic physician investigators. Thus, there is a need to train a cadre of future scientists who can link their research to clinical care to address the trends, causes, and treatment of disease. The Indiana University Medical Scientist/Engineer Training Program (MSTP) was conceived to meet this need, and this application represents the first competitive renewal of the Indiana MSTP since its funding almost 4 years ago. A unique and notable aspect of our program is the integration of faculty within the Weldon School of Biomedical Engineering at Purdue University to include the exceptional training of physician engineers.
The aim of the Indiana Medical Scientist/Engineer Training Program is to provide interdisciplinary, integrated medical and scientific research training to develop students into engaging physician investigators who are poised to pursue careers in hypothesis-driven research that advances human health. With the support from a large, dedicated endowment to the program, the new PI of this application (Dr. R. Mirmira, himself a graduate of an MSTP) and his Co-Director (Dr. M. Harrington) have taken important and progressive steps to enhance physician scientist training, including the introduction of clinical experiences during graduate training, expansion of seminars/enrichment activities, and institution of formal internal and external feedback policies to implement programmatic changes. In close collaboration with the Weldon School of Biomedical Engineering at Purdue University, we have designed and implemented a flexible curriculum that provides in-depth training for students in a specific area of science and/or engineering relevant to human disease. Our program emphasizes coursework that broadens research training at the bench with quantitative skills, provides opportunities for public speaking provides a range of enriching extracurricular opportunities, and allows for integration of medicine and science/engineering throughout all years of training. Defined oversight mechanisms are in place to track the progress of trainees throughout the program. With the help of our outreach activities and the MSTP designation, our program notoriety has grown tremendously, as evidenced by a 400% increase in our applicant pool over the past 10 years and the remarkable diversity of our current student pool (23% underrepresented or with documented disabilities and 44% from out-of-state). In this competitive renewal application, we will build upon our successes and to make the necessary programmatic adjustments going forward to ensure that our trainees continue to be prepared to become future scientists and engineers who pioneer advances in medical practice through research.
Nationally, trends suggest diminishing numbers of physician scientist;as a result, there is a need to train a cadre of future scientists who can link their research to clinical care to address the trends, causes, and treatment of disease. The Indiana University Medical Scientist/Engineer Training Program was conceived to meet this need. This application describes our ongoing program to train the next generation of physician scientists who will become leaders in research and clinical care.
|Craven, Kelly E; Gore, Jesse; Wilson, Julie L et al. (2016) Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomes. Oncotarget 7:323-41|
|Farlow, Janice L; Robak, Laurie A; Hetrick, Kurt et al. (2016) Whole-Exome Sequencing in Familial Parkinson Disease. JAMA Neurol 73:68-75|
|Ferguson, Michael J; Rhodes, Steven D; Jiang, Li et al. (2016) Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas. Pediatr Blood Cancer 63:206-13|
|Lin, Jenny B; Poh, Scott; Panitch, Alyssa (2016) Controlled release of anti-inflammatory peptides from reducible thermosensitive nanoparticles suppresses cartilage inflammation. Nanomedicine 12:2095-2100|
|Sehra, Sarita; Serezani, Ana P M; OcaÃ±a, Jesus A et al. (2016) Mast Cells Regulate Epidermal Barrier Function and the Development of AllergicÂ Skin Inflammation. J Invest Dermatol 136:1429-37|
|Goodwill, Adam G; Noblet, Jillian N; Sassoon, Daniel et al. (2016) Critical contribution of KV1 channels to the regulation of coronary blood flow. Basic Res Cardiol 111:56|
|Cao, Yingchun; Hui, Jie; Kole, Ayeeshik et al. (2016) High-sensitivity intravascular photoacoustic imaging of lipid-laden plaque with a collinear catheter design. Sci Rep 6:25236|
|Gore, A Jesse; Deitz, Samantha L; Palam, Lakshmi Reddy et al. (2016) Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-Î² to promote proliferation. J Clin Invest 126:2774|
|Sassoon, Daniel J; Goodwill, Adam G; Noblet, Jillian N et al. (2016) Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism. Basic Res Cardiol 111:43|
|Craven, Kelly E; Gore, Jesse; Korc, Murray (2016) Overview of pre-clinical and clinical studies targeting angiogenesis in pancreatic ductal adenocarcinoma. Cancer Lett 381:201-10|
Showing the most recent 10 out of 64 publications