This proposal seeks support for a training program at the Chemistry-Biology Interface (CBI) at Johns Hopkins University. The goal is to train predoctoral students to carry out biomedical research using the tools of Chemistry and Biology. The Program is a collaborative effort between faculty in the Departments of Biochemistry and Molecular Biology (Bloomberg School of Public Health) and Pharmacology and Molecular Sciences (School of Medicine), with their colleagues in the Biology and Chemistry Departments (Zanvyl Krieger School of Arts & Sciences). Student participants will have a diverse array of research projects including synthesis, mechanism, enzymology, molecular imaging, and biomacromolecular structure to choose from in 26 research groups. The students will receive coursework training in the biological and chemical sciences, including a two-semester course in Chemical Biology designed especially for the Program, but open to all Johns Hopkins University students. Other aspects of the CBI Program include CBI Forum where students will present literature seminars, defend original research proposals, and defend their theses, as well as an Annual Retreat. The CBI Program was initiated in fall 2005 using funding from the University and will consist of 6 students in fall 2006. Support is requested to support 4 graduate students, increasing to 6 students in year 3, as the momentum of the Program increases. An extensive network of support in the form of advising and mentoring is in place to maximize the students' success. Relevance: The roles of chemistry and biology in basic and applied biomedical research are of paramount importance. There is a rapidly increasing need for scientists who can traverse both fields of science. The CBI Program at Johns Hopkins University will train scientists with this ability. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
1T32GM080189-01A1
Application #
7438366
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Rogers, Michael E
Project Start
2008-07-01
Project End
2013-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
1
Fiscal Year
2008
Total Cost
$173,175
Indirect Cost
Name
Johns Hopkins University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Johnson, Eric A; Russo, Miranda M; Nye, Dillon B et al. (2018) Lysine as a heme iron ligand: A property common to three truncated hemoglobins from Chlamydomonas reinhardtii. Biochim Biophys Acta Gen Subj 1862:2660-2673
Saraiva, Raúl G; Huitt-Roehl, Callie R; Tripathi, Abhai et al. (2018) Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin. Sci Rep 8:6176
Sanders, Sara; Bartee, David; Harrison, Mackenzie J et al. (2018) Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors. PLoS One 13:e0197638
Herbst, Dominik A; Huitt-Roehl, Callie R; Jakob, Roman P et al. (2018) The structural organization of substrate loading in iterative polyketide synthases. Nat Chem Biol 14:474-479
Nye, Dillon B; Preimesberger, Matthew R; Majumdar, Ananya et al. (2018) Histidine-Lysine Axial Ligand Switching in a Hemoglobin: A Role for Heme Propionates. Biochemistry 57:631-644
Singh, Digvijay; Wang, Yanbo; Mallon, John et al. (2018) Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis. Nat Struct Mol Biol 25:347-354
Bartee, David; Freel Meyers, Caren L (2018) Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism. Acc Chem Res 51:2546-2555
Boucher, Lauren E; Hopp, Christine S; Muthinja, Julianne Mendi et al. (2018) Discovery of Plasmodium (M)TRAP-Aldolase Interaction Stabilizers Interfering with Sporozoite Motility and Invasion. ACS Infect Dis 4:620-634
Nye, Dillon B; Lecomte, Juliette T J (2018) Replacement of the Distal Histidine Reveals a Noncanonical Heme Binding Site in a 2-on-2 Hemoglobin. Biochemistry 57:5785-5796
Gonzalez-Gil, Anabel; Porell, Ryan N; Fernandes, Steve M et al. (2018) Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways. Glycobiology 28:786-801

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