This proposal seeks to renew support for a training program at the Chemistry-Biology Interface (CBI) at Johns Hopkins University that was established in 2005 and received NIH support in 2008. The goal is to train predoctoral students to carry out biomedical research using the tools of Chemistry and Biology. The Program is a collaborative effort between faculty in the Departments of Biochemistry and Molecular Biology (Bloomberg School of Public Health), Pharmacology and Molecular Sciences (School of Medicine), Biophysics and Biophysical Chemistry (School of Medicine), and Chemical and Biomolecular Engineering (Whiting School of Engineering), with their colleagues in the Biology, Biophysics, and Chemistry Departments (Zanvyl Krieger School of Arts &Sciences). Student participants have a diverse array of research projects including synthesis, mechanism, enzymology, molecular imaging, and biomacromolecular structure to choose from in 32 research groups. The students receive coursework training in the biological and chemical sciences, including a two-semester course in Chemical Biology designed especially for the Program, but open to all Johns Hopkins University students. Other aspects of the CBI Program include CBI Forum where students present original research proposals, research updates, first year research rotation results, and defend their theses, as well as an Annual Retreat. The students are immersed in a common curriculum (independent of the Department in which their research advisors hold primary appointments), apply directly to the CBI Program, and receive a Ph.D. in Chemical Biology upon completion. The CBI Program was initiated in fall 2005 using funding from the University, which continues to provide a high level of support. NIH currently provides one year of support for 5 students. Support is requested for 6 graduate students. An extensive network of support in the form of advising and mentoring is in place to maximize the students'success. This has resulted in >92% retention of students since the program began in 2005.

Public Health Relevance

The roles of chemistry and biology in basic and applied biomedical research are of paramount importance. There is a rapidly increasing need for scientists who can traverse both fields of science. The CBI Program at Johns Hopkins University is training scientists with this ability.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Program Officer
Fabian, Miles
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Schools of Arts and Sciences
United States
Zip Code
Head, Sarah A; Shi, Wei Q; Yang, Eun Ju et al. (2017) Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis. ACS Chem Biol 12:174-182
Yu, Huifeng; Gonzalez-Gil, Anabel; Wei, Yadong et al. (2017) Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties. Glycobiology 27:657-668
Storm, Philip A; Herbst, Dominik A; Maier, Timm et al. (2017) Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin. Cell Chem Biol 24:316-325
Shelat, Nirav Y; Parhi, Sidhartha; Ostermeier, Marc (2017) Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase. Protein Eng Des Sel 30:95-103
Choi, Jay H; Xiong, Tina; Ostermeier, Marc (2016) The interplay between effector binding and allostery in an engineered protein switch. Protein Sci 25:1605-16
Kuznedelov, Konstantin; Mekler, Vladimir; Lemak, Sofia et al. (2016) Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation. Nucleic Acids Res 44:10849-10861
Reiter, Katherine H; Ramachandran, Anita; Xia, Xue et al. (2016) Characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems. J Biol Chem 291:3860-70
Van Voorhis, Wesley C; Adams, John H; Adelfio, Roberto et al. (2016) Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog 12:e1005763
Hansen, Erik C; Ransom, Monica; Hesselberth, Jay R et al. (2016) Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells. Elife 5:
Barajas, Jesus F; Finzel, Kara; Valentic, Timothy R et al. (2016) Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain. Angew Chem Int Ed Engl 55:13005-13009

Showing the most recent 10 out of 58 publications