The objective of this proposal is to establish a new and unique graduate training opportunity at Ohio State University (OSU), the Cellular, Molecular and Biochemical Sciences Program (CMBP). This program will draw faculty and trainees from five related molecular life sciences graduate programs: Biophysics, Microbiology, Molecular Cellular and Developmental Biology, Molecular Genetics, and the Ohio State Biochemistry Program. While these programs are very successful in training students in particular disciplines, they have not focused on providing additional coordinated interdisciplinary training opportunities as historical precedents make introduction of changes in curriculum or addition of new training modules somewhat difficult. The goal of the CMBP is to create new opportunities for student training by introducing career-advancing components. Starting with orientation week activities where students are assigned a faculty and peer mentor, and continuing with monthly research meetings, annual symposia, career workshops, ethics training, CMBP-specific courses, optional internship programs, annual evaluations, and career monitoring, CMBP trainees will experience training not available through other programs. Special CMBP features also include the requirement for a co- advisor, who will provide expertise complementary to that of the advisor on a routine basis, and a mandatory scientific writing workshop specifically developed for this program. CMBP will be a rigorous and demanding program designed to attract top students to OSU, and the breadth and depth of the training provided will position CMBP graduates to make significant contributions to biomedical research in academia, government, and industry. In the past few years, significant institutional support, together with a new Arts and Sciences College structure, has facilitated interdisciplinary research and graduate training at OSU. Thus, we feel the time is right to bring these opportunities to a new level. The resources requested in this proposal would now allow us to build on existing strengths to develop a new graduate training program that spans a broad range of topics and activities in the cellular, biochemical and molecular sciences. The unique combination of opportunities offered through the CMBP will also increase recruitment and retention of the very best graduate students, in particular from underrepresented minorities (URM), thereby building upon recent successes in similar undergraduate recruitment activities at OSU. Matching institutional support towards our goal of having one quarter of new fellowships awarded to URM students each year has been secured.
We seek to establish a new and unique graduate training opportunity at Ohio State University (OSU), the Cellular, Molecular and Biochemical Sciences Program (CMBP). This program will involve 35 faculty trainers from five related molecular life sciences graduate programs who represent the highest standards of excellence at OSU. The goal of the CMBP is to create new opportunities for student training by introducing career- advancing components, and the breadth and depth of the training provided will position CMBP graduates to make significant contributions to biomedical research in academia, government, and industry.
|Sigman, Meredith J; Slotkin, R Keith (2016) The First Rule of Plant Transposable Element Silencing: Location, Location, Location. Plant Cell 28:304-13|
|Jackel, Jamie N; Storer, Jessica M; Coursey, Tami et al. (2016) Arabidopsis RNA Polymerases IV and V Are Required To Establish H3K9 Methylation, but Not Cytosine Methylation, on Geminivirus Chromatin. J Virol 90:7529-40|
|Walker, Melissa A; Mohler, Kyle P; Hopkins, Kyle W et al. (2016) Novel Compound Heterozygous Mutations Expand the Recognized Phenotypes of FARS2-Linked Disease. J Child Neurol 31:1127-37|
|Rajkovic, Andrei; Hummels, Katherine R; Witzky, Anne et al. (2016) Translation Control of Swarming Proficiency in Bacillus subtilis by 5-Amino-pentanolylated Elongation Factor P. J Biol Chem 291:10976-85|
|Fleming, Ian M C; Paris, ZdenÄ›k; Gaston, Kirk W et al. (2016) A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei. Sci Rep 6:21438|
|Moghal, Adil; Hwang, Lin; Faull, Kym et al. (2016) Multiple Quality Control Pathways Limit Non-protein Amino Acid Use by Yeast Cytoplasmic Phenylalanyl-tRNA Synthetase. J Biol Chem 291:15796-805|
|Cataldo, Alessandra; Cheung, Douglas G; Balsari, Andrea et al. (2016) miR-302b enhances breast cancer cell sensitivity to cisplatin by regulating E2F1 and the cellular DNA damage response. Oncotarget 7:786-97|
|Fultz, Dalen; Choudury, Sarah G; Slotkin, R Keith (2015) Silencing of active transposable elements in plants. Curr Opin Plant Biol 27:67-76|
|Di Leva, Gianpiero; Cheung, Douglas G; Croce, Carlo M (2015) miRNA clusters as therapeutic targets for hormone-resistant breast cancer. Expert Rev Endocrinol Metab 10:607-617|
|McCue, Andrea D; Panda, Kaushik; Nuthikattu, Saivageethi et al. (2015) ARGONAUTE 6 bridges transposable element mRNA-derived siRNAs to the establishment of DNA methylation. EMBO J 34:20-35|
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