The objective of this proposal is to establish a new and unique graduate training opportunity at Ohio State University (OSU), the Cellular, Molecular and Biochemical Sciences Program (CMBP). This program will draw faculty and trainees from five related molecular life sciences graduate programs: Biophysics, Microbiology, Molecular Cellular and Developmental Biology, Molecular Genetics, and the Ohio State Biochemistry Program. While these programs are very successful in training students in particular disciplines, they have not focused on providing additional coordinated interdisciplinary training opportunities as historical precedents make introduction of changes in curriculum or addition of new training modules somewhat difficult. The goal of the CMBP is to create new opportunities for student training by introducing career-advancing components. Starting with orientation week activities where students are assigned a faculty and peer mentor, and continuing with monthly research meetings, annual symposia, career workshops, ethics training, CMBP-specific courses, optional internship programs, annual evaluations, and career monitoring, CMBP trainees will experience training not available through other programs. Special CMBP features also include the requirement for a co- advisor, who will provide expertise complementary to that of the advisor on a routine basis, and a mandatory scientific writing workshop specifically developed for this program. CMBP will be a rigorous and demanding program designed to attract top students to OSU, and the breadth and depth of the training provided will position CMBP graduates to make significant contributions to biomedical research in academia, government, and industry. In the past few years, significant institutional support, together with a new Arts and Sciences College structure, has facilitated interdisciplinary research and graduate training at OSU. Thus, we feel the time is right to bring these opportunities to a new level. The resources requested in this proposal would now allow us to build on existing strengths to develop a new graduate training program that spans a broad range of topics and activities in the cellular, biochemical and molecular sciences. The unique combination of opportunities offered through the CMBP will also increase recruitment and retention of the very best graduate students, in particular from underrepresented minorities (URM), thereby building upon recent successes in similar undergraduate recruitment activities at OSU. Matching institutional support towards our goal of having one quarter of new fellowships awarded to URM students each year has been secured.

Public Health Relevance

We seek to establish a new and unique graduate training opportunity at Ohio State University (OSU), the Cellular, Molecular and Biochemical Sciences Program (CMBP). This program will involve 35 faculty trainers from five related molecular life sciences graduate programs who represent the highest standards of excellence at OSU. The goal of the CMBP is to create new opportunities for student training by introducing career- advancing components, and the breadth and depth of the training provided will position CMBP graduates to make significant contributions to biomedical research in academia, government, and industry.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM086252-03
Application #
8496823
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
2011-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$151,514
Indirect Cost
$8,490
Name
Ohio State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Mohler, Kyle; Mann, Rebecca; Ibba, Michael (2017) Isoacceptor specific characterization of tRNA aminoacylation and misacylation in vivo. Methods 113:127-131
Mohler, Kyle; Aerni, Hans-Rudolf; Gassaway, Brandon et al. (2017) MS-READ: Quantitative measurement of amino acid incorporation. Biochim Biophys Acta 1861:3081-3088
Mohler, Kyle; Mann, Rebecca; Kyle, Amanda et al. (2017) Aminoacyl-tRNA quality control is required for efficient activation of the TOR pathway regulator Gln3p. RNA Biol :1-10
Hummels, Katherine R; Witzky, Anne; Rajkovic, Andrei et al. (2017) Carbonyl reduction by YmfI in Bacillus subtilis prevents accumulation of an inhibitory EF-P modification state. Mol Microbiol 106:236-251
Martinez, German; Choudury, Sarah G; Slotkin, R Keith (2017) tRNA-derived small RNAs target transposable element transcripts. Nucleic Acids Res 45:5142-5152
Song, Yunke; Kilburn, Duncan; Song, Jee Hoon et al. (2017) Determination of absolute expression profiles using multiplexed miRNA analysis. PLoS One 12:e0180988
Miller, Effie K; Trivelas, Nicholas E; Maugeri, Pearson T et al. (2017) Time-Resolved Investigations of Heterobimetallic Cofactor Assembly in R2lox Reveal Distinct Mn/Fe Intermediates. Biochemistry 56:3369-3379
Slater, Jeffrey W; Marguet, Sean C; Cirino, Sabrina L et al. (2017) Experimental and DFT Investigations Reveal the Influence of the Outer Coordination Sphere on the Vibrational Spectra of Nickel-Substituted Rubredoxin, a Model Hydrogenase Enzyme. Inorg Chem 56:3926-3938
Fultz, Dalen; Slotkin, R Keith (2017) Exogenous Transposable Elements Circumvent Identity-Based Silencing, Permitting the Dissection of Expression-Dependent Silencing. Plant Cell 29:360-376
Mohler, Kyle; Mann, Rebecca; Bullwinkle, Tammy J et al. (2017) Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae. Nucleic Acids Res 45:3985-3996

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