This competitive renewal application (5T32GM086270) seeks funding for years 6-10 of our successful T32 postdoctoral training program in anesthesiology and perioperative medicine research training at the University of Washington. Our primary objective is to provide in-depth research training at the postdoctoral level in cutting edge (and emerging) areas of biomedical science related to anesthesiology and perioperative medicine. Trainees from our first funding cycle have demonstrated success in this program, producing numerous peer- reviewed publications, achieving research honors and awards, attaining seed and startup grant funding, and presenting at scientific conferences. Reflecting the unique interdisciplinary composition of our department faculty and our educational mission, an important expansion of our training program is to provide interprofessional education to M.D. and Ph.D. clinician-scientists. We propose training six fellows per year who will spend 2-3 years cumulative time in research in one of a variety of laboratories in the Department of Anesthesiology and Pain Medicine or in collaborating basic science and clinical departments (e.g., Pharmacology, Genetics, Pediatrics, Psychiatry, Bioethics). Research opportunities are offered by 60NIH- funded faculty mentors with proven records of success in the training of postdoctoral fellows, with diverse research programs ranging from laboratory-based science to translational, clinical, and health services research. Core faculty research leaders will help match trainees to mentors within six major research areas relevant to anesthesiology and perioperative medicine including (alphabetically): 1) cardiovascular-pulmonary biology, 2) clinical outcomes research & epidemiology, 3) genome sciences & bioinformatics, 4) neurosciences, 5) pain, and 6) pharmacology.
Aims of the program are: to recruit outstanding diverse postdoctoral trainees from a national applicant pool; provide trainees with interdisciplinary theories and methods pertinent to their research area; provide trainees with the practical skills to design and conduct high quality research in anesthesiology and perioperative medicine (including fundamental research skills, understanding responsible conduct of research, ability to disseminate research findings, and acquire successful grantsmanship skills and independent funding); and to create a supportive environment through strong mentorship, a breadth of research opportunities, and collaboration across departments. Trainee progress is monitored regularly by an individualized fellow-specific review committee with summary findings reported to the departmental training grant advisory committee responsible for accepting/hiring fellows and following their progress. In addition, an external scientific oversight board meets yearly to offer advice to the program directors on all aspects of the training program. The overall intent of the program is to develop the next generation of clinician scientist leaders in anesthesiology and perioperative medicine research.

Public Health Relevance

A crucial need exists for anesthesiology and perioperative medicine investigators with a broad range of theoretical, methodological, and technical knowledge. These attributes are required to advance scientific opportunities from basic, behavioral, population and clinical sciences to novel applications that reduce the burden placed on patients and their families by pain, stress, and perioperative complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM086270-10
Application #
9476999
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Cole, Alison E
Project Start
2009-07-01
Project End
2019-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
10
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Washington
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Law, Emily F; Wan Tham, See; Aaron, Rachel V et al. (2018) Hybrid Cognitive-Behavioral Therapy Intervention for Adolescents With Co-Occurring Migraine and Insomnia: A Single-Arm Pilot Trial. Headache 58:1060-1073
El Bcheraoui, Charbel; Kamath, Aruna M; Dansereau, Emily et al. (2018) Results-based aid with lasting effects: sustainability in the Salud Mesoamérica Initiative. Global Health 14:97
Aaron, Rachel V; Snodgress, Matthew A; Blain, Scott D et al. (2018) Affect labeling and other aspects of emotional experiences in relation to alexithymia following standardized emotion inductions. Psychiatry Res 262:115-123
Rabbitts, Jennifer A; Aaron, Rachel V; Fisher, Emma et al. (2017) Long-Term Pain and Recovery After Major Pediatric Surgery: A Qualitative Study With Teens, Parents, and Perioperative Care Providers. J Pain 18:778-786
Krishnamoorthy, Vijay; Chaikittisilpa, Nophanan; Kiatchai, Taniga et al. (2017) Hypertension After Severe Traumatic Brain Injury: Friend or Foe? J Neurosurg Anesthesiol 29:382-387
Groenewald, Cornelius B; Beals-Erickson, Sarah E; Ralston-Wilson, Jaime et al. (2017) Complementary and Alternative Medicine Use by Children With Pain in the United States. Acad Pediatr 17:785-793
Krishnamoorthy, Vijay; Rowhani-Rahbar, Ali; Chaikittisilpa, Nophanan et al. (2017) Association of Early Hemodynamic Profile and the Development of Systolic Dysfunction Following Traumatic Brain Injury. Neurocrit Care 26:379-387
Rabbitts, Jennifer A; Aaron, Rachel V; Zempsky, William T et al. (2017) Validation of the Youth Acute Pain Functional Ability Questionnaire in Children and Adolescents Undergoing Inpatient Surgery. J Pain 18:1209-1215
Khandelwal, Nita; Curtis, J Randall; Freedman, Vicki A et al. (2017) How Often Is End-of-Life Care in the United States Inconsistent with Patients' Goals of Care? J Palliat Med 20:1400-1404
Krishnamoorthy, Vijay; Rowhani-Rahbar, Ali; Gibbons, Edward F et al. (2017) Early Systolic Dysfunction Following Traumatic Brain Injury: A Cohort Study. Crit Care Med 45:1028-1036

Showing the most recent 10 out of 64 publications