The practice of Anesthesia is rapidly expanding beyond the boundaries of the operating room. Increasingly, anesthesiologists are taking a roles is critical care, the management of pain, rapid response to inpatient emergencies, in addition to clinical and basic science research. Rapidly changing healthcare environments require that the next generation of leaders in anesthesia be broadly trained, both clinically and in basic and translational science. The goals of this post-doctoral training program are to provide young scientists with outstanding experiences in basic and translational research arenas. The primary focus of the program will be to train the next generation of physician scholars (those having MD or MD/PhD degrees). This program will fund 2 fellows per year for 2 years, meaning 4 funded slots per year. We envision four tracks for research training, each of which will draw on outstanding expertise at Yale, both within the Department of Anesthesia, and in other programs in the Medical Center and the University. The Vascular Biology track will leverage trainers within Anesthesia, in conjunction with the well-established and interdisciplinary Vascular Biology and Therapeutics (VBT) program at Yale. The Biology of Inflammation/Immunity track will involve trainers from the Department of Immunobiology and from the Human Translational Immunology, both of which include world-class investigators. The Bioengineering track will include investigators from Anesthesia, as well as the Bioengineering Department and outstanding groups in Diagnostic Imaging. The fourth track, Clinical Research, will also leverage training resources within the Department, as well as the recently-awarded CTSA program at Yale. To further advance the training of physician scientists, and independent of this T32 application, we have recently established a Resident Scholars Program (RSP). The RSP is funded entirely by the Anesthesia department, and provides intensive mentoring in research during the 3 years of anesthesia residency. We anticipate that many of these highly select residents in the RSP will be excellent candidates for enrollment in this T32 post-doctoral training program upon completion of their residency.

Public Health Relevance

This grant will fund advanced research training for clinical anesthesiologists, in both basic science and in clinically oriented research. By providing outstanding training to practicing physicians, we are improving the delivery and advancement of healthcare nationwide, because these trained physicians will drive the development of new therapies and improved ways of caring for patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM086287-05
Application #
8500360
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Cole, Alison E
Project Start
2009-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$108,003
Indirect Cost
$14,248
Name
Yale University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Schonberger, Robert B; Lampert, Rachel J; Mandel, Ernest I et al. (2014) Handheld Doppler to improve pulse checks during resuscitation of putative pulseless electrical activity arrest. Anesthesiology 120:1042-5
Gipson, Keith E; Rosinski, David J; Schonberger, Robert B et al. (2014) Elimination of gaseous microemboli from cardiopulmonary bypass using hypobaric oxygenation. Ann Thorac Surg 97:879-86
Schonberger, Robert B; Gilbertsen, Todd; Dai, Feng (2014) The problem of controlling for imperfectly measured confounders on dissimilar populations: a database simulation study. J Cardiothorac Vasc Anesth 28:247-54
Mendez, Julio J; Ghaedi, Mahboobe; Steinbacher, Derek et al. (2014) Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds. Tissue Eng Part A 20:1735-46
Schonberger, Robert B; Feinleib, Jessica; Holt, Natalie et al. (2014) Preoperative depression symptom severity and its impact on adherence to preoperative beta-blocker therapy. J Cardiothorac Vasc Anesth 28:1467-73
Tsuchiya, Tomoshi; Balestrini, Jenna L; Mendez, Julio et al. (2014) Influence of pH on extracellular matrix preservation during lung decellularization. Tissue Eng Part C Methods 20:1028-36
Safavi, Kyan C; Dai, Feng; Gilbertsen, Todd A et al. (2014) Variation in surgical quality measure adherence within hospital referral regions: do publicly reported surgical quality measures distinguish among hospitals that patients are likely to compare? Health Serv Res 49:1108-20
Ghaedi, Mahboobe; Mendez, Julio J; Bove, Peter F et al. (2014) Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor. Biomaterials 35:699-710
Ghaedi, Mahboobe; Calle, Elizabeth A; Mendez, Julio J et al. (2013) Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix. J Clin Invest 123:4950-62
Schonberger, Robert B; Barash, Paul G (2013) They did what ... ? Anesth Analg 117:3-5

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