This application seeks to renew support for our graduate training program in Molecular Biophysics. This program includes 21 faculty from eight departments and two schools at New York University, namely the School of Medicine and the Faculty of Arts and Sciences. These faculty work on a wide array of topics in an attempt to derive fundamental understanding of the molecular mechanisms driving biological processes such as growth factor signaling, immunity, membrane transport, and gene transcription. Features of this program that make it unique at NYU is the focus on biophysical research tools and the quantitative background of students attracted to the program. Specifically, our faculty employ biophysical approaches such as X-ray crystallography, NMR, electron microscopy, single-molecule fluorescence microscopy, mass spectrometry, and computational methods, generally in combination with conventional approaches of biochemistry, molecular biology and genetics. Ph.D. level training in this area is important in maintaining the competitive edge of thi country in quantitative sciences and the position we have held as leaders in technological and medical innovation over the last half century. Our faculty have been highly productive with almost 300 publications in the last four years. Frequent collaborations amongst these faculty is evidenced by 20 publications with two or more authors from our program as well as a history of co-mentorship of students. Over the last ten years, 88% of student matriculating in our program have succeeded in obtained Ph.D. degrees (23 out of 26). These include 15 students who have graduated during the past 4 years with training grant support. Over this same 4- year period our students have coauthored 46 publications and served as first author on 26 of these. Currently, fourteen students are enrolled in the program with four new students due to join in August of 2014, reflecting consecutive years of successful recruitment in a very competitive academic market of the northeastern US. We have a good record in recruiting students from under-represented minorities or disadvantaged backgrounds over the life of the program, with 6 out of 41 students (15%) coming from this group; all of these students have so far have succeeded in obtained Ph.D. degrees. Our training program combines early didactic course work, strong mentorship from program advisors and thesis committees, research opportunities that start with research rotations and conclude with four years of thesis research designed to prepare students for independent careers in biomedical science. Throughout this period, students are given regular opportunities to present their work in a variety of venues ranging from bi-weekly program meetings to national meetings. The program also includes career development training and internship opportunities. Career outcome for our graduates have been excellent, with two faculty members at universities, two group leaders at pharmaceutical companies, and all the rest in intermediate science related careers either as postdoctoral fellows or industrial scientists.

Public Health Relevance

Mechanistic information about biological macromolecules represents key information for developing therapies to combat the cause and spread of disease. This application seeks to renew a Ph.D. training program to teach scientists how to obtain such information and to prepare them for scientific careers in academia, industry, government and education.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM088118-08
Application #
9319772
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Flicker, Paula F
Project Start
2010-07-01
Project End
2020-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
8
Fiscal Year
2017
Total Cost
Indirect Cost
Name
New York University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10010
Peselis, Alla; Serganov, Alexander (2018) ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands. Nat Chem Biol 14:887-894
Huang, Ching-Shin; Pedersen, Bjørn Panyella; Stokes, David L (2017) Crystal structure of the potassium-importing KdpFABC membrane complex. Nature 546:681-685
Weiss, Sarah A; Han, Joseph; Darvishian, Farbod et al. (2016) Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts. J Transl Med 14:299
Vogelsang, Matjaz; Martinez, Carlos N; Rendleman, Justin et al. (2016) The Expression Quantitative Trait Loci in Immune Pathways and their Effect on Cutaneous Melanoma Prognosis. Clin Cancer Res 22:3268-80
Ruggles, Kelly V; Tang, Zuojian; Wang, Xuya et al. (2016) An Analysis of the Sensitivity of Proteogenomic Mapping of Somatic Mutations and Novel Splicing Events in Cancer. Mol Cell Proteomics 15:1060-71
Sisirak, Vanja; Sally, Benjamin; D'Agati, Vivette et al. (2016) Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity. Cell 166:88-101
Peselis, Alla; Gao, Ang; Serganov, Alexander (2016) Preparation and Crystallization of Riboswitches. Methods Mol Biol 1320:21-36
James, Tamara D; Cardozo, Timothy; Abell, Lauren E et al. (2016) Visualizing the phage T4 activated transcription complex of DNA and E. coli RNA polymerase. Nucleic Acids Res 44:7974-88
Bode, Nadine J; Chan, Kun-Wei; Kong, Xiang-Peng et al. (2016) Distinct Residues Contribute to Motility Repression and Autoregulation in the Proteus mirabilis Fimbria-Associated Transcriptional Regulator AtfJ. J Bacteriol 198:2100-12
Reid, Dylan A; Keegan, Sarah; Leo-Macias, Alejandra et al. (2015) Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair. Proc Natl Acad Sci U S A 112:E2575-84

Showing the most recent 10 out of 43 publications