This proposal requests funding for the predoctoral Chemical Biology Training Program at Stony Brook University (SBU). This interdisciplinary and interdepartmental Program offers chemical biology training opportunities for Ph.D. students selected from four participating units: the Biochemistry &Structural Biology, the Chemistry, the Molecular Genetics &Microbiology, and the Molecular &Cellular Pharmacology graduate programs. Participating faculty mentors (29) have research interests in infectious disease, cancer and toxicology, immunology, developmental biology, energy-harvesting, cell-signaling, organic synthesis, physical organic chemistry, enzymology, and materials chemistry. Trainees are educated in the principles and techniques of both chemistry and biology with a core interdisciplinary three-semester Chemical Biology course sequence. All trainees and mentors participate in the Institute of Chemical Biology and Drug Discovery annual symposium and poster session. This retreat is one avenue by which extensive interactions between students and faculty are fostered and the trainee group maintains a cohesive identity. The students meet for lunch with a Program Director or Mentor once per month during the academic year as a forum for feedback on careers, program assessment and two-way feedback. Trainees participate in their home graduate program research clubs and seminar series to broaden their knowledge and networking opportunities beyond the training program. In their fourth year, trainees work with Journalism faculty to convert their previously prepared research talks to presentations that non-scientists can understand and appreciate with the most compelling to be presented in a community outreach forum. Trainees invite outside seminar speakers. Instruction in the responsible conduct of research is carried out primarily through participation the course, """"""""Scientific Integrity"""""""". Recruitment of underrepresented groups is achieved through the SBU AGEP summer undergraduate research programs and extensive outreach. The number of mentors participating in the CBI Training Program is 29 and four funded positions are requested in the first year and eight funded positions are requested in subsequent years.

Public Health Relevance

Training of graduate students is essential for present and future discovery in biomedical research spanning cancer chemotherapy to new anti-infectives. This training program will provide students with training in chemical methods and biological methods that is necessary for developing new and better diagnostics and treatments for disease.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Fabian, Miles
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
State University New York Stony Brook
Schools of Arts and Sciences
Stony Brook
United States
Zip Code
Hauser, Kevin; Essuman, Bernard; He, Yiqing et al. (2016) A human transcription factor in search mode. Nucleic Acids Res 44:63-74
Lee, Katarzyna N; Lei, Zhen; Morales-Rivera, Cristian A et al. (2016) Mechanistic studies on intramolecular C-H trifluoromethoxylation of (hetero)arenes via OCF3-migration. Org Biomol Chem 14:5599-605
Feng, Pengju; Lee, Katarzyna N; Lee, Johnny W et al. (2016) Access to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines. Chem Sci 7:424-429
Neckles, Carla; Pschibul, Annica; Lai, Cheng-Tsung et al. (2016) Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase. Biochemistry 55:2992-3006
Shah, Lisa; Laughlin, Scott T; Carrico, Isaac S (2016) Light-Activated Staudinger-Bertozzi Ligation within Living Animals. J Am Chem Soc 138:5186-9
Lee, Katarzyna N; Lee, Johnny W; Ngai, Ming-Yu (2016) Synthesis of Trifluoromethoxylated (Hetero)Arenes via OCF3 Migration. Synlett 27:313-319
Gil, Agnieszka A; Haigney, Allison; Laptenok, Sergey P et al. (2016) Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: Effect of the Y21 pKa on the Forward and Reverse Ground-State Reactions. J Am Chem Soc 138:926-35
Nisbett, Lisa-Marie; Boon, Elizabeth M (2016) Nitric Oxide Regulation of H-NOX Signaling Pathways in Bacteria. Biochemistry 55:4873-84
Akter, Rehana; Cao, Ping; Noor, Harris et al. (2016) Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology. J Diabetes Res 2016:2798269
Daryaee, Fereidoon; Chang, Andrew; Schiebel, Johannes et al. (2016) Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase. Chem Sci 7:5945-5954

Showing the most recent 10 out of 37 publications