This proposal requests funding for the predoctoral Chemical Biology Training Program at Stony Brook University (SBU). This interdisciplinary and interdepartmental Program offers chemical biology training opportunities for Ph.D. students selected from four participating units: the Biochemistry &Structural Biology, the Chemistry, the Molecular Genetics &Microbiology, and the Molecular &Cellular Pharmacology graduate programs. Participating faculty mentors (29) have research interests in infectious disease, cancer and toxicology, immunology, developmental biology, energy-harvesting, cell-signaling, organic synthesis, physical organic chemistry, enzymology, and materials chemistry. Trainees are educated in the principles and techniques of both chemistry and biology with a core interdisciplinary three-semester Chemical Biology course sequence. All trainees and mentors participate in the Institute of Chemical Biology and Drug Discovery annual symposium and poster session. This retreat is one avenue by which extensive interactions between students and faculty are fostered and the trainee group maintains a cohesive identity. The students meet for lunch with a Program Director or Mentor once per month during the academic year as a forum for feedback on careers, program assessment and two-way feedback. Trainees participate in their home graduate program research clubs and seminar series to broaden their knowledge and networking opportunities beyond the training program. In their fourth year, trainees work with Journalism faculty to convert their previously prepared research talks to presentations that non-scientists can understand and appreciate with the most compelling to be presented in a community outreach forum. Trainees invite outside seminar speakers. Instruction in the responsible conduct of research is carried out primarily through participation the course, """"""""Scientific Integrity"""""""". Recruitment of underrepresented groups is achieved through the SBU AGEP summer undergraduate research programs and extensive outreach. The number of mentors participating in the CBI Training Program is 29 and four funded positions are requested in the first year and eight funded positions are requested in subsequent years.

Public Health Relevance

Training of graduate students is essential for present and future discovery in biomedical research spanning cancer chemotherapy to new anti-infectives. This training program will provide students with training in chemical methods and biological methods that is necessary for developing new and better diagnostics and treatments for disease.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Fabian, Miles
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State University New York Stony Brook
Schools of Arts and Sciences
Stony Brook
United States
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Bacon, Bezalel; Nisbett, Lisa-Marie; Boon, Elizabeth (2017) Bacterial Haemoprotein Sensors of NO: H-NOX and NosP. Adv Microb Physiol 70:1-36
Lee, Katarzyna N; Lei, Zhen; Ngai, Ming-Yu (2017) ?-Selective Reductive Coupling of Alkenylpyridines with Aldehydes and Imines via Synergistic Lewis Acid/Photoredox Catalysis. J Am Chem Soc :
Hossain, Sajjad; Nisbett, Lisa-Marie; Boon, Elizabeth M (2017) Discovery of Two Bacterial Nitric Oxide-Responsive Proteins and Their Roles in Bacterial Biofilm Regulation. Acc Chem Res 50:1633-1639
Alford, Vincent M; Kamath, Anushree; Ren, Xiaodong et al. (2017) Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions. ACS Chem Biol 12:2788-2803
Williams, Dominique E; Nisbett, Lisa-Marie; Bacon, Bezalel et al. (2017) Bacterial Heme-Based Sensors of Nitric Oxide. Antioxid Redox Signal :
Delle Bovi, Richard J; Miller, W Todd (2017) Expression and purification of functional insulin and insulin-like growth factor 1 holoreceptors from mammalian cells. Anal Biochem 536:69-77
Neckles, Carla; Eltschkner, Sandra; Cummings, Jason E et al. (2017) Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase. Biochemistry 56:1865-1878
Hauser, Kevin; He, Yiqing; Garcia-Diaz, Miguel et al. (2017) Characterization of Biomolecular Helices and Their Complementarity Using Geometric Analysis. J Chem Inf Model 57:864-874
Gil, Agnieszka A; Laptenok, Sergey P; Iuliano, James N et al. (2017) Photoactivation of the BLUF Protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues. J Am Chem Soc 139:14638-14648
Gil, Agnieszka A; Laptenok, Sergey P; French, Jarrod B et al. (2017) Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain. J Phys Chem B 121:1010-1019

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