This initial submission for an institutional training grant is aimed at providing research training for postdoctoral trainees who will pursue careers related to critical care. The training program will be jointly based in the newly formed Emory Center for Critical Care and in the Department of Surgery at the Emory University School of Medicine. It will be multidisciplinary in nature, with faculty from the Departments of Surgery, Medicine, Pediatrics, and Biochemistry participating in the training program. The training program is two years of length, and all applicants must have a graduate level degree (MD, PhD or equivalent). The philosophy of this training program is translational science founded upon strong collaborations among clinicians and investigators. The program director/principal investigator is Craig Coopersmith, Professor of Surgery at Emory University and the Associate Director of the Emory Center for Critical Care. The PI/PD will interface closely with an executive committee made up of Timothy Buchman, PhD, MD (Professor of Surgery, Director Emory Center for Critical Care), Thomas Ziegler, MD (Professor of Medicine, Co-Program Director, Research Education, Training and Career Development Core, Atlanta Clinical and Translational Science Institute) and Greg Martin, MD (Associate Professor of Medicine, Associate Division Director for Critical Care, Pulmonary, Allergy and Critical Care). The program has 8 additional mentors from multiple departments, with widely varying research interests in domains related to critical care ranging from oxidative stress to acute lung injury to implementation science in the intensive care unit. The program has been designed to mimic the broad scope of critical care by giving trainees access to mentors with expertise in basic science, translational and clinical research. There are opportunities that span the entire age range of critical illness - from neonates to geriatrics. To provide a diverse set of opportunities, mentors are based at the following-types of hospitals in the Atlanta area - academic (Emory University Hospital), community (Emory University Hospital Midtown), public (Grady Memorial Hospital), federally-funded (Atlanta Veterans Affairs Medical Center), and children's (Children's Hospital of Atlanta at Egleston). Ultimately, the research training program is designed to reflect the collaborative and interdisciplinary nature of clinical critical care and to develop independent researchers dedicated to improving the outcomes of patients in the intensive care unit.

Public Health Relevance

As the population ages, more and more patients are cared for in intensive care units. However, there is a growing gap between the rapidly expanding need for critical care services and both the workforce needed to take care of critically ill patients and the researchers needed to discover new insights to improve outcomes in the intensive care unit. This institutional training grant is aimed at bridging this gap by providing research training for individuals who will pursue careers related to critical care.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZGM1)
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Somers, Scott D
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Emory University
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United States
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Lyons, John D; Ford, Mandy L; Coopersmith, Craig M (2016) The Microbiome in Critical Illness: Firm Conclusions or Bact to Square One? Dig Dis Sci 61:1420-1
Klingensmith, Nathan J; Yoseph, Benyam P; Liang, Zhe et al. (2016) Epidermal Growth Factor Improves Intestinal Integrity and Survival in Murine Sepsis Following Chronic Alcohol Ingestion. Shock :
Polito, Carmen C; Sevransky, Jonathan E; Dickert, Neal W (2016) Ethical and regulatory challenges in advancing prehospital research: focus on sepsis. Am J Emerg Med 34:623-5
Grunwell, Jocelyn R; Marupudi, Neelima K; Gupta, Rohan V et al. (2016) Outcomes following implementation of a pediatric procedural sedation guide for referral to general anesthesia for magnetic resonance imaging studies. Paediatr Anaesth 26:628-36
Yoseph, Benyam P; Klingensmith, Nathan J; Liang, Zhe et al. (2016) Mechanisms of Intestinal Barrier Dysfunction in Sepsis. Shock 46:52-9
Klingensmith, Nathan J; Coopersmith, Craig M (2016) The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness. Crit Care Clin 32:203-12
Grunwell, Jocelyn R; Travers, Curtis; McCracken, Courtney E et al. (2016) Procedural Sedation Outside of the Operating Room Using Ketamine in 22,645 Children: A Report From the Pediatric Sedation Research Consortium. Pediatr Crit Care Med 17:1109-1116
Margoles, Lindsay M; Mittal, Rohit; Klingensmith, Nathan J et al. (2016) Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis. PLoS One 11:e0165886
Lyons, John D; Mittal, Rohit; Fay, Katherine T et al. (2016) Murine Lung Cancer Increases CD4+ T Cell Apoptosis and Decreases Gut Proliferative Capacity in Sepsis. PLoS One 11:e0149069
Ogbu, Ogbonna C; Murphy, David J; Martin, Greg S (2015) How to avoid fluid overload. Curr Opin Crit Care 21:315-21

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