Support is requested to establish a predoctoral training program in Chemical and Structural Biology (CSB) at the University of California, Irvine (UCI). Over the past several years, UCI has hired faculty in Chemical Biology, which now is recognized here at UCI and elsewhere as a formal subdiscipline in Chemistry. Parallel to the growth in Chemical Biology has been substantial growth in Structural Biology, which includes protein crystallography, NMR spectroscopy, and computational biology. Several of the training faculty associated with this proposed program are located in the relatively new (10 years old) Natural Sciences 1 and nearby Natural Sciences 2 buildings. This, together with the open lab environment present in these buildings, has substantially increased interactions between students, postdocs, and faculty, fostering new and productive collaborations. The direct outcome of this parallel growth in Chemical and Structural Biology has been substantial changes in the UCI Chao Comprehensive Cancer Center. Early on, Prof. Poulos was Director of the Structural Molecular Biology Program in the Cancer Center. Over the years, however, more chemists joined the Cancer Center and it became apparent that the scope of research in the Structural and Molecular Biology Program no longer was limited to structural biology. It thus was decided to change the name and membership of the Program and bring in a Co-Director, Prof. Weiss, who represents the Dept. of Chemistry. This reorganization substantially increased collaborative efforts between Chemists and Biologists and resulted in several joint appointments. In addition, more and more graduate students were attracted to UCI's Chemical and Structural Biology Programs. This further resulted in the development of new courses that are taught primarily by Chemical and Structural Biologists. In effect, UCI already has a partially developed program in Chemical and Structural Biology and the purpose of this training grant is to formalize this program to continue to provide specific training at the Chemistry/Biology interface and to provide predoctoral students interested in Chemical and Structural Biology research with a formal training environment. This training grant will provide support for up to seven predoctoral trainees per year (with a 25% match from UCI's Graduate Division), starting in their second year, and offering continuous support for up to three years. Given the strength of structural biology here at UCI, and the many existing collaborations between chemists and structural biologists, we believe that a training program in CSB would best match our strengths. Additionally, many of our training faculty have collaborations throughout UCI, which include immunologists, engineers, cancer biologists, virologists, etc. Therefore, students in the CSB Program will not only have opportunities to interact with other CSB interested individuals, but the opportunity to interact with UCI research groups not specifically focused on chemistry or structural biology across campus.
The rapid development of Chemical Biology as a subdiscipline in Chemistry has dramatically increased cross disciplinary research between Biologists and Chemists. It is critically important that academic institutions train the next generation of Chemical Biologists to fulfill the growing needs in both academia and industry. UCI already has developed an exceptional Chemical and Structural Biology Program within the UCI Chao Comprehensive and Cancer Center, which has provided the basis for this proposal to specifically focus graduate training at the crossroads of Chemistry and Biology.
|Hollingsworth, Scott A; Nguyen, Brian D; Chreifi, Georges et al. (2017) Insights into the Dynamics and Dissociation Mechanism of a Protein Redox Complex Using Molecular Dynamics. J Chem Inf Model 57:2344-2350|
|Hollingsworth, Scott A; Batabyal, Dipanwita; Nguyen, Brian D et al. (2016) Conformational selectivity in cytochrome P450 redox partner interactions. Proc Natl Acad Sci U S A 113:8723-8|
|Salveson, Patrick J; Spencer, Ryan K; Nowick, James S (2016) X-ray Crystallographic Structure of Oligomers Formed by a Toxic ?-Hairpin Derived from ?-Synuclein: Trimers and Higher-Order Oligomers. J Am Chem Soc 138:4458-67|
|Gutierrez, Craig B; Yu, Clinton; Novitsky, Eric J et al. (2016) Developing an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein-Protein Interactions. Anal Chem 88:8315-22|
|Hollingsworth, Scott A; Holden, Jeffrey K; Li, Huiying et al. (2016) Elucidating nitric oxide synthase domain interactions by molecular dynamics. Protein Sci 25:374-82|
|Nazarova, Lidia A; Ochoa, Roxanna J; Jones, Krysten A et al. (2016) Extracellular Toxoplasma gondii tachyzoites metabolize and incorporate unnatural sugars into cellular proteins. Microbes Infect 18:199-210|
|O'Brien, Jeffrey; Shea, Kenneth J (2016) Tuning the Protein Corona of Hydrogel Nanoparticles: The Synthesis of Abiotic Protein and Peptide Affinity Reagents. Acc Chem Res 49:1200-10|
|Chreifi, Georges; Hollingsworth, Scott A; Li, Huiying et al. (2015) Enzymatic Mechanism of Leishmania major Peroxidase and the Critical Role of Specific Ionic Interactions. Biochemistry 54:3328-36|
|Astashkin, Andrei V; Chen, Li; Elmore, Bradley O et al. (2015) Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance. J Phys Chem A 119:6641-9|
|Holden, Jeffrey K; Kang, Soosung; Hollingsworth, Scott A et al. (2015) Structure-based design of bacterial nitric oxide synthase inhibitors. J Med Chem 58:994-1004|
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