The primary goal of this training program is to provide multidisciplinary predoctoral and postdoctoral training in reproductive biology for those who wish to pursue an academic career in research and teaching in this area of biological science. This application requests funds to continue a training grant which has been funded for the past 30 years. Trainees will be selected based on their academic merit and potential for a productive research career in reproductive biology. The training faculty have expertise in many areas of reproductive biology including: neuroendocrine regulation of sexual development and mature reproductive function, hormonal control of the pituitary, the molecular biology of GnRH action, endocrine and paracrine control of gonadal function, regulation of the reproductive tract, and identification of genes involved in ovarian function and early embryogenesis. Many of the training faculty have a strong molecular orientation, and virtually all use molecular techniques into their research. Predoctoral students will be trained in one of three graduate programs at the Oregon Health and Science University: the Program in Molecular and Cellular Biosciences, the Dept. of Behavioral Neuroscience, or the Neuroscience Graduate Program. They will meet the course, seminar, and laboratory research requirements of the graduate council of OHSU and the specific requirements of the program in which they are training. Postdoctoral fellows will have access to the same courses and seminars, but emphasis will be placed on laboratory research. The unique features of this training program reside in the roster of faculty who study a wide range of areas within reproductive biology;the close ties between the research laboratories within the training program which facilitate co-mentoring of students;free access by students to expertise and equipment in all of the laboratories of the training program;regular meetings of journal clubs and research discussion groups;and the accessibility of performing reproductive research with nonhuman primates at the Oregon National Primate Research Center, and the presence of a number of collaborative interactions that include clinicians and basic scientists interested in reproductive biology. Programs for recruitment of minority trainees and formal instruction in the principles of scientific conduct and practice are in place.

Public Health Relevance

This grant application is to continue training pre- and postdoctoral fellows in reproductive biology. Strengths of the 30-year program include faculty with expertise in a wide range of areas in reproductive biology, strong interdisciplinary links between labs, the ability to work with nonhuman primate models and undertake translational research, and a number of collaborative centers encompassing reproductive biology research.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007133-35
Application #
8657459
Study Section
Developmental Biology Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1978-07-01
Project End
2015-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
35
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97239
Bishop, Cecily V; Xu, Fuhua; Xu, Jing et al. (2016) Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys. Fertil Steril 105:1023-34
Daughtry, Brittany L; Chavez, Shawn L (2016) Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences. Cell Tissue Res 363:201-25
Nestor, Casey C; Qiu, Jian; Padilla, Stephanie L et al. (2016) Optogenetic Stimulation of Arcuate Nucleus Kiss1 Neurons Reveals a Steroid-Dependent Glutamatergic Input to POMC and AgRP Neurons in Male Mice. Mol Endocrinol 30:630-44
Lomniczi, Alejandro; Wright, Hollis; Castellano, Juan Manuel et al. (2015) Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression. Nat Commun 6:10195
Rønnekleiv, Oline K; Fang, Yuan; Zhang, Chunguang et al. (2014) Research resource: Gene profiling of G protein-coupled receptors in the arcuate nucleus of the female. Mol Endocrinol 28:1362-80
Daughtry, Brittany; Mitalipov, Shoukhrat (2014) Concise review: parthenote stem cells for regenerative medicine: genetic, epigenetic, and developmental features. Stem Cells Transl Med 3:290-8
Castellano, Juan Manuel; Wright, Hollis; Ojeda, Sergio R et al. (2014) An alternative transcription start site yields estrogen-unresponsive Kiss1 mRNA transcripts in the hypothalamus of prepubertal female rats. Neuroendocrinology 99:94-107
Jensen, Jeffrey T; Hanna, Carol; Yao, Shan et al. (2014) Blockade of tubal patency following transcervical administration of polidocanol foam: initial studies in rhesus macaques. Contraception 89:540-9
Qiu, Jian; Zhang, Chunguang; Borgquist, Amanda et al. (2014) Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels. Cell Metab 19:682-93
McGee, W K; Bishop, C V; Pohl, C R et al. (2014) Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys. Am J Physiol Endocrinol Metab 306:E1292-304

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