The primary goal of this training program is to provide multidisciplinary predoctoral and postdoctoral training in reproductive biology for those who wish to pursue an academic career in research and teaching in this area of biological science. This application requests funds to continue a training grant which has been funded for the past 30 years. Trainees will be selected based on their academic merit and potential for a productive research career in reproductive biology. The training faculty have expertise in many areas of reproductive biology including: neuroendocrine regulation of sexual development and mature reproductive function, hormonal control of the pituitary, the molecular biology of GnRH action, endocrine and paracrine control of gonadal function, regulation of the reproductive tract, and identification of genes involved in ovarian function and early embryogenesis. Many of the training faculty have a strong molecular orientation, and virtually all use molecular techniques into their research. Predoctoral students will be trained in one of three graduate programs at the Oregon Health and Science University: the Program in Molecular and Cellular Biosciences, the Dept. of Behavioral Neuroscience, or the Neuroscience Graduate Program. They will meet the course, seminar, and laboratory research requirements of the graduate council of OHSU and the specific requirements of the program in which they are training. Postdoctoral fellows will have access to the same courses and seminars, but emphasis will be placed on laboratory research. The unique features of this training program reside in the roster of faculty who study a wide range of areas within reproductive biology;the close ties between the research laboratories within the training program which facilitate co-mentoring of students;free access by students to expertise and equipment in all of the laboratories of the training program;regular meetings of journal clubs and research discussion groups;and the accessibility of performing reproductive research with nonhuman primates at the Oregon National Primate Research Center, and the presence of a number of collaborative interactions that include clinicians and basic scientists interested in reproductive biology. Programs for recruitment of minority trainees and formal instruction in the principles of scientific conduct and practice are in place.

Public Health Relevance

This grant application is to continue training pre- and postdoctoral fellows in reproductive biology. Strengths of the 30-year program include faculty with expertise in a wide range of areas in reproductive biology, strong interdisciplinary links between labs, the ability to work with nonhuman primate models and undertake translational research, and a number of collaborative centers encompassing reproductive biology research.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Developmental Biology Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Schools of Medicine
United States
Zip Code
Castellano, Juan Manuel; Wright, Hollis; Ojeda, Sergio R et al. (2014) An alternative transcription start site yields estrogen-unresponsive Kiss1 mRNA transcripts in the hypothalamus of prepubertal female rats. Neuroendocrinology 99:94-107
Rønnekleiv, Oline K; Fang, Yuan; Zhang, Chunguang et al. (2014) Research resource: Gene profiling of G protein-coupled receptors in the arcuate nucleus of the female. Mol Endocrinol 28:1362-80
Jensen, Jeffrey T; Hanna, Carol; Yao, Shan et al. (2014) Blockade of tubal patency following transcervical administration of polidocanol foam: initial studies in rhesus macaques. Contraception 89:540-9
McGee, W K; Bishop, C V; Pohl, C R et al. (2014) Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys. Am J Physiol Endocrinol Metab 306:E1292-304
Qiu, Jian; Zhang, Chunguang; Borgquist, Amanda et al. (2014) Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels. Cell Metab 19:682-93
Daughtry, Brittany; Mitalipov, Shoukhrat (2014) Concise review: parthenote stem cells for regenerative medicine: genetic, epigenetic, and developmental features. Stem Cells Transl Med 3:290-8
Rivera, Heidi M; Bethea, Cynthia L (2013) Ovarian steroids increase PSD-95 expression and dendritic spines in the dorsal raphe of ovariectomized macaques. Synapse 67:897-908
Cukier, Priscilla; Wright, Hollis; Rulfs, Tomke et al. (2013) Molecular and gene network analysis of thyroid transcription factor 1 (TTF1) and enhanced at puberty (EAP1) genes in patients with GnRH-dependent pubertal disorders. Horm Res Paediatr 80:257-66
Kaufman, Katherine R; Kelly, Martin J; Roselli, Charles E (2013) Rapid effects of 17*-estradiol on male copulatory behaviors are not elicited by the novel membrane active estrogenic compound STX. Behav Neurosci 127:598-605
Sorwell, K G; Urbanski, H F (2013) Causes and consequences of age-related steroid hormone changes: insights gained from nonhuman primates. J Neuroendocrinol 25:1062-9

Showing the most recent 10 out of 79 publications