Continuing support is requested for the Yale Predoctoral Training Program in Human Genetics and Genomics. The program involves 44 trainers from 14 departments. The vast majority of trainers are primary and joint appointees in the Department of Genetics at the School of Medicine, and virtually all of the trainees over the last funding period have been matriculated in the Molecular, Cell Biology, Genetics &Development Track (MCGD) in Biological and Biomedical Sciences at Yale. The focus of the training proposed is the use of genetic and genomic approaches to understand human disease. The main methods used are positional cloning of human and mouse disease genes, complemented by bioinformatics and computational analysis, transgenic and knock-out methods in mouse as well as use of model organisms including Drosophila and C. elegans to define biochemical pathways and permit genetics screening for modifier loci. This integrated program bringing together faculty with diverse backgrounds and expertise provides a rich training environment for students. Admitted students have strong scientific backgrounds and research experience with high academic achievement. Training in the first year includes formal course work and research rotations, leading to selection of the thesis advisor's laboratory. In the second year students complete course work, and take a qualifying exam in which they must demonstrate mastery of genetics and defend two written research proposals. Subsequent years are devoted to dissertation research and preparation of the written thesis. In addition, students engage in supervised teaching experience. Support is requested for 7 graduate students per year for a five year period.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007149-33
Application #
7840406
Study Section
Special Emphasis Panel (ZHD1-RRG-K (32))
Program Officer
Vitkovic, Ljubisa
Project Start
1978-07-01
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
33
Fiscal Year
2010
Total Cost
$301,807
Indirect Cost
Name
Yale University
Department
Genetics
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Sondalle, Samuel B; Baserga, Susan J (2017) Ribosomes Need Straight A's to Sleep. Cell 169:565-567
Yartseva, Valeria; Takacs, Carter M; Vejnar, Charles E et al. (2017) RESA identifies mRNA-regulatory sequences at high resolution. Nat Methods 14:201-207
Brown, Samara; Pineda, Cristiana M; Xin, Tianchi et al. (2017) Correction of aberrant growth preserves tissue homeostasis. Nature 548:334-337
Burclaff, Joseph; Mills, Jason C (2017) Cell biology: Healthy skin rejects cancer. Nature 548:289-290
Xin, Daisy; Christopher, Kasey J; Zeng, Lewie et al. (2017) IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture. Development 144:1544-1553
Tao, T; Sondalle, S B; Shi, H et al. (2017) The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. Oncogene 36:3852-3867
Paolini, Nahuel A; Attwood, Martin; Sondalle, Samuel B et al. (2017) A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism. Am J Hum Genet 100:506-522
Sondalle, S B; Baserga, S J; Yelick, P C (2016) The Contributions of the Ribosome Biogenesis Protein Utp5/WDR43 to Craniofacial Development. J Dent Res 95:1214-20
Yartseva, Valeria; Giraldez, Antonio J (2015) The Maternal-to-Zygotic Transition During Vertebrate Development: A Model for Reprogramming. Curr Top Dev Biol 113:191-232
Griffin, John N; Sondalle, Samuel B; Del Viso, Florencia et al. (2015) The ribosome biogenesis factor Nol11 is required for optimal rDNA transcription and craniofacial development in Xenopus. PLoS Genet 11:e1005018

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