The goal of the UCLA Training Program in Neuroendocrinology, Sex Differences, and Reproduction is to educate pre- and postdoctoral scholars in research, to prepare them for careers in scientific research and/or teaching. The Training Program is enhanced by the active participation of faculty members from diverse fields: genetics, molecular and cell biology, endocrinology, physiology, and behavioral science. The training faculty, members of the Laboratory of Neuroendocrinology (LNE), a research unit of the Brain Research Institute, are members of 11 UCLA departments. All faculty members are primarily or exclusively involved in basic research, but several are also physicians and thus bring a clinical perspective to the research of the group. A dominant characteristic of the LNE is active collaboration and interaction among the 12 independent research laboratories, at both the faculty and trainee levels, which considerably enriches the educational milieu for trainees. Trainees have free access to laboratories of all LNE faculty. This proposal requests funds to support 6 predoctoral and 3 postdoctoral scholars per year. Predoctoral students will be appointed for a period up to 4 years, and postdoctoral trainees for 2 years. Pre-doctoral trainees must be admitted to one of five Ph.D. programs Postdoctoral candidates apply directly to research mentors. The Training Program provides for weekly brown bag seminars, didactic graduate courses and seminars, the Charles Sawyer Distinguished Lectureship, instruction in ethical conduct of science and career skills, and for intensive mentoring of minority undergraduate students. The target fields of research include study of how the brain and gonads communicate with each other to control reproduction;how hormones affect the ability of the brain to respond to disease;and how hormones and sex chromosome genes produce sex differences in the brain and other organs that influences their basic function and susceptibility to disease. The training program will help educate the next generation of scientists who will perform research to provide information that influences how physicians conceptualize and treat specific diseases, especially those related to reproduction, and how they treat diseases differently in men and women.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007228-30
Application #
7825248
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1981-07-01
Project End
2011-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
30
Fiscal Year
2010
Total Cost
$280,034
Indirect Cost
Name
University of California Los Angeles
Department
Physiology
Type
Schools of Arts and Sciences
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Golden, Lisa C; Voskuhl, Rhonda (2017) The importance of studying sex differences in disease: The example of multiple sclerosis. J Neurosci Res 95:633-643
Mittelman-Smith, Melinda A; Rudolph, Lauren M; Mohr, Margaret A et al. (2017) Rodent Models of Non-classical Progesterone Action Regulating Ovulation. Front Endocrinol (Lausanne) 8:165
Fraley, E R; Burkett, Z D; Day, N F et al. (2016) Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns. Sci Rep 6:25807
Rudolph, Lauren M; Cornil, Charlotte A; Mittelman-Smith, Melinda A et al. (2016) Actions of Steroids: New Neurotransmitters. J Neurosci 36:11449-11458
Arnold, Arthur P; Reue, Karen; Eghbali, Mansoureh et al. (2016) The importance of having two X chromosomes. Philos Trans R Soc Lond B Biol Sci 371:20150113
Fuxjager, Matthew J; Lee, Jae-Hyung; Chan, Tak-Ming et al. (2016) Research Resource: Hormones, Genes, and Athleticism: Effect of Androgens on the Avian Muscular Transcriptome. Mol Endocrinol 30:254-71
Kuljis, Dika A; Gad, Laura; Loh, Dawn H et al. (2016) Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington's Disease. PLoS One 11:e0147583
Fuxjager, Matthew J; Schuppe, Eric R; Hoang, John et al. (2016) Expression of 5?- and 5?-reductase in spinal cord and muscle of birds with different courtship repertoires. Front Zool 13:25
Bramble, Matthew S; Goldstein, Ellen H; Lipson, Allen et al. (2016) A novel follicle-stimulating hormone receptor mutation causing primary ovarian failure: a fertility application of whole exome sequencing. Hum Reprod 31:905-14
Hui, Simon T; Parks, Brian W; Org, Elin et al. (2015) The genetic architecture of NAFLD among inbred strains of mice. Elife 4:e05607

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