This Training Program prepares physicians and scientists for investigative careers in reproductive biology. During its 25 year history, the program has trained 74 postdoctoral fellows and graduate students. The program is multifaceted and broadly based. Research training is provided by 25 members of the Center for Reproductive Sciences (CRS) who hold faculty positions in 12 departments and organized research units. The Faculty have a broad range of scientific expertise and activities in reproductive biology, including: germ cell development, meiosis, follicular maturation, regulation of endometrial and placental function, mechanisms of hormone action;molecular genetics, steroid biosynthesis and action, endometrial and placental function, endocrine regulation of normal and abnormal reproductive function, basic and clinical studies of PCOS. Technologies available include: human and mouse embryology, transgenic mice, embryonic stem cells, human genetics and genomics, microarrays and proteomics, mass spectrometric analysis of proteins and small molecules, in vitro fertilization, whole animal physiology, prospective clinical investigation. Following formal application to the CRS or to an appropriate graduate program, trainees are selected by an Admissions Committee. Graduate students pursue a course of study leading to the Ph.D. degree. Postdoctoral training will be offered to Ph.D. candidates in related disciplines, and to clinically trained M.D. scientists with prior specialty training. In addition to their research work, trainees take prescribed academic courses, seminars, journal clubs, conferences, and seminars on the responsible conduct of research. Trainees learn to design and execute basic research projects, analyze data and write manuscripts for prominent peer-reviewed journals. Trainees prepare and submit grant applications for extramural funding, preparing them for independent academic careers. Trainee academic development is assured by mentoring committees through individual development plans;success of trainees and the training program is tracked through yearly surveys of alumni. The strengths of the program include: 1.) the diverse skills and interests of the faculty, 2.) the interactiveness of the faculty, 3.) our substantial laboratory resources, and 4.) the outstanding environment for research in reproduction, development, endocrinology, cell biology, genetics and related areas at UCSF.

Public Health Relevance

Human reproduction affects all generations, yet many questions remain concerning both the basic biology and clinical issues in women's health. This program integrates faculty in basic science and clinical investigation and seeks to train investigators to study both basic and clinical human reproductive biology to improve the health of women and children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007263-29
Application #
8266267
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1983-07-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
29
Fiscal Year
2012
Total Cost
$167,578
Indirect Cost
$12,280
Name
University of California San Francisco
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Feuer, Sky; Rinaudo, Paolo (2016) From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies. Healthcare (Basel) 4:
Cakmak, Hakan; Franciosi, Federica; Zamah, A Musa et al. (2016) Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells. Proc Natl Acad Sci U S A 113:2424-9
Bayless, Daniel W; Shah, Nirao M (2016) Genetic dissection of neural circuits underlying sexually dimorphic social behaviours. Philos Trans R Soc Lond B Biol Sci 371:20150109
Parchem, Ronald J; Moore, Nicole; Fish, Jennifer L et al. (2015) miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep 12:760-73
Faire, Mehlika; Skillern, Amanda; Arora, Ripla et al. (2015) Follicle dynamics and global organization in the intact mouse ovary. Dev Biol 403:69-79
Parchem, Ronald J; Ye, Julia; Judson, Robert L et al. (2014) Two miRNA clusters reveal alternative paths in late-stage reprogramming. Cell Stem Cell 14:617-31
Chen, Joseph C; Erikson, David W; Piltonen, Terhi T et al. (2013) Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production. Fertil Steril 100:1132-43
Cakmak, Hakan; Fujimoto, Victor Y; Zamah, A Musa et al. (2012) Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle. J Assist Reprod Genet 29:1203-5
Lamb, Julie D; Zamah, A Musa; Shen, Shehua et al. (2010) Follicular fluid steroid hormone levels are associated with fertilization outcome after intracytoplasmic sperm injection. Fertil Steril 94:952-7
Babiarz, Joshua E; Ruby, J Graham; Wang, Yangming et al. (2008) Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev 22:2773-85

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