The objective of this proposal is to train predoctoral students in Developmental Biology. Thirty-five faculty propose continuation of a broad, interdisciplinarytraining program. These faculty use molecular, cellbiological and genetic approaches to address fundamental problems in developmental biology. Participating faculty have appointments in a total of 14 basic science and clinical departments within the university. All have extremely active research programs. Productive interactions between laboratories and trainees are promoted by an annual retreat, symposium/journal club series, joint research meetings, shared supervision, and a variety of collaborations. The program is conducted within the broader context of the Program in Biological Sciences, a consortium of eight UCSF graduate programs with more than 100 participatingfaculty. It attracts students of exceptionally high caliber. The features of our training program that are especially attractive to prospective students are the following: (1) a wide choice of laboratories for thesis research, (2) a laboratory rotation system, (3) an excellent set of courses, (4) a tutorial in how to present a seminar, (5) a highly cooperative spirit, and (6) an awareness that graduate training is important to the faculty at UCSF. We strive to facilitate the intellectual growth and scientific skills of each trainee so that each graduates as an independentscientist who will be able to contribute to the field for many decades to come.
Training the next generation of developmental biologists is essential for gaining an understanding of the fundamental mechanisms of embryonic development, which is one of the most expeditious routes to discovering therapies for many human diseases.
|Buckley, Clare E; Moore, Rachel E; Reade, Anna et al. (2016) Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo. Dev Cell 36:117-26|
|Dinsmore, Colin; Reiter, Jeremy F (2016) Endothelial primary cilia inhibit atherosclerosis. EMBO Rep 17:156-66|
|Faire, Mehlika; Skillern, Amanda; Arora, Ripla et al. (2015) Follicle dynamics and global organization in the intact mouse ovary. Dev Biol 403:69-79|
|Hesse, Robert G; Kouklis, Gayle K; Ahituv, Nadav et al. (2015) The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration. Elife 4:|
|Yu, Dan; Baird, Michelle A; Allen, John R et al. (2015) A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods 12:763-5|
|White, Mark P; Theodoris, Christina V; Liu, Lei et al. (2015) NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. J Mol Cell Cardiol 84:13-23|
|Xu, Xiaoti; Wilschut, Karlijn J; Kouklis, Gayle et al. (2015) Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles. Stem Cell Reports 5:419-34|
|Yee, Laura E; Garcia-Gonzalo, Francesc R; Bowie, Rachel V et al. (2015) Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. PLoS Genet 11:e1005627|
|Theodoris, Christina V; Li, Molong; White, Mark P et al. (2015) Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency. Cell 160:1072-86|
|Shai, Anny; Dankort, David; Juan, Joseph et al. (2015) TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. Cancer Res 75:3167-80|
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