The objective of this proposal is to train predoctoral students in Developmental Biology. Thirty-five faculty propose continuation of a broad, interdisciplinarytraining program. These faculty use molecular, cellbiological and genetic approaches to address fundamental problems in developmental biology. Participating faculty have appointments in a total of 14 basic science and clinical departments within the university. All have extremely active research programs. Productive interactions between laboratories and trainees are promoted by an annual retreat, symposium/journal club series, joint research meetings, shared supervision, and a variety of collaborations. The program is conducted within the broader context of the Program in Biological Sciences, a consortium of eight UCSF graduate programs with more than 100 participatingfaculty. It attracts students of exceptionally high caliber. The features of our training program that are especially attractive to prospective students are the following: (1) a wide choice of laboratories for thesis research, (2) a laboratory rotation system, (3) an excellent set of courses, (4) a tutorial in how to present a seminar, (5) a highly cooperative spirit, and (6) an awareness that graduate training is important to the faculty at UCSF. We strive to facilitate the intellectual growth and scientific skills of each trainee so that each graduates as an independentscientist who will be able to contribute to the field for many decades to come.

Public Health Relevance

Training the next generation of developmental biologists is essential for gaining an understanding of the fundamental mechanisms of embryonic development, which is one of the most expeditious routes to discovering therapies for many human diseases.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007470-20
Application #
8469062
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Mukhopadhyay, Mahua
Project Start
1994-07-01
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
20
Fiscal Year
2013
Total Cost
$283,549
Indirect Cost
$17,108
Name
University of California San Francisco
Department
Orthopedics
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Kimmel, Jacob C; Chang, Amy Y; Brack, Andrew S et al. (2018) Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance. PLoS Comput Biol 14:e1005927
Yang, Xiao Yong; Stanley, Robert E; Ross, Adam P et al. (2018) Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation. Cereb Cortex :
Andersen, Rebecca E; Lim, Daniel A (2018) Forging our understanding of lncRNAs in the brain. Cell Tissue Res 371:55-71
Pla, Ramon; Stanco, Amelia; Howard, MacKenzie A et al. (2018) Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis. Cereb Cortex 28:3797-3815
Woronowicz, Katherine C; Gline, Stephanie E; Herfat, Safa T et al. (2018) FGF and TGF? signaling link form and function during jaw development and evolution. Dev Biol :
Freimer, Jacob W; Krishnakumar, Raga; Cook, Matthew S et al. (2018) Expression of Alternative Ago2 Isoform Associated with Loss of microRNA-Driven Translational Repression in Mouse Oocytes. Curr Biol 28:296-302.e3
Smith, Lucas K; White 3rd, Charles W; Villeda, Saul A (2018) The systemic environment: at the interface of aging and adult neurogenesis. Cell Tissue Res 371:105-113
Altshuler-Keylin, Svetlana; Kajimura, Shingo (2017) Mitochondrial homeostasis in adipose tissue remodeling. Sci Signal 10:
Susman, Michael W; Karuna, Edith P; Kunz, Ryan C et al. (2017) Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Elife 6:
Hérault, Aurélie; Binnewies, Mikhail; Leong, Stephanie et al. (2017) Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. Nature 544:53-58

Showing the most recent 10 out of 80 publications