We seek to renew support for training of up to 10 predoctoral students per year in the Developmental and Stem Cell Biology (DSCB) Graduate Program at UCSF. The DSCB program builds off of a foundation of cell biology, biochemistry and genetics to instill deep understanding of development and developmental disorders. As the field of developmental biology is rapidly advancing, we provide our students a dynamic, interdisciplinary education that incorporates the most recent conceptual and experimental advances. Our students acquire the concepts and skills to make groundbreaking contributions to developmental biology, as evidenced by their pioneering discoveries and successful scientific careers. DSCB is a degree-granting, cross-campus program governed by an Executive Committee and run by a Director and an Associate Director. 61 faculty members in 18 basic science and clinical departments participate in the program. The faculty are leaders in their respective fields, have active research laboratories, and provide extensive mentorship to DSCB students to maintain membership. New interactions among laboratories and trainees are facilitated by an annual retreat, seminars, an annual student-run symposium, two weekly journal clubs, faculty research talks, joint research meetings, and shared student supervision. Previously (1994-2010), this grant supported students who studied developmental biology through two broader graduate programs. During the last funding period, the DSCB program instituted a wide range of improvements to make the training more dynamic and interdisciplinary. These changes culminated, in 2011, with the DSCB program conducting its own admissions and creating its own curriculum, allowing us to attract students from diverse backgrounds and of exceptionally high caliber who choose to join the DSCB program for its broad range of thriving thesis research laboratories and a faculty dedicated to excellence in graduate education. Other improvements that we have enacted include: (1) introducing an effective system of six-week laboratory rotations that accelerates selection of a thesis laboratory and helps reduce the years to degree;(2) completely overhauling the core developmental biology course and integrating it with revised courses in cell biology and genetics;(3) establishing literature-intensive, small group mini-courses;(4) expanding instruction on grant-writing, oral presentation, peer-review, ethics and the responsible conduct of research;(5) providing additional opportunities for teaching and leadership experience; (6) ensuring access to state-of-the-art equipment and facilities;and (7) expanding our cooperative, interactive faculty. The training grant supports students during their 1st and 2nd years of study. Student progress is monitored through classes, program requirements such as the qualifying exam, and regular thesis committee meetings. Students have been very successful at acquiring independent funding to cover subsequent years. Renewal of this training grant will support the intellectual growth of DSCB students, ensuring that each graduate is an independent scientist who helps lead the field of developmental biology for decades to come.

Public Health Relevance

The goal of predoctoral training in Developmental and Stem Cell Biology at UCSF is to provide a world-class education for the next generation of researchers in the field, equipping them to make fundamental discoveries about mechanisms underlying normal and abnormal human development. Trainees go on to have highly successful careers in academia and the biotechnology industry. Human health and society-at-large will benefit directly as our training program produces creative, highly trained scientists dedicated to creating transformative molecular and cell-based therapies for birth defects, injuries and currently intractable childhood diseases.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DRG-D (90))
Program Officer
Mukhopadhyay, Mahua
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Schools of Medicine
San Francisco
United States
Zip Code
Buckley, Clare E; Moore, Rachel E; Reade, Anna et al. (2016) Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo. Dev Cell 36:117-26
Dinsmore, Colin; Reiter, Jeremy F (2016) Endothelial primary cilia inhibit atherosclerosis. EMBO Rep 17:156-66
Faire, Mehlika; Skillern, Amanda; Arora, Ripla et al. (2015) Follicle dynamics and global organization in the intact mouse ovary. Dev Biol 403:69-79
Hesse, Robert G; Kouklis, Gayle K; Ahituv, Nadav et al. (2015) The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration. Elife 4:
Yu, Dan; Baird, Michelle A; Allen, John R et al. (2015) A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods 12:763-5
White, Mark P; Theodoris, Christina V; Liu, Lei et al. (2015) NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. J Mol Cell Cardiol 84:13-23
Xu, Xiaoti; Wilschut, Karlijn J; Kouklis, Gayle et al. (2015) Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles. Stem Cell Reports 5:419-34
Yee, Laura E; Garcia-Gonzalo, Francesc R; Bowie, Rachel V et al. (2015) Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. PLoS Genet 11:e1005627
Theodoris, Christina V; Li, Molong; White, Mark P et al. (2015) Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency. Cell 160:1072-86
Shai, Anny; Dankort, David; Juan, Joseph et al. (2015) TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. Cancer Res 75:3167-80

Showing the most recent 10 out of 43 publications